IR@PKUHSC  > 基础医学院  > 细胞生物学系
学科主题基础医学
Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice
Wen, Jinhua1; Matsumoto, Kunio1; Taniura, Naoko1; Tomioka, Daisaku1; Nakamura, Toshikazu1
关键词Met Colon Cancer Hgf Liver Metastasis Nk4 Tumor Angiogenesis
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2007-06-22
DOI10.1016/j.bbrc.2007.04.098
358期:1页:117-123
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]ANTITUMOR-ACTIVITY ; CARCINOMA-CELLS ; C-MET ; FACTOR/SCATTER FACTOR ; 4-KRINGLE ANTAGONIST ; INVASIVE GROWTH ; TUMOR-GROWTH ; HEPATOCYTE ; EXPRESSION ; HGF/NK4
英文摘要

NK4, originally prepared as a competitive antagonist for hepatocyte growth factor (HGF), is a bifunctional molecule that acts as an HGF-antagonist and angiogenesis inhibitor. When the expression plasmid for NK4 gene was administered into mice by hydrodynamicsbased delivery, the repetitive increase in the plasma NK4 protein level was achieved by repetitive administration of NK4 gene. Mice were subcutaneously implanted with colon cancer cells and weekly given with the NK4 plasmid. The repetitive delivery and expression of NK4 gene inhibited angiogenesis and invasiveness of colon cancer cells in subcutaneous tumor tissue and this was associated with suppression of primary tumor growth. By fifty days after tumor implantation, cancer cells naturally metastasized to the liver, whereas NK4 gene expression potently inhibited liver metastasis. Inhibition of the HGF-Met receptor pathway and tumor angiogenesis by NK4 gene expression has potential therapeutic value toward inhibition of invasion, growth, and metastasis of colon cancer. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000246790800020
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50849
专题基础医学院_细胞生物学系
作者单位1.Osaka Univ, Grad Sch Med, Div Mol Regenerat Med, Dept Biochem & Mol Biol, Suita, Osaka 5650871, Japan
2.Peking Univ, Hlth Sci Ctr, Peking Univ Stem Cell Res Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wen, Jinhua,Matsumoto, Kunio,Taniura, Naoko,et al. Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,358(1):117-123.
APA Wen, Jinhua,Matsumoto, Kunio,Taniura, Naoko,Tomioka, Daisaku,&Nakamura, Toshikazu.(2007).Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,358(1),117-123.
MLA Wen, Jinhua,et al."Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 358.1(2007):117-123.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wen, Jinhua]的文章
[Matsumoto, Kunio]的文章
[Taniura, Naoko]的文章
百度学术
百度学术中相似的文章
[Wen, Jinhua]的文章
[Matsumoto, Kunio]的文章
[Taniura, Naoko]的文章
必应学术
必应学术中相似的文章
[Wen, Jinhua]的文章
[Matsumoto, Kunio]的文章
[Taniura, Naoko]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。