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学科主题: 公共卫生
题名:
Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration
作者: Chen, Wen2; Xu, Wei1; Tao, Qiushan3; Liu, Juan2; Li, Xiaojing1; Gan, Xiumin1; Hu, Honglin1; Lu, Yunxia1
关键词: age-related macular degeneration (AMD) ; HTRA1 ; meta-analysis
刊名: EXPERIMENTAL EYE RESEARCH
发表日期: 2009-09-01
DOI: 10.1016/j.exer.2008.10.017
卷: 89, 期:3, 页:292-300
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: JAPANESE POPULATION ; VARIANT ; SUSCEPTIBILITY ; DISEASE
英文摘要:

HTRA1 was considered as one of important age-related macular degeneration (AMD) candidate genes. However, due to population heterogeneity and bias from case-control study, the association between HTRA1 and AMD needs further confirmation across different studies in different population. In this study, a meta-analysis was performed in 14 case-control studies which were published before August 31, 2008. Effect of HTRA1 polymorphism with AMD was synthetically evaluated. The pooled odds ratio (OR) for heterozygous genotype GA versus wild homozygous genotype GG is 2.13 (95% CI: 1.90, 2.39), the OR of homozygous genotype AA versus GG is 6.92 (95% CI: 5.74, 8.34) and the OR of allele A carrier (GA + AA) versus GG is 3.02 (95% CI: 2.57, 3.53). Sub-analysis indicated that the risk of HTRA1 rs11200638 on wet AMD was stronger than dry AMD, and it seems that HTRA1 rs11200638 could increase the risk of AMD in all races. This study strengthens the hypothesis of association between rs11200638 in the promoter of HTRA1 polymorphism and AMD. The variant of HTRA1/625G -> A could be a potentially promising genetic biomarker of AMD. (c) 2008 Published by Elsevier Ltd.

语种: 英语
所属项目编号: D43 TW06176
项目资助者: NIH/FIC
WOS记录号: WOS:000269041900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50856
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Union Hosp, Dept Ophthalmol, Wuhan 430022, Hubei, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Wen,Xu, Wei,Tao, Qiushan,et al. Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration[J]. EXPERIMENTAL EYE RESEARCH,2009,89(3):292-300.
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