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学科主题临床医学
Oestradiol ameliorates monocrotaline pulmonary hypertension via NO, prostacyclin and endothelin-1 pathways
Yuan, Ping1; Wu, Wen-Hui1; Gao, Lan2; Zheng, Ze-Qi3; Liu, Dong1; Mei, Han-Ying3; Zhang, Zhuo-Li2; Jing, Zhi-Cheng1,4
关键词17 Beta-oestradiol Metabolic Enzymes Oestrogen Receptors Pulmonary Hypertension
刊名EUROPEAN RESPIRATORY JOURNAL
2013-05-01
DOI10.1183/09031936.00044112
41期:5页:1116-1125
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Respiratory System
研究领域[WOS]Respiratory System
关键词[WOS]ARTERIAL-HYPERTENSION ; NITRIC-OXIDE ; REPLACEMENT THERAPY ; ESTROGEN ; DISEASE ; RATS ; ENOS ; EXPRESSION ; MANAGEMENT ; INHIBITOR
英文摘要

Pulmonary hypertension continues to be a serious clinical problem with high mortality. As oestrogen is a potential vasodilator of the pulmonary circulation, this study examined the mechanisms by which 17 beta-oestradiol improves monocrotaline (MCT)-induced pulmonary hypertension.

Female Sprague-Dawley rats underwent bilateral ovariectomy or sham operations. The rats received MCI (50 mg.kg(-1)) and were treated with 17 beta-oestradiol (1 mg.kg(-1) per day) for either 5 weeks or only from week 4 to week 5. Plasma 17 beta-oestradiol concentrations were decreased in sham-operated, MCT-treated rats when compared with sham-operated rats (17.7 +/- 4.7 versus 50.3 +/- 15.4 pg.mL(-1); p=0.029). The 17 beta-oestradiol anabolic enzyme cytochrome P450 (CYP)-19 was decreased by MCT treatment, while the catabolic enzymes CYP-1A1 and -1B1 were increased. Ovariectomised and MCI-treated rats had more severe pulmonary hypertension. 17 beta-oestradiol suppressed pulmonary arterial smooth muscle cell proliferation and macrophage infiltration, and enhanced apoptosis by increasing nitric oxide (NO) and prostacyclin (prostaglandin (PG)I-2) levels and reducing endothelin (ET)-1 levels. Phosphoinositide-3-kinase (PI3K) and Akt phosphorylations were markedly increased, but were inhibited by 17 beta-oestradiol treatment in rats with pulmonary hypertension.

Oestrogen deficiency may aggravate development of pulmonary hypertension. 17 beta-oestradiol improved pulmonary hypertension via activation of the PI3K/Akt pathway to regulate NO, PGI(2) and ET-1 expression.

语种英语
WOS记录号WOS:000318750300020
项目编号09ZZ35 ; 81170300 ; 10SG25 ; NCET-10-0630 ; SHDC12010102
资助机构Shanghai Municipal Education Commission ; National Natural Science Foundation of China ; Programme for Shanghai Outstanding Academic Leader ; "Dawn" Programme of the Shanghai Education Commission ; Programme for New Century Excellent Talents in University ; New and Frontier Project of Shanghai Shenkang Hospital Development Centre
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50824
专题北京大学第一临床医学院_风湿免疫科
作者单位1.Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Cardiopulm Circulat, Shanghai, Peoples R China
2.Beijing Univ, Hlth Sci Ctr, Beijing Univ Hosp 1, Dept Rheumatol, Beijing 100871, Peoples R China
3.Nanchang Univ, Affiliated Hosp 1, Dept Cardiol, Nanchang, Jiangxi, Peoples R China
4.Fu Wai Hosp, PUMC&CAMS, Dept Cardiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Yuan, Ping,Wu, Wen-Hui,Gao, Lan,et al. Oestradiol ameliorates monocrotaline pulmonary hypertension via NO, prostacyclin and endothelin-1 pathways[J]. EUROPEAN RESPIRATORY JOURNAL,2013,41(5):1116-1125.
APA Yuan, Ping.,Wu, Wen-Hui.,Gao, Lan.,Zheng, Ze-Qi.,Liu, Dong.,...&Jing, Zhi-Cheng.(2013).Oestradiol ameliorates monocrotaline pulmonary hypertension via NO, prostacyclin and endothelin-1 pathways.EUROPEAN RESPIRATORY JOURNAL,41(5),1116-1125.
MLA Yuan, Ping,et al."Oestradiol ameliorates monocrotaline pulmonary hypertension via NO, prostacyclin and endothelin-1 pathways".EUROPEAN RESPIRATORY JOURNAL 41.5(2013):1116-1125.
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