北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Tumor specific delivery with redox-triggered mesoporous silica nanoparticles inducing neovascularization suppression and vascular normalization
作者: Sun, Lu1,2; Liu, Yu-Jie1,2; Yang, Zhen-Zhen2; Qi, Xian-Rong1,2,3
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c5ra09633b
卷: 5, 期:68, 页:55566-55578
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: DRUG-DELIVERY ; GENE DELIVERY ; SOLID TUMORS ; CANCER ; SIRNA ; NANOCARRIERS ; DISEASES ; THERAPY ; GROWTH ; CELLS
英文摘要:

RNA interference (RNAi) has great potential in cancer therapy, however, efficient cytoplasmic delivery still remains a major challenge. In this study, redox-responsive mesoporous silica nanoparticles with enlarged pores (denoted as MSN-siRNA/CrPEI) were designed by immobilizing polyethylenimine (PEI) via intermediate linkers of disulfide bonds onto the MSNs as caps for redox-responsive intracellular gene delivery. The MSN-siRNA/CrPEI with a high siRNA loading capacity (35 mg siRNA per g MSNs) could react to the specific reductive stimulation-upgraded glutathione concentration in tumor cells and release cargos through the rupture of disulfide bonds. Subsequently, MSN-siRNA/CrPEI was used to deliver VEGF siRNA for cancer therapy and the underlying mechanisms were explored. As we expected, MSN-siRNA/CrPEI could be readily internalized into cells, escaped from the endolysosomes and was distributed in the cytoplasm where siRNA mediated its function. MSN-siRNA/CrPEI showed remarkable anti-tumor efficacy by the suppression of neovascularization and vascular normalization after peritumoral application against mice with KB tumors, proved by interstitial fluid pressure (IFP) reduction, CD31 suppression and angioplerosis. Notably, siRNA combined with dexamethasone exerted a better treatment effect which is attributed to the strong capability of dexamethasone to decrease the IFP, and a lower IFP leads to an improvement in the delivery and efficacy of exogenously administered therapeutics. These results indicate that the tumor specific delivery of siRNA with redox-triggered mesoporous silica nanoparticles is a promising strategy to enhance therapeutic efficacy. Neovascularization suppression and vascular normalization may be beneficial for cancer inhibition.

语种: 英语
所属项目编号: 2013CB932501 ; 81273454 ; 81473156 ; 7132113 ; 20130001110055
项目资助者: National Key Basic Research Program ; NSFC ; Beijing NSF ; Doctoral Foundation of the Ministry of Education
WOS记录号: WOS:000357051100096
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50855
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Lu,Liu, Yu-Jie,Yang, Zhen-Zhen,et al. Tumor specific delivery with redox-triggered mesoporous silica nanoparticles inducing neovascularization suppression and vascular normalization[J]. RSC ADVANCES,2015,5(68):55566-55578.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Lu]'s Articles
[Liu, Yu-Jie]'s Articles
[Yang, Zhen-Zhen]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Lu]‘s Articles
[Liu, Yu-Jie]‘s Articles
[Yang, Zhen-Zhen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace