IR@PKUHSC  > 北京大学第二临床医学院  > 放射科
学科主题临床医学
Quantitative T2 mapping evaluation for articular cartilage lesions in a rabbit model of anterior cruciate ligament transection osteoarthritis
Wei Zheng-mao; Du Xiang-ke; Huo Tian-long; Li Xu-bin; Quan Guang-nan; Li Tian-ran; Cheng Jin; Zhang Wei-tao
关键词Magnetic Resonance Imaging Osteoarthritis Articular Cartilage Collagen Type Ii
刊名CHINESE MEDICAL JOURNAL
2012-03-05
DOI10.3760/cma.j.issn.0366-6999.2012.05.021
125期:5页:843-850
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]SPATIAL VARIATION ; RELAXATION-TIME ; WATER-CONTENT ; KNEE ; MRI ; HISTOPATHOLOGY ; DEGENERATION
英文摘要

Background Quantitative T2 mapping has been a widely used method for the evaluation of pathological cartilage properties, and the histological assessment system of osteoarthritis in the rabbit has been published recently. The aim of the study was to investigate the effectiveness of quantitative T2 mapping evaluation for articular cartilage lesions of a rabbit model of anterior cruciate ligament transection (ACLT) osteoarthritis.

Methods Twenty New Zealand White (NZW) rabbits were divided into ACLT surgical group and sham operated group equally. The anterior cruciate ligaments of the rabbits in ACLT group were transected, while the joints were closed intactly in sham operated group. Magnetic resonance (MR) examinations were performed on 3.0T MR unit at week 0, week 6, and week 12. T2 values were computed on GE ADW4.3 workstation. All rabbits were killed at week 13, and left knees were stained with Haematoxylin and Eosin. Semiquantitative histological grading was obtained according to the osteoarthritis cartilage histopathology assessment system. Computerized image analysis was performed to quantitate the immunostained collagen type II.

Results The average MR T2 value of whole left knee cartilage in ACLT surgical group ((29.05 +/- 12.01) ms) was significantly higher than that in sham operated group ((24.52 +/- 7.97) ms) (P=0.024) at week 6. The average T2 value increased to (32.18 +/- 12.79) ms in ACLT group at week 12, but remained near the baseline level ((27.66 +/- 8.08) ms) in the sham operated group (P=0.03). The cartilage lesion level of left knee in ACLT group was significantly increased at week 6 (P=0.005) and week 12 (P<0.001). T2 values had positive correlation with histological grading scores, but inverse correlation with optical densities (OD) of type II collagen.

Conclusion This study demonstrated the reliability and practicability of quantitative T2 mapping for the cartilage injury of rabbit ACLT osteoarthritis model. Chin Med J 2012;125(5):843-850

语种英语
WOS记录号WOS:000301755200023
项目编号81071203/H1808
资助机构National Natural Science Foundation of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50839
专题北京大学第二临床医学院_放射科
作者单位Peking Univ Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wei Zheng-mao,Du Xiang-ke,Huo Tian-long,et al. Quantitative T2 mapping evaluation for articular cartilage lesions in a rabbit model of anterior cruciate ligament transection osteoarthritis[J]. CHINESE MEDICAL JOURNAL,2012,125(5):843-850.
APA Wei Zheng-mao.,Du Xiang-ke.,Huo Tian-long.,Li Xu-bin.,Quan Guang-nan.,...&Zhang Wei-tao.(2012).Quantitative T2 mapping evaluation for articular cartilage lesions in a rabbit model of anterior cruciate ligament transection osteoarthritis.CHINESE MEDICAL JOURNAL,125(5),843-850.
MLA Wei Zheng-mao,et al."Quantitative T2 mapping evaluation for articular cartilage lesions in a rabbit model of anterior cruciate ligament transection osteoarthritis".CHINESE MEDICAL JOURNAL 125.5(2012):843-850.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wei Zheng-mao]的文章
[Du Xiang-ke]的文章
[Huo Tian-long]的文章
百度学术
百度学术中相似的文章
[Wei Zheng-mao]的文章
[Du Xiang-ke]的文章
[Huo Tian-long]的文章
必应学术
必应学术中相似的文章
[Wei Zheng-mao]的文章
[Du Xiang-ke]的文章
[Huo Tian-long]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。