学科主题基础医学
LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion
Wang, Hong1,2; Cao, Qingying1,2; Ge, Jun1,2; Liu, Chunmiao1; Ma, Yanhong1; Meng, Yuciu1; Wang, Yuxin1; Zhao, Xiaoli1; Liu, Ru1; Li, Caixia1; Wang, Yu3; Zhong, Julia4; Ju, Weina5; Jenkins, Edmund C.5; Brown, W. Ted5; Zhong, Nanbert1,2,3,5,6
关键词Embryonic development first trimester long non-coding RNA (lncRNA) pathogenesis pathways spontaneous abortion
刊名AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
2014-10-01
DOI10.1111/aji.12275
72期:4页:359-375
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Reproductive Biology
研究领域[WOS]Immunology ; Reproductive Biology
关键词[WOS]LONG NONCODING RNA ; GENE-REGULATION ; ANTISENSE RNA ; MICRORNAS ; TRANSCRIPTION ; IDENTIFICATION ; MECHANISMS ; EVOLUTION ; ELEMENTS ; TARGETS
英文摘要

Problem

Spontaneous abortion (SA) occurs before 20 gestational weeks. Approximately, half of recurrent SA has no identifiable cause. No report has yet been investigated the possible involvement of lncRNA in pregnancy loss.

Method of StudySixteen pairs of pregnancies with spontaneous abortions (SA) and induced abortions (IA) were studied. Embryonic sacs and decidua were collected for each pregnancy. A Human LncRNA Array was employed to profile genomewide lncRNAs, which were then validated by RT-PCR.

ResultsDifferentially expressed lncRNAs were identified. Biological pathways were categorized into six major groups: infection and inflammation, metabolism, signaling and transcriptional regulation, smooth muscle contraction, cell process, and coagulation.

ConclusionsInfection and inflammation pathways regulated by lncRNAs were determined as the predominant pathogenetic factors underlying the SA. Finding that antisense lncRNAs have been either up- or down-regulated suggests that they may have both cis- and trans-regulations.

语种英语
WOS记录号WOS:000341883400002
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50847
专题北京大学基础医学院_北京大学医学遗传中心
作者单位1.Peking Univ, Ctr Med Genet, Beijing 100871, Peoples R China
2.Shijiazhuang Obstet & Maternal Hlth Hosp, Shijiazhuang, Peoples R China
3.Hunter Coll High Sch, New York, NY USA
4.Chinese Alliance Translat Med Maternal & Children, Shijiazhuang, Peoples R China
5.Jiao Tong Univ, Shanghai Childrens Hosp, Shanghai 200030, Peoples R China
6.New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA
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Wang, Hong,Cao, Qingying,Ge, Jun,et al. LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion[J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY,2014,72(4):359-375.
APA Wang, Hong.,Cao, Qingying.,Ge, Jun.,Liu, Chunmiao.,Ma, Yanhong.,...&Zhong, Nanbert.(2014).LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion.AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY,72(4),359-375.
MLA Wang, Hong,et al."LncRNA-regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of IncRNAs in Early Spontaneous Abortion".AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 72.4(2014):359-375.
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