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rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children
Qi, Hui1; Sun, Lin1; Jin, Ya-Qiong1; Shen, Chen1; Chu, Ping1; Wang, Sheng-Feng2; Yin, Qing-Qin1; Qi, Zhan1; Xu, Fang1; Jiao, Wei-Wei1; Wu, Xi-Rong1; Tian, Jian-Ling1; Xiao, Jing1; Shen, A-Dong1
关键词Interleukin-4 Interleukin-10 Polymorphism Tuberculosis Extrapulmonary Tuberculosis Severe Tuberculosis
刊名INFECTION GENETICS AND EVOLUTION
2014-04-01
DOI10.1016/j.meegid.2014.01.031
23页:121-128
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]MYCOBACTERIUM-TUBERCULOSIS ; PULMONARY TUBERCULOSIS ; PEDIATRIC TUBERCULOSIS ; CYTOKINE LEVELS ; T-CELLS ; ACTIVATION ; RESPONSES ; RECEPTOR ; POLYMORPHISMS ; EPIDEMIOLOGY
英文摘要

Interleukin-4 (IL-4) and IL-10, which are produced by Th2 cells, serve as anti-inflammatory cytokines in the immune responses to tuberculosis (TB). In order to investigate the association between susceptibility to TB and single-nucleotide polymorphisms (SNPs) of the IL-4 and IL-10 genes, a case-control study including 346 TB patients and 374 healthy controls was performed in Chinese Han children in North China. Though no significant differences in the allelic and genotypic distributions of SNPs of these two genes were observed between control group and TB group, rs2243268-A and rs2243274-G of the IL-4 gene were associated with reduced risk of developing extrapulmonary tuberculosis (EPTB) (P-rs2243268 = 0.005 and P-rs2243274 = 0.004) and severe TB (P-rs2243268 = 0.003 and Prs2243274 = 0.003). The haplotype comprising rs2243268-A and rs2243274-G was found to be a resistance factor against EPTB and severe TB. In addition, after stimulation with inactivated H37Rv, blood samples of the rs2243268 AA + AC carriers showed significantly reduced IL-10 production (P = 0.045) compared to the CC carriers. In conclusion, rs2243268-A and rs2243274-G of the IL-4 gene were found to confer resistance to EPTB and severe TB in Chinese Han children. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000335107100016
项目编号7121007 ; 30901632
资助机构Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Post-doctoral Research Foundation ; China Postdoctoral Science Foundation
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50850
专题北京大学公共卫生学院
北京大学公共卫生学院_公共卫生学院
作者单位1.Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children & Natl Key Discipline, Minist Educ,Beijing Pediat Res Inst, Beijing 100045, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
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GB/T 7714
Qi, Hui,Sun, Lin,Jin, Ya-Qiong,et al. rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children[J]. INFECTION GENETICS AND EVOLUTION,2014,23:121-128.
APA Qi, Hui.,Sun, Lin.,Jin, Ya-Qiong.,Shen, Chen.,Chu, Ping.,...&Shen, A-Dong.(2014).rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children.INFECTION GENETICS AND EVOLUTION,23,121-128.
MLA Qi, Hui,et al."rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children".INFECTION GENETICS AND EVOLUTION 23(2014):121-128.
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