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学科主题: 公共卫生
题名:
rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children
作者: Qi, Hui1; Sun, Lin1; Jin, Ya-Qiong1; Shen, Chen1; Chu, Ping1; Wang, Sheng-Feng2; Yin, Qing-Qin1; Qi, Zhan1; Xu, Fang1; Jiao, Wei-Wei1; Wu, Xi-Rong1; Tian, Jian-Ling1; Xiao, Jing1; Shen, A-Dong1
关键词: Interleukin-4 ; Interleukin-10 ; Polymorphism ; Tuberculosis ; Extrapulmonary tuberculosis ; Severe tuberculosis
刊名: INFECTION GENETICS AND EVOLUTION
发表日期: 2014-04-01
DOI: 10.1016/j.meegid.2014.01.031
卷: 23, 页:121-128
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: MYCOBACTERIUM-TUBERCULOSIS ; PULMONARY TUBERCULOSIS ; PEDIATRIC TUBERCULOSIS ; CYTOKINE LEVELS ; T-CELLS ; ACTIVATION ; RESPONSES ; RECEPTOR ; POLYMORPHISMS ; EPIDEMIOLOGY
英文摘要:

Interleukin-4 (IL-4) and IL-10, which are produced by Th2 cells, serve as anti-inflammatory cytokines in the immune responses to tuberculosis (TB). In order to investigate the association between susceptibility to TB and single-nucleotide polymorphisms (SNPs) of the IL-4 and IL-10 genes, a case-control study including 346 TB patients and 374 healthy controls was performed in Chinese Han children in North China. Though no significant differences in the allelic and genotypic distributions of SNPs of these two genes were observed between control group and TB group, rs2243268-A and rs2243274-G of the IL-4 gene were associated with reduced risk of developing extrapulmonary tuberculosis (EPTB) (P-rs2243268 = 0.005 and P-rs2243274 = 0.004) and severe TB (P-rs2243268 = 0.003 and Prs2243274 = 0.003). The haplotype comprising rs2243268-A and rs2243274-G was found to be a resistance factor against EPTB and severe TB. In addition, after stimulation with inactivated H37Rv, blood samples of the rs2243268 AA + AC carriers showed significantly reduced IL-10 production (P = 0.045) compared to the CC carriers. In conclusion, rs2243268-A and rs2243274-G of the IL-4 gene were found to confer resistance to EPTB and severe TB in Chinese Han children. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 7121007 ; 30901632
项目资助者: Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Post-doctoral Research Foundation ; China Postdoctoral Science Foundation
WOS记录号: WOS:000335107100016
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50850
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children & Natl Key Discipline, Minist Educ,Beijing Pediat Res Inst, Beijing 100045, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Qi, Hui,Sun, Lin,Jin, Ya-Qiong,et al. rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children[J]. INFECTION GENETICS AND EVOLUTION,2014,23:121-128.
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