|LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion|
|Wang, Hong1,2; Cao, Qingying1,2; Ge, Jun1,2; Liu, Chunmiao1; Ma, Yanhong1; Meng, Yuciu1; Wang, Yuxin1; Zhao, Xiaoli1; Liu, Ru1; Li, Caixia1; Wang, Yu3; Zhong, Julia4; Ju, Weina5; Jenkins, Edmund C.5; Brown, W. Ted5; Zhong, Nanbert1,2,3,5,6|
|关键词||Embryonic development first trimester long non-coding RNA (lncRNA) pathogenesis pathways spontaneous abortion|
|刊名||AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Immunology ; Reproductive Biology|
|研究领域[WOS]||Immunology ; Reproductive Biology|
|关键词[WOS]||LONG NONCODING RNA ; GENE-REGULATION ; ANTISENSE RNA ; MICRORNAS ; TRANSCRIPTION ; IDENTIFICATION ; MECHANISMS ; EVOLUTION ; ELEMENTS ; TARGETS|
Spontaneous abortion (SA) occurs before 20 gestational weeks. Approximately, half of recurrent SA has no identifiable cause. No report has yet been investigated the possible involvement of lncRNA in pregnancy loss.
Method of StudySixteen pairs of pregnancies with spontaneous abortions (SA) and induced abortions (IA) were studied. Embryonic sacs and decidua were collected for each pregnancy. A Human LncRNA Array was employed to profile genomewide lncRNAs, which were then validated by RT-PCR.
ResultsDifferentially expressed lncRNAs were identified. Biological pathways were categorized into six major groups: infection and inflammation, metabolism, signaling and transcriptional regulation, smooth muscle contraction, cell process, and coagulation.
ConclusionsInfection and inflammation pathways regulated by lncRNAs were determined as the predominant pathogenetic factors underlying the SA. Finding that antisense lncRNAs have been either up- or down-regulated suggests that they may have both cis- and trans-regulations.
|资助机构||Shijiazhuang Maternal and Obstetric Hospital ; March of Dimes Global Network for Maternal and Infant Health (MOD-GNMIH), Peking University Center of Medical Genetics (PUCMG) ; New York State Office for People with Developmental Disabilities (NYS OPWDD)|
|作者单位||1.Peking Univ, Ctr Med Genet, Beijing 100871, Peoples R China|
2.Shijiazhuang Obstet & Maternal Hlth Hosp, Shijiazhuang, Peoples R China
3.Hunter Coll High Sch, New York, NY USA
4.Chinese Alliance Translat Med Maternal & Children, Shijiazhuang, Peoples R China
5.Jiao Tong Univ, Shanghai Childrens Hosp, Shanghai 200030, Peoples R China
6.New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA
|Wang, Hong,Cao, Qingying,Ge, Jun,et al. LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion[J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY,2014,72(4):359-375.|
|APA||Wang, Hong.,Cao, Qingying.,Ge, Jun.,Liu, Chunmiao.,Ma, Yanhong.,...&Zhong, Nanbert.(2014).LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion.AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY,72(4),359-375.|
|MLA||Wang, Hong,et al."LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion".AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 72.4(2014):359-375.|
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