IR@PKUHSC  > 北京大学药学院
学科主题药学
Tumor specific delivery with redox-triggered mesoporous silica nanoparticles inducing neovascularization suppression and vascular normalization
Sun, Lu1,2; Liu, Yu-Jie1,2; Yang, Zhen-Zhen2; Qi, Xian-Rong1,2,3
刊名RSC ADVANCES
2015
DOI10.1039/c5ra09633b
5期:68页:55566-55578
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]DRUG-DELIVERY ; GENE DELIVERY ; SOLID TUMORS ; CANCER ; SIRNA ; NANOCARRIERS ; DISEASES ; THERAPY ; GROWTH ; CELLS
英文摘要

RNA interference (RNAi) has great potential in cancer therapy, however, efficient cytoplasmic delivery still remains a major challenge. In this study, redox-responsive mesoporous silica nanoparticles with enlarged pores (denoted as MSN-siRNA/CrPEI) were designed by immobilizing polyethylenimine (PEI) via intermediate linkers of disulfide bonds onto the MSNs as caps for redox-responsive intracellular gene delivery. The MSN-siRNA/CrPEI with a high siRNA loading capacity (35 mg siRNA per g MSNs) could react to the specific reductive stimulation-upgraded glutathione concentration in tumor cells and release cargos through the rupture of disulfide bonds. Subsequently, MSN-siRNA/CrPEI was used to deliver VEGF siRNA for cancer therapy and the underlying mechanisms were explored. As we expected, MSN-siRNA/CrPEI could be readily internalized into cells, escaped from the endolysosomes and was distributed in the cytoplasm where siRNA mediated its function. MSN-siRNA/CrPEI showed remarkable anti-tumor efficacy by the suppression of neovascularization and vascular normalization after peritumoral application against mice with KB tumors, proved by interstitial fluid pressure (IFP) reduction, CD31 suppression and angioplerosis. Notably, siRNA combined with dexamethasone exerted a better treatment effect which is attributed to the strong capability of dexamethasone to decrease the IFP, and a lower IFP leads to an improvement in the delivery and efficacy of exogenously administered therapeutics. These results indicate that the tumor specific delivery of siRNA with redox-triggered mesoporous silica nanoparticles is a promising strategy to enhance therapeutic efficacy. Neovascularization suppression and vascular normalization may be beneficial for cancer inhibition.

语种英语
WOS记录号WOS:000357051100096
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50855
Collection北京大学药学院
北京大学药学院_药剂学系
作者单位1.Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Sun, Lu,Liu, Yu-Jie,Yang, Zhen-Zhen,et al. Tumor specific delivery with redox-triggered mesoporous silica nanoparticles inducing neovascularization suppression and vascular normalization[J]. RSC ADVANCES,2015,5(68):55566-55578.
APA Sun, Lu,Liu, Yu-Jie,Yang, Zhen-Zhen,&Qi, Xian-Rong.(2015).Tumor specific delivery with redox-triggered mesoporous silica nanoparticles inducing neovascularization suppression and vascular normalization.RSC ADVANCES,5(68),55566-55578.
MLA Sun, Lu,et al."Tumor specific delivery with redox-triggered mesoporous silica nanoparticles inducing neovascularization suppression and vascular normalization".RSC ADVANCES 5.68(2015):55566-55578.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Sun, Lu]'s Articles
[Liu, Yu-Jie]'s Articles
[Yang, Zhen-Zhen]'s Articles
百度学术
百度学术Similar articles in
[Sun, Lu]'s Articles
[Liu, Yu-Jie]'s Articles
[Yang, Zhen-Zhen]'s Articles
必应学术
必应学术Similar articles in
[Sun, Lu]'s Articles
[Liu, Yu-Jie]'s Articles
[Yang, Zhen-Zhen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.