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学科主题: 临床医学
题名:
Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats
作者: Wang, Wenjuan1; Wang, Zhiyuan1; Bai, Wenpei2; Zhang, Hui2; Ma, Xiaoyan2; Yang, Mukun2; Wang, Ke1; Zhu, Sainan3; Jia, Jing4; Qin, Lihua1
关键词: Preoptic area of hypothalamus (POAH) ; Temperature stimuli ; c-Fos ; Ovariectomized rats
刊名: ACTA HISTOCHEMICA
发表日期: 2014
DOI: 10.1016/j.acthis.2014.07.010
卷: 116, 期:8, 页:1259-1269
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: ADIPOSE-TISSUE ; COLD-EXPOSURE ; C-FOS ; SLEEP ; THERMOREGULATION ; EXPRESSION ; BRAIN ; MICE
英文摘要:

The purpose of this study was to investigate the difference in neuronal activity in the preoptic area of the hypothalamus (POAH) under low estrogen condition induced by ovariectomy. One hundred and twenty sham-operated (SHAM) and ovariectomized (OVX) rats were placed in different temperatures for 2 h. Twelve rats from each group were stimulated by 4 degrees C, 10 degrees C, 25 degrees C, 33 degrees C and 38 degrees C, respectively. c-Fos expression in the POAH was detected by immunohistochemistry. Following exposure to warm and cold stimuli, there were markedly lower c-Fos-positive cell densities in the OVX group compared with the SHAM group in the median preoptic nucleus (MnPO) at 4 degrees C, 10 degrees C, 33 degrees C and 38 degrees C, in the medial preoptic area (MPA) at 25 degrees C and 38 degrees C, in the ventromedial preoptic nucleus (VMPO) at 4 degrees C, 10 degrees C and 38 degrees C and in the ventrolateral preoptic nucleus (VLPO) at 4 degrees C and 38 degrees C. Both temperature and surgery had an impact on c-Fos expression by two-way ANOVA method except in the lateral preoptic area (LPO). c-Fos expression differed within different nuclei of the two groups in the same and different temperature stimuli. This indicated that the temperature-sensitive nuclei in the POAH exhibited lower and different activities during temperature stimuli following ovariectomy, which possibly resulted in abnormal thermoregulation and menopausal symptoms. (C) 2014 Elsevier GmbH. All rights reserved.

语种: 英语
所属项目编号: 81070462 ; 7113168
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing
WOS记录号: WOS:000347362000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50821
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Stat Off, Beijing 100871, Peoples R China
2.Gen Hosp Armed Police, Dept Stomatol, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat & Embryol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Wenjuan,Wang, Zhiyuan,Bai, Wenpei,et al. Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats[J]. ACTA HISTOCHEMICA,2014,116(8):1259-1269.
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