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学科主题: 基础医学
题名:
High Manganese, A Risk for Alzheimer′s Disease: High Manganese Induces Amyloid-beta Related Cognitive Impairment
作者: Tong, Yawei1,2,3; Yang, Huan1,2,3; Tian, Xiaosheng1,2,3; Wang, Hecheng1,2,3; Zhou, Ting1,2,3; Zhang, Shouzi4; Yu, Jia1,2,3,4; Zhang, Tao1,2,3; Fan, Dongshen5; Guo, Xiangyang6; Tabira, Takeshi8; Kong, Fanjun7; Chen, Zheng4; Xiao, Weizhong5; Chui, Dehua1,2,3
关键词: High manganese (Mn) ; cognitive impairment ; amyloid-beta (Abeta) ; Alzheimer&prime ; s disease (AD) ; A beta degradation
刊名: JOURNAL OF ALZHEIMERS DISEASE
发表日期: 2014
DOI: 10.3233/JAD-140534
卷: 42, 期:3, 页:865-878
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CEREBROSPINAL-FLUID ; RAT-BRAIN ; INDUCED NEUROTOXICITY ; GLUTAMINE-SYNTHETASE ; PRECURSOR PROTEIN ; OXIDATIVE STRESS ; PLASMA ; CELLS ; NEPRILYSIN ; SPECIATION
英文摘要:

Excess manganese (Mn) in brain can be neurotoxic, implicated in several neurodegenerative disorders such as sporadic Alzheimer′s disease (AD). However, little is known about the altered metal environment including elevated Mn in the progressive cognitive impairment of AD. Indeed, whether high Mn is associated with AD risk remains elusive. In the study, we recruited 40 Chinese elders with different cognitive statuses and investigated concentrations of Mn in whole blood and plasma amyloid-beta (A beta) peptides. Surprisingly, there were significant correlations of Mn with Mini- Mental State Examination score and Clinical Dementia Rating Scale score. In addition, plasma A beta peptides increased with elevated Mn. Further studies both in vitro and in vivo demonstrated dose- related neurotoxicity and increase of A beta by Mn treatment, which was probably caused by disrupted A beta degradation. These data suggested that high Mn may be involved in the progress of AD as an essential pathogenic factor.

语种: 英语
所属项目编号: 2012CB911000 ; 2012CB911004 ; 81171015 ; 81211140047
项目资助者: National High Technology Research and Development Program of China (973 Program) ; National Natural Science Foundation of China (NSFC) ; NSFC-JSPS
WOS记录号: WOS:000342237000015
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50835
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Dept Neurobiol,Key Lab Neurosci, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Beijing 100191, Peoples R China
4.Beijing Geriatr Hosp, Beijing, Peoples R China
5.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China
6.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
7.Affiliated Rehabil Hosp, Natl Res Ctr Rehabil Tech Aids, Beijing, Peoples R China
8.Juntendo Univ, Grad Sch Med, Dept Neurol, Bunkyo Ku, Tokyo, Japan

Recommended Citation:
Tong, Yawei,Yang, Huan,Tian, Xiaosheng,et al. High Manganese, A Risk for Alzheimer′s Disease: High Manganese Induces Amyloid-beta Related Cognitive Impairment[J]. JOURNAL OF ALZHEIMERS DISEASE,2014,42(3):865-878.
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