北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 放射科  > 期刊论文
学科主题: 临床医学
题名:
Quantitative T2 mapping evaluation for articular cartilage lesions in a rabbit model of anterior cruciate ligament transection osteoarthritis
作者: Wei Zheng-mao; Du Xiang-ke; Huo Tian-long; Li Xu-bin; Quan Guang-nan; Li Tian-ran; Cheng Jin; Zhang Wei-tao
关键词: magnetic resonance imaging ; osteoarthritis ; articular cartilage ; collagen type II
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-03-05
DOI: 10.3760/cma.j.issn.0366-6999.2012.05.021
卷: 125, 期:5, 页:843-850
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: SPATIAL VARIATION ; RELAXATION-TIME ; WATER-CONTENT ; KNEE ; MRI ; HISTOPATHOLOGY ; DEGENERATION
英文摘要:

Background Quantitative T2 mapping has been a widely used method for the evaluation of pathological cartilage properties, and the histological assessment system of osteoarthritis in the rabbit has been published recently. The aim of the study was to investigate the effectiveness of quantitative T2 mapping evaluation for articular cartilage lesions of a rabbit model of anterior cruciate ligament transection (ACLT) osteoarthritis.

Methods Twenty New Zealand White (NZW) rabbits were divided into ACLT surgical group and sham operated group equally. The anterior cruciate ligaments of the rabbits in ACLT group were transected, while the joints were closed intactly in sham operated group. Magnetic resonance (MR) examinations were performed on 3.0T MR unit at week 0, week 6, and week 12. T2 values were computed on GE ADW4.3 workstation. All rabbits were killed at week 13, and left knees were stained with Haematoxylin and Eosin. Semiquantitative histological grading was obtained according to the osteoarthritis cartilage histopathology assessment system. Computerized image analysis was performed to quantitate the immunostained collagen type II.

Results The average MR T2 value of whole left knee cartilage in ACLT surgical group ((29.05 +/- 12.01) ms) was significantly higher than that in sham operated group ((24.52 +/- 7.97) ms) (P=0.024) at week 6. The average T2 value increased to (32.18 +/- 12.79) ms in ACLT group at week 12, but remained near the baseline level ((27.66 +/- 8.08) ms) in the sham operated group (P=0.03). The cartilage lesion level of left knee in ACLT group was significantly increased at week 6 (P=0.005) and week 12 (P<0.001). T2 values had positive correlation with histological grading scores, but inverse correlation with optical densities (OD) of type II collagen.

Conclusion This study demonstrated the reliability and practicability of quantitative T2 mapping for the cartilage injury of rabbit ACLT osteoarthritis model. Chin Med J 2012;125(5):843-850

语种: 英语
所属项目编号: 81071203/H1808
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000301755200023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50839
Appears in Collections:北京大学第二临床医学院_放射科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China

Recommended Citation:
Wei Zheng-mao,Du Xiang-ke,Huo Tian-long,et al. Quantitative T2 mapping evaluation for articular cartilage lesions in a rabbit model of anterior cruciate ligament transection osteoarthritis[J]. CHINESE MEDICAL JOURNAL,2012,125(5):843-850.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wei Zheng-mao]'s Articles
[Du Xiang-ke]'s Articles
[Huo Tian-long]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wei Zheng-mao]‘s Articles
[Du Xiang-ke]‘s Articles
[Huo Tian-long]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace