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学科主题: 公共卫生
题名:
Association between thrombelastography system and thromboembolic and bleeding events in Chinese aged people
作者: Bai, Jie1; Zheng, Qi-Wen2; Fu, Shu-Hong1; Li, Xiao-Xia1; Li, Yu-Ru1; Zhou, Yu1; Yu, Ji-Hong1; Gong, Mei-Liang1; Chen, Da-Fang2
关键词: Thrombelastography (TEG) ; thromboembolic event ; bleeding ; Chinese aged population ; structural equation modeling (SEM)
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2013
卷: 6, 期:4, 页:310-319
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: THROMBOELASTOGRAPHY ; HYPERCOAGULABILITY ; COAGULABILITY ; HEMOSTASIS ; THROMBOSIS ; SURGERY
英文摘要:

Objectives: This study was designed to obtain the knowledge about TEG indexes distribution in Chinese aged people, as well as to test the hypothesis that previous TEG indexes are associated with the subsequent thromboembolic and bleeding events in the aged population. Methods: We conducted a two-year follow-up study in Chinese PLA General Hospital, Beijing, China. 403 aged people were enrolled in our study. They received TEG measurements at least once when they entered this study. We collected their demographical characteristics, clinical examination information and their outcome during their observational period. Structural equation modeling (SEM) was used to analyze the relationship between the four indexes from TEG and the outcome via a pathway of indicator. Results: We found that in the "model of bleeding" (adjusted by confounding of Anticoagulants), the model fit indices with chi-square/df = 9.555/7, CFI was 0.997, TLI was 0.994 and standardized root mean square residual (SRMR) was 0.034; while in the "model of thromboembolic events" (adjusted by confounding of Anticoagulants), the model fit indices with chi-square/df = 6.070/7, CFI was 1.000, TLI was 1.002 and standardized root mean square residual (SRMR) was 0.000. The "model of thromboembolic events" showed that the four indexes (R, K, MA and ANGLE) were all significantly associated with thromboembolic events, while this significance was not found in the "model of bleeding". Conclusions: Previous TEG indexes are significantly associated with the subsequent thromboembolic events in the aged population. Future study can test this association and provide more information for the clinical use.

语种: 英语
WOS记录号: WOS:000318545300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50871
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Nanlou Clin Lab, Beijing 100853, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Bai, Jie,Zheng, Qi-Wen,Fu, Shu-Hong,et al. Association between thrombelastography system and thromboembolic and bleeding events in Chinese aged people[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2013,6(4):310-319.
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