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学科主题: 临床医学
题名:
Identification of plate let-derived growth factor D in human chronic allograft nephropathy
作者: Liu, Gang2; Changsirikutchai, Siribha3; Hudkins, Kelly L.1; Banas, Miriam C.4; Kowatewska, Jolanta1; Yang, Xiangling1; Wietecha, Tomasz A.1; Votpone, John5; Gitbertson, Debra G.5; Atpers, Chartes E.1
关键词: PDGF-D ; transplantation ; allograft ; nephropathy
刊名: HUMAN PATHOLOGY
发表日期: 2008-03-01
卷: 39, 期:3, 页:393-402
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: MUSCLE-CELL-MIGRATION ; PDGF-D ; MONOCLONAL-ANTIBODY ; VASCULAR REJECTION ; FACTOR RECEPTOR ; EXPRESSION ; CLASSIFICATION ; INHIBITION ; CRITERIA ; KIDNEYS
英文摘要:

Chronic allograft nephropathy (CAN), a descriptive term denoting chronic scarring injury of the renal parenchyma and vasculature in allograft kidneys arising from various etiologies including chronic rejection, is the most common cause of late allograft failure, but mediators of this progressive injury largely remain unknown. We hypothesized that platelet-derived growth factor D (PDGF-D) and its specific receptor PDGF-R beta may be an important mediator in the pathogenesis of CAN and, hence, sought to identify its expression in this setting. Allograft nephrectomies demonstrating CAN, obtained from patients with irreversible transplant kidney failure (n = 15), were compared with renal tissues without prominent histopathological abnormalities (n = 18) and a series of renal allograft biopsies demonstrating acute vascular rejection (AVR) (n = 12). Antibodies to PDGF-D and PDGF-R,6 were used for immunohistochemistry. Double and triple immunohistochemistry was used to identify cell types expressing PDGF-D. PDGF-D was widely expressed in most neointimas in arteries exhibiting the chronic arteriopathy of CAN and only weakly expressed in a small proportion of sclerotic arteries in the other 2 groups. Double and triple immunolabeling demonstrated that the neointimal cells expressing PDGF-D were alpha-smooth muscle actin-expressing cells, but not infiltrating macrophages or endothelial cells. PDGF-R beta expression evaluated in serial sections was localized to the same sites where neointimal PDGF-D was expressed. PDGF-R beta was expressed in interstitial cells more abundantly in the CAN group compared with the normal and AVR groups, without demonstrable colocalization of PDGF-D. PDGF-D is present in the neointima of the arteriopathy of CAN, where it can engage PDGF-R beta to promote mesenchymal cell migration, proliferation, and neointima formation. PDGF-D may engage the PDGF-R beta to promote interstitial injury in chronic allograft injury, but its sources within the interstitium were unidentified. (c) 2008 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000253503500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50842
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Univ Washington, Dept Pathol, Med Ctr, Seattle, WA 98195 USA
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Zymogenet Inc, Seattle, WA 98102 USA
4.Srinakharinwirot Univ, Dept Med, Bangkok 10110, Thailand
5.Uniklinikum Regensberg, Klin & Poliklin Innere Med 2, D-93042 Regensburg, Germany

Recommended Citation:
Liu, Gang,Changsirikutchai, Siribha,Hudkins, Kelly L.,et al. Identification of plate let-derived growth factor D in human chronic allograft nephropathy[J]. HUMAN PATHOLOGY,2008,39(3):393-402.
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