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Neonatal MK-801 treatment differentially alters the effect of adolescent or adult MK-801 challenge on locomotion and PPI in male and female rats
Zhao, Ying-Ying; Li, Ji-Tao; Wang, Xiao-Dong; Li, You-Hong; Huang, Run-Hu; Su, Yun-Ai; Si, Tian-Mei
关键词Nmda Receptor Mk-801 Locomotor Activity Ppi Schizophrenia
刊名JOURNAL OF PSYCHOPHARMACOLOGY
2013-09-01
DOI10.1177/0269881113497613
27期:9页:845-853
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
资助者Natural Science Foundation of China ; Natural Science Foundation of China
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]PREPULSE INHIBITION ; RISK-FACTORS ; EARLY-ONSET ; SCHIZOPHRENIA ; MODEL ; PSYCHOSIS ; PATHOPHYSIOLOGY ; SENSITIZATION ; DYSFUNCTION ; DISRUPTION
英文摘要

Schizophrenia is a neurodevelopmental disorder and is typically triggered by subsequent insults in life. The N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) induces locomotor hyperactivity and prepulse inhibition (PPI) deficits, which can mimic the schizophrenia phenotype. In this experiment, we assessed whether neonatal exposure to MK-801 (postnatal days 5-14) could induce sensitization to both hyperactivity and PPI deficit caused by later-life acute MK-801 treatment during adolescence or adulthood. Our results showed that the hyperactivity induced by an acute MK-801 challenge was enhanced in male and female rats after neonatal MK-801 treatment. Notably, in the PPI test, adult female rats neonatally exposed to MK-801 exhibited a significantly greater reduction in PPI in response to acute MK-801 administration, whereas male rats receiving neonatal MK-801 treatment expressed attenuated PPI disruption in adulthood. Our data indicate that a combination of neonatal and later-life NMDA receptor blockades could induce sensitization in the locomotor activity of both sexes in adolescence and adulthood. In addition, a sex difference was observed in the effects of this treatment regime on PPI.

语种英语
所属项目编号81171284
资助者Natural Science Foundation of China ; Natural Science Foundation of China
WOS记录号WOS:000323644300010
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50826
专题北京大学精神卫生研究所
作者单位Peking Univ, Key Lab Mental Hlth, Inst Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
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Zhao, Ying-Ying,Li, Ji-Tao,Wang, Xiao-Dong,et al. Neonatal MK-801 treatment differentially alters the effect of adolescent or adult MK-801 challenge on locomotion and PPI in male and female rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2013,27(9):845-853.
APA Zhao, Ying-Ying.,Li, Ji-Tao.,Wang, Xiao-Dong.,Li, You-Hong.,Huang, Run-Hu.,...&Si, Tian-Mei.(2013).Neonatal MK-801 treatment differentially alters the effect of adolescent or adult MK-801 challenge on locomotion and PPI in male and female rats.JOURNAL OF PSYCHOPHARMACOLOGY,27(9),845-853.
MLA Zhao, Ying-Ying,et al."Neonatal MK-801 treatment differentially alters the effect of adolescent or adult MK-801 challenge on locomotion and PPI in male and female rats".JOURNAL OF PSYCHOPHARMACOLOGY 27.9(2013):845-853.
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