|Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?|
|Zhu, Jinliang1,2,3; Lian, Ying1,2,3; Li, Ming1,2,3; Chen, Lixue1,2,3; Liu, Ping1,2,3; Qiao, Jie1,2,3|
|关键词||Embryo Quality Pregnancy Complications Miscarriage Singleton Gestations Ivf/icsi|
|刊名||JOURNAL OF ASSISTED REPRODUCTION AND GENETICS|
|WOS标题词||Science & Technology|
|类目[WOS]||Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology|
|研究领域[WOS]||Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology|
|关键词[WOS]||IN-VITRO FERTILIZATION ; ASSISTED REPRODUCTION TECHNOLOGY ; POLYCYSTIC-OVARY-SYNDROME ; BIRTH-DEFECTS ; CHILDREN BORN ; TROPHECTODERM MORPHOLOGY ; BLASTOCYST TRANSFER ; PERINATAL OUTCOMES ; MATERNAL FACTORS ; METAANALYSIS|
Purposes Embryo quality is associated with successful implantation and live births. Our retrospective study was carried out to determine whether or not cleavage stage embryo quality affects the miscarriage rate, pregnancy complications and neonatal outcomes of singletons conceived with assisted reproduction technology.
Method The current study included 11,721 In Vitro Fertilization-Embryo Transfer cycles (IVF-ET) between January 2009 (the date at which electronic medical records were implemented at our center) and March 2013. Only women<40 years of age undergoing their first fresh embryo transfer cycle using non-donor oocytes were included.
Results Our study indicated that the transfer of poor-quality embryos resulted in higher miscarriage (19.77 % vs. 13.28 %, p=0.02) and lower ongoing pregnancy rates (15.33 % vs. 48.06 %, p<0.001). Logistic regression analysis performed on data derived from 744 cycles culminating in miscarriages versus 4,333 cycles culminating in live births, suggested that embryo quality (p=0.04) is significantly associated with miscarriage rate after adjusting for other confounding factors. Moreover, there were no differences in the mean birth weight, low birth weight (<2,500 g), very low birth weight (<1,500 g), gestational age, preterm delivery (<37 weeks), very preterm delivery (<32 weeks), congenital malformations, small-for-gestational-age singletons (SGA), and large-for-gestational-age singleton (LGA) rate (p>0.05). Similarly, pregnancy complications resulting from poor-quality embryos were not different from good-quality embryos (4.04 % vs. 2.57 %, p=0.33). Finally, logistic regression suggested that embryo quality was not significantly associated with pregnancy complications after adjusting for other confounding factors (p=0.40).
Conclusions Our study suggests that transfer of poor-quality embryos did not increase the risk of adverse outcomes; however, the quality of cleavage stage embryos significantly affected the miscarriage rate and ongoing pregnancies.
|资助机构||National Natural Science Foundation of China|
|作者单位||1.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China|
2.Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
|Zhu, Jinliang,Lian, Ying,Li, Ming,et al. Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2014,31(12):1635-1641.|
|APA||Zhu, Jinliang,Lian, Ying,Li, Ming,Chen, Lixue,Liu, Ping,&Qiao, Jie.(2014).Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,31(12),1635-1641.|
|MLA||Zhu, Jinliang,et al."Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 31.12(2014):1635-1641.|