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The changing spectrum of primary glomerular diseases within 15 years: A survey of 3331 patients in a single Chinese centre
Zhou, Fu-de; Zhao, Ming-hui; Zou, Wan-zhong; Liu, Gang; Wang, Haiyan
关键词Focal Segmental Glomerulosclerosis Iga Nephropathy Minimal Change Disease Mesangioproliferative Glomerulonephritis Primary Glomerulonephritis
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2009-03-01
DOI10.1093/ndt/gfn554
24期:3页:870-876
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]FOCAL SEGMENTAL GLOMERULOSCLEROSIS ; RENAL-DISEASES ; PRIMARY GLOMERULONEPHRITIS ; EPIDEMIOLOGIC DATA ; REGISTRY ; ADULTS ; PREVALENCE ; FREQUENCY ; SINGAPORE ; BIOPSIES
英文摘要

Background. Primary glomerular disease (PGD) is the leading cause of end-stage renal disease (ESRD) in China. With the development of socioeconomic status of Chinese people in the last two decades, PGD in ESRD is intent to decrease. However, whether this affects the spectrum of PGD is not clear. The aim of the current study is to investigate the changing spectrum of PGD in China.

Methods. The records of 5398 consecutive native renal biopsies performed in adults (>= 14 years of age) in our centre between 1993 and 2007 were retrospectively analysed. The criteria for renal biopsy and pathologic diagnosis were kept unchanged. The patients were grouped according to a 5-year interval, 1993-97 (period 1), 1998-2002 (period 2) and 2003-07 (period 3). Then they were divided into four groups according to age for stratified analysis: 14-24 years, 25-44 years, 45-59 years and the elderly (>= 60 years).

Results. Three thousand, three hundred and thirty-one patients were diagnosed with PGD. PGD remained the most common renal disease, accounting for 65.9%, 57.7% and 63.2% in period 1, 2 and 3, respectively, without any significant difference. The proportion of elder patients increased significantly from 0% in 1993 to 9.1% in 2007 (P < 0.001). Within 1993-97, the leading PGD was IgA nephropathy (50.7%), followed by non-IgA MsPGN (19.9%), membranous nephropathy (MN) (13.3%) and minimal change disease (MCD) (6.3%), while within 2003-07, the most common PGD was still IgAN (58.2%), but followed by MN (14.3%), MCD (13.4%) and non-IgA MsPGN (7.0%). The age-adjusted frequency of IgAN and MCD increased significantly from period 1 to period 3 (P < 0.01 and P < 0.001, respectively), while that of non-IgA MsPGN, EnPGN and MPGN decreased significantly (P < 0.001, P < 0.01 and P < 0.05, respectively). There was no significant change in the age-adjusted frequency of FSGS, MN and CreGN during the study period. However, when patients were stratified by age, a sixfold increase in frequency of FSGS was identified in the 14- to 24-year group (P < 0.01).

Conclusions. The spectrum of primary glomerulonephritis has changed within the last 15 years. The relative frequency of non-IgA MsPGN, EnPGN and MPGN decreased significantly, while that of MCD and IgA nephropathy increased significantly. The relative frequency of FSGS increased significantly in younger patients.

语种英语
WOS记录号WOS:000263605000029
项目编号985-2-033-39
资助机构Peking University Fund for Prevention and Treatment of Chronic Kidney Disease
引用统计
被引频次:84[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50832
专题北京大学第一临床医学院_肾脏内科
北京大学基础医学院
作者单位Peking Univ, Minist Hlth China, Inst Nephrol, Div Renal,Key Lab Renal Dis,Hosp 1,Dept Med, Beijing 100034, Peoples R China
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Zhou, Fu-de,Zhao, Ming-hui,Zou, Wan-zhong,et al. The changing spectrum of primary glomerular diseases within 15 years: A survey of 3331 patients in a single Chinese centre[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2009,24(3):870-876.
APA Zhou, Fu-de,Zhao, Ming-hui,Zou, Wan-zhong,Liu, Gang,&Wang, Haiyan.(2009).The changing spectrum of primary glomerular diseases within 15 years: A survey of 3331 patients in a single Chinese centre.NEPHROLOGY DIALYSIS TRANSPLANTATION,24(3),870-876.
MLA Zhou, Fu-de,et al."The changing spectrum of primary glomerular diseases within 15 years: A survey of 3331 patients in a single Chinese centre".NEPHROLOGY DIALYSIS TRANSPLANTATION 24.3(2009):870-876.
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