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Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration
Chen, Wen2; Xu, Wei1; Tao, Qiushan3; Liu, Juan2; Li, Xiaojing1; Gan, Xiumin1; Hu, Honglin1; Lu, Yunxia1
关键词Age-related Macular Degeneration (Amd) Htra1 Meta-analysis
刊名EXPERIMENTAL EYE RESEARCH
2009-09-01
DOI10.1016/j.exer.2008.10.017
89期:3页:292-300
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]JAPANESE POPULATION ; VARIANT ; SUSCEPTIBILITY ; DISEASE
英文摘要

HTRA1 was considered as one of important age-related macular degeneration (AMD) candidate genes. However, due to population heterogeneity and bias from case-control study, the association between HTRA1 and AMD needs further confirmation across different studies in different population. In this study, a meta-analysis was performed in 14 case-control studies which were published before August 31, 2008. Effect of HTRA1 polymorphism with AMD was synthetically evaluated. The pooled odds ratio (OR) for heterozygous genotype GA versus wild homozygous genotype GG is 2.13 (95% CI: 1.90, 2.39), the OR of homozygous genotype AA versus GG is 6.92 (95% CI: 5.74, 8.34) and the OR of allele A carrier (GA + AA) versus GG is 3.02 (95% CI: 2.57, 3.53). Sub-analysis indicated that the risk of HTRA1 rs11200638 on wet AMD was stronger than dry AMD, and it seems that HTRA1 rs11200638 could increase the risk of AMD in all races. This study strengthens the hypothesis of association between rs11200638 in the promoter of HTRA1 polymorphism and AMD. The variant of HTRA1/625G -> A could be a potentially promising genetic biomarker of AMD. (c) 2008 Published by Elsevier Ltd.

语种英语
WOS记录号WOS:000269041900003
项目编号D43 TW06176
资助机构NIH/FIC
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50856
专题北京大学公共卫生学院
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Union Hosp, Dept Ophthalmol, Wuhan 430022, Hubei, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
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GB/T 7714
Chen, Wen,Xu, Wei,Tao, Qiushan,et al. Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration[J]. EXPERIMENTAL EYE RESEARCH,2009,89(3):292-300.
APA Chen, Wen.,Xu, Wei.,Tao, Qiushan.,Liu, Juan.,Li, Xiaojing.,...&Lu, Yunxia.(2009).Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration.EXPERIMENTAL EYE RESEARCH,89(3),292-300.
MLA Chen, Wen,et al."Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration".EXPERIMENTAL EYE RESEARCH 89.3(2009):292-300.
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