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学科主题: 临床医学
题名:
Obesity and chronic kidney disease in patients with chronic heart failure: an insight from the China Heart Survey
作者: Liu, Hao1,2; Shi, Hong3; Yu, Jinming1,2; Chen, Fang4; Jiang, Qingwu1,2; Hu, Dayi5
关键词: Heart failure ; Obesity ; Central obesity ; Chronic kidney disease
刊名: CLINICAL AND EXPERIMENTAL NEPHROLOGY
发表日期: 2011-08-01
DOI: 10.1007/s10157-011-0443-z
卷: 15, 期:4, 页:522-528
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: BODY-MASS INDEX ; CORONARY-ARTERY-DISEASE ; WAIST CIRCUMFERENCE ; METABOLIC SYNDROME ; HIGH PREVALENCE ; MORTALITY ; OUTCOMES ; PARADOX ; ADULTS ; RISK
英文摘要:

Background Obesity and decreased kidney function have been shown to be prevalent in Western patients with heart failure; however, whether this phenomenon exists in Chinese patients with chronic heart failure (CHF) is not known.

Methods and results One thousand and nine patients with CHF from the China Heart Survey were assessed. The prevalence of chronic kidney disease (CKD) was 34.2%, and there was a stepwise increase in the prevalence of CKD with New York Heart Association (NYHA) classes (P < 0.001). Moreover, patients with CKD had a significantly elevated risk for developing severe extent of CHF (OR = 1.69, 95% CI: 1.27-2.24, P < 0.001). The prevalence of obesity and central obesity was 35.7% and 62.5%, respectively. Notably, there was a downward trend in the prevalence of obesity with advanced NYHA classes (trend test, P = 0.003). Multivariate analysis further supported the finding that obesity, but not central obesity, was inversely associated with the extent of CHF (OR = 0.72, 95% CI: 0.55-0.94, P = 0.017).

Conclusions Renal dysfunction is common in Chinese patients with CHF and is independently associated with advanced NYHA classes. Obesity was inversely associated with the extent of CHF, which further supports the notion that obesity confers improved prognosis in patients with heart failure.

语种: 英语
WOS记录号: WOS:000293976600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50864
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Fudan Univ, Clin Res Inst, Sch Publ Hlth, Shanghai 200032, Peoples R China
2.Fudan Univ, Key Lab Publ Hlth Safety, Minist Educ, Shanghai 200032, Peoples R China
3.Fourth Mil Med Univ, Tangdu Hosp, Xian 710032, Peoples R China
4.Tongji Univ, Sch Med, Dept Prevent Med, Shanghai 200092, Peoples R China
5.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Hao,Shi, Hong,Yu, Jinming,et al. Obesity and chronic kidney disease in patients with chronic heart failure: an insight from the China Heart Survey[J]. CLINICAL AND EXPERIMENTAL NEPHROLOGY,2011,15(4):522-528.
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