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Association between thrombelastography system and thromboembolic and bleeding events in Chinese aged people
Bai, Jie1; Zheng, Qi-Wen2; Fu, Shu-Hong1; Li, Xiao-Xia1; Li, Yu-Ru1; Zhou, Yu1; Yu, Ji-Hong1; Gong, Mei-Liang1; Chen, Da-Fang2
关键词Thrombelastography (Teg) Thromboembolic Event Bleeding Chinese Aged Population Structural Equation Modeling (Sem)
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2013
6期:4页:310-319
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]THROMBOELASTOGRAPHY ; HYPERCOAGULABILITY ; COAGULABILITY ; HEMOSTASIS ; THROMBOSIS ; SURGERY
英文摘要

Objectives: This study was designed to obtain the knowledge about TEG indexes distribution in Chinese aged people, as well as to test the hypothesis that previous TEG indexes are associated with the subsequent thromboembolic and bleeding events in the aged population. Methods: We conducted a two-year follow-up study in Chinese PLA General Hospital, Beijing, China. 403 aged people were enrolled in our study. They received TEG measurements at least once when they entered this study. We collected their demographical characteristics, clinical examination information and their outcome during their observational period. Structural equation modeling (SEM) was used to analyze the relationship between the four indexes from TEG and the outcome via a pathway of indicator. Results: We found that in the "model of bleeding" (adjusted by confounding of Anticoagulants), the model fit indices with chi-square/df = 9.555/7, CFI was 0.997, TLI was 0.994 and standardized root mean square residual (SRMR) was 0.034; while in the "model of thromboembolic events" (adjusted by confounding of Anticoagulants), the model fit indices with chi-square/df = 6.070/7, CFI was 1.000, TLI was 1.002 and standardized root mean square residual (SRMR) was 0.000. The "model of thromboembolic events" showed that the four indexes (R, K, MA and ANGLE) were all significantly associated with thromboembolic events, while this significance was not found in the "model of bleeding". Conclusions: Previous TEG indexes are significantly associated with the subsequent thromboembolic events in the aged population. Future study can test this association and provide more information for the clinical use.

语种英语
WOS记录号WOS:000318545300011
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50871
专题北京大学公共卫生学院
北京大学基础医学院
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Nanlou Clin Lab, Beijing 100853, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China
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GB/T 7714
Bai, Jie,Zheng, Qi-Wen,Fu, Shu-Hong,et al. Association between thrombelastography system and thromboembolic and bleeding events in Chinese aged people[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2013,6(4):310-319.
APA Bai, Jie.,Zheng, Qi-Wen.,Fu, Shu-Hong.,Li, Xiao-Xia.,Li, Yu-Ru.,...&Chen, Da-Fang.(2013).Association between thrombelastography system and thromboembolic and bleeding events in Chinese aged people.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,6(4),310-319.
MLA Bai, Jie,et al."Association between thrombelastography system and thromboembolic and bleeding events in Chinese aged people".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 6.4(2013):310-319.
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