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学科主题: 临床医学
题名:
Over-expression of metastasis-associated in colon cancer-1 (MACC1) associates with better prognosis of gastric cancer patients
作者: Ge, Shao-hua1; Wu, Xiao-jiang1; Wang, Xiao-hong1; Xing, Xiao-fang1; Zhang, Lian-hai1; Zhu, Yu-bing1; Du, Hong1; Dong, Bin2; Hu, Ying3; Ji, Jia-fu1
关键词: MACC1 ; Gastric cancer ; Prognosis
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2011-06-01
DOI: 10.1007/s11670-011-0153-9
卷: 23, 期:2, 页:153-159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: C-MET EXPRESSION ; SURGICAL-TREATMENT ; TUMOR-MARKER ; CELLS ; CEA ; SERUM ; OVEREXPRESSION ; AMPLIFICATION ; ACTIVATION ; CARCINOMA
英文摘要:

The aim of this study was to detect metastasis-associated in colon cancer-1 (MACC1) expression in Chinese gastric cancer and analyze the relationship between MACC1 expression and postoperative survival.

The expression of MACC1 and c-MET protein in a sample of 128 gastric cancer tissues was detected by immunohistochemistry. A retrospective cohort study on the prognosis was carried out and data were collected from medical records.

The positive rate of MACC1 protein expression in gastric cancer was 47.66%, higher than that in adjacent noncancerous mucosa (P < 0.001). MACC1 protein expression was not related to the clinicopathological variables involved. Kaplan-Meier analysis revealed that the survival of MACC1 positive group tended to be better than that of MACC1 negative group, particularly in patients with stage III carcinoma (P=0.032). Cox regression analysis revealed that MACC1 protein over-expression in gastric cancer tended to be a protective factor with hazard ratio of 0.621 (P=0.057). Immunohistochemical analysis showed that the positive rate of c-MET protein expression was much higher in cases with positive MACC1 expression in gastric cancer (P=0.002), but P53 expression was not associated with MACC1 expression.

MACC1 over-expression implies better survival and may be an independent prognostic factor for gastric cancer in Chinese patients.

语种: 英语
所属项目编号: D0905001040631
项目资助者: Foundation from Beijing Municipal Committee of Science and Technology ; Scientific Research Foundation for the Returned Overseas Chinese Scholars from Ministry of Education of China
WOS记录号: WOS:000290804600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50860
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Gastrointestinal Su, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Tissue Bank, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Ge, Shao-hua,Wu, Xiao-jiang,Wang, Xiao-hong,et al. Over-expression of metastasis-associated in colon cancer-1 (MACC1) associates with better prognosis of gastric cancer patients[J]. CHINESE JOURNAL OF CANCER RESEARCH,2011,23(2):153-159.
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