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学科主题: 基础医学
题名:
LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion
作者: Wang, Hong1,2; Cao, Qingying1,2; Ge, Jun1,2; Liu, Chunmiao1; Ma, Yanhong1; Meng, Yuciu1; Wang, Yuxin1; Zhao, Xiaoli1; Liu, Ru1; Li, Caixia1; Wang, Yu3; Zhong, Julia4; Ju, Weina5; Jenkins, Edmund C.5; Brown, W. Ted5; Zhong, Nanbert1,2,3,5,6
关键词: Embryonic development ; first trimester ; long non-coding RNA (lncRNA) ; pathogenesis ; pathways ; spontaneous abortion
刊名: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
发表日期: 2014-10-01
DOI: 10.1111/aji.12275
卷: 72, 期:4, 页:359-375
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Reproductive Biology
研究领域[WOS]: Immunology ; Reproductive Biology
关键词[WOS]: LONG NONCODING RNA ; GENE-REGULATION ; ANTISENSE RNA ; MICRORNAS ; TRANSCRIPTION ; IDENTIFICATION ; MECHANISMS ; EVOLUTION ; ELEMENTS ; TARGETS
英文摘要:

Problem

Spontaneous abortion (SA) occurs before 20 gestational weeks. Approximately, half of recurrent SA has no identifiable cause. No report has yet been investigated the possible involvement of lncRNA in pregnancy loss.

Method of StudySixteen pairs of pregnancies with spontaneous abortions (SA) and induced abortions (IA) were studied. Embryonic sacs and decidua were collected for each pregnancy. A Human LncRNA Array was employed to profile genomewide lncRNAs, which were then validated by RT-PCR.

ResultsDifferentially expressed lncRNAs were identified. Biological pathways were categorized into six major groups: infection and inflammation, metabolism, signaling and transcriptional regulation, smooth muscle contraction, cell process, and coagulation.

ConclusionsInfection and inflammation pathways regulated by lncRNAs were determined as the predominant pathogenetic factors underlying the SA. Finding that antisense lncRNAs have been either up- or down-regulated suggests that they may have both cis- and trans-regulations.

语种: 英语
项目资助者: Shijiazhuang Maternal and Obstetric Hospital ; March of Dimes Global Network for Maternal and Infant Health (MOD-GNMIH), Peking University Center of Medical Genetics (PUCMG) ; New York State Office for People with Developmental Disabilities (NYS OPWDD)
WOS记录号: WOS:000341883400002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50847
Appears in Collections:基础医学院_北京大学医学遗传中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Med Genet, Beijing 100871, Peoples R China
2.Shijiazhuang Obstet & Maternal Hlth Hosp, Shijiazhuang, Peoples R China
3.Hunter Coll High Sch, New York, NY USA
4.Chinese Alliance Translat Med Maternal & Children, Shijiazhuang, Peoples R China
5.Jiao Tong Univ, Shanghai Childrens Hosp, Shanghai 200030, Peoples R China
6.New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA

Recommended Citation:
Wang, Hong,Cao, Qingying,Ge, Jun,et al. LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion[J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY,2014,72(4):359-375.
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