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学科主题: 基础医学
题名:
Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice
作者: Wen, Jinhua1; Matsumoto, Kunio1; Taniura, Naoko1; Tomioka, Daisaku1; Nakamura, Toshikazu1
关键词: Met ; colon cancer ; HGF ; liver metastasis ; NK4 ; tumor angiogenesis
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2007-06-22
DOI: 10.1016/j.bbrc.2007.04.098
卷: 358, 期:1, 页:117-123
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: ANTITUMOR-ACTIVITY ; CARCINOMA-CELLS ; C-MET ; FACTOR/SCATTER FACTOR ; 4-KRINGLE ANTAGONIST ; INVASIVE GROWTH ; TUMOR-GROWTH ; HEPATOCYTE ; EXPRESSION ; HGF/NK4
英文摘要:

NK4, originally prepared as a competitive antagonist for hepatocyte growth factor (HGF), is a bifunctional molecule that acts as an HGF-antagonist and angiogenesis inhibitor. When the expression plasmid for NK4 gene was administered into mice by hydrodynamicsbased delivery, the repetitive increase in the plasma NK4 protein level was achieved by repetitive administration of NK4 gene. Mice were subcutaneously implanted with colon cancer cells and weekly given with the NK4 plasmid. The repetitive delivery and expression of NK4 gene inhibited angiogenesis and invasiveness of colon cancer cells in subcutaneous tumor tissue and this was associated with suppression of primary tumor growth. By fifty days after tumor implantation, cancer cells naturally metastasized to the liver, whereas NK4 gene expression potently inhibited liver metastasis. Inhibition of the HGF-Met receptor pathway and tumor angiogenesis by NK4 gene expression has potential therapeutic value toward inhibition of invasion, growth, and metastasis of colon cancer. (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000246790800020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50849
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Osaka Univ, Grad Sch Med, Div Mol Regenerat Med, Dept Biochem & Mol Biol, Suita, Osaka 5650871, Japan
2.Peking Univ, Hlth Sci Ctr, Peking Univ Stem Cell Res Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China

Recommended Citation:
Wen, Jinhua,Matsumoto, Kunio,Taniura, Naoko,et al. Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,358(1):117-123.
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