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Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats
Wang, Wenjuan1; Wang, Zhiyuan1; Bai, Wenpei2; Zhang, Hui2; Ma, Xiaoyan2; Yang, Mukun2; Wang, Ke1; Zhu, Sainan3; Jia, Jing4; Qin, Lihua1
关键词Preoptic Area Of Hypothalamus (Poah) Temperature Stimuli C-fos Ovariectomized Rats
刊名ACTA HISTOCHEMICA
2014
DOI10.1016/j.acthis.2014.07.010
116期:8页:1259-1269
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]ADIPOSE-TISSUE ; COLD-EXPOSURE ; C-FOS ; SLEEP ; THERMOREGULATION ; EXPRESSION ; BRAIN ; MICE
英文摘要

The purpose of this study was to investigate the difference in neuronal activity in the preoptic area of the hypothalamus (POAH) under low estrogen condition induced by ovariectomy. One hundred and twenty sham-operated (SHAM) and ovariectomized (OVX) rats were placed in different temperatures for 2 h. Twelve rats from each group were stimulated by 4 degrees C, 10 degrees C, 25 degrees C, 33 degrees C and 38 degrees C, respectively. c-Fos expression in the POAH was detected by immunohistochemistry. Following exposure to warm and cold stimuli, there were markedly lower c-Fos-positive cell densities in the OVX group compared with the SHAM group in the median preoptic nucleus (MnPO) at 4 degrees C, 10 degrees C, 33 degrees C and 38 degrees C, in the medial preoptic area (MPA) at 25 degrees C and 38 degrees C, in the ventromedial preoptic nucleus (VMPO) at 4 degrees C, 10 degrees C and 38 degrees C and in the ventrolateral preoptic nucleus (VLPO) at 4 degrees C and 38 degrees C. Both temperature and surgery had an impact on c-Fos expression by two-way ANOVA method except in the lateral preoptic area (LPO). c-Fos expression differed within different nuclei of the two groups in the same and different temperature stimuli. This indicated that the temperature-sensitive nuclei in the POAH exhibited lower and different activities during temperature stimuli following ovariectomy, which possibly resulted in abnormal thermoregulation and menopausal symptoms. (C) 2014 Elsevier GmbH. All rights reserved.

语种英语
WOS记录号WOS:000347362000009
项目编号81070462 ; 7113168
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50821
专题北京大学第一临床医学院
北京大学基础医学院
北京大学第一临床医学院_医学统计室
作者单位1.Peking Univ, Hosp 1, Stat Off, Beijing 100871, Peoples R China
2.Gen Hosp Armed Police, Dept Stomatol, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat & Embryol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Wenjuan,Wang, Zhiyuan,Bai, Wenpei,et al. Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats[J]. ACTA HISTOCHEMICA,2014,116(8):1259-1269.
APA Wang, Wenjuan.,Wang, Zhiyuan.,Bai, Wenpei.,Zhang, Hui.,Ma, Xiaoyan.,...&Qin, Lihua.(2014).Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats.ACTA HISTOCHEMICA,116(8),1259-1269.
MLA Wang, Wenjuan,et al."Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats".ACTA HISTOCHEMICA 116.8(2014):1259-1269.
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