IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心
学科主题临床医学
Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?
Zhu, Jinliang1,2,3; Lian, Ying1,2,3; Li, Ming1,2,3; Chen, Lixue1,2,3; Liu, Ping1,2,3; Qiao, Jie1,2,3
关键词Embryo Quality Pregnancy Complications Miscarriage Singleton Gestations Ivf/icsi
刊名JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
2014-12-01
DOI10.1007/s10815-014-0351-8
31期:12页:1635-1641
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]IN-VITRO FERTILIZATION ; ASSISTED REPRODUCTION TECHNOLOGY ; POLYCYSTIC-OVARY-SYNDROME ; BIRTH-DEFECTS ; CHILDREN BORN ; TROPHECTODERM MORPHOLOGY ; BLASTOCYST TRANSFER ; PERINATAL OUTCOMES ; MATERNAL FACTORS ; METAANALYSIS
英文摘要

Purposes Embryo quality is associated with successful implantation and live births. Our retrospective study was carried out to determine whether or not cleavage stage embryo quality affects the miscarriage rate, pregnancy complications and neonatal outcomes of singletons conceived with assisted reproduction technology.

Method The current study included 11,721 In Vitro Fertilization-Embryo Transfer cycles (IVF-ET) between January 2009 (the date at which electronic medical records were implemented at our center) and March 2013. Only women<40 years of age undergoing their first fresh embryo transfer cycle using non-donor oocytes were included.

Results Our study indicated that the transfer of poor-quality embryos resulted in higher miscarriage (19.77 % vs. 13.28 %, p=0.02) and lower ongoing pregnancy rates (15.33 % vs. 48.06 %, p<0.001). Logistic regression analysis performed on data derived from 744 cycles culminating in miscarriages versus 4,333 cycles culminating in live births, suggested that embryo quality (p=0.04) is significantly associated with miscarriage rate after adjusting for other confounding factors. Moreover, there were no differences in the mean birth weight, low birth weight (<2,500 g), very low birth weight (<1,500 g), gestational age, preterm delivery (<37 weeks), very preterm delivery (<32 weeks), congenital malformations, small-for-gestational-age singletons (SGA), and large-for-gestational-age singleton (LGA) rate (p>0.05). Similarly, pregnancy complications resulting from poor-quality embryos were not different from good-quality embryos (4.04 % vs. 2.57 %, p=0.33). Finally, logistic regression suggested that embryo quality was not significantly associated with pregnancy complications after adjusting for other confounding factors (p=0.40).

Conclusions Our study suggests that transfer of poor-quality embryos did not increase the risk of adverse outcomes; however, the quality of cleavage stage embryos significantly affected the miscarriage rate and ongoing pregnancies.

语种英语
WOS记录号WOS:000345766000009
项目编号81300483
资助机构National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50874
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Jinliang,Lian, Ying,Li, Ming,et al. Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2014,31(12):1635-1641.
APA Zhu, Jinliang,Lian, Ying,Li, Ming,Chen, Lixue,Liu, Ping,&Qiao, Jie.(2014).Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,31(12),1635-1641.
MLA Zhu, Jinliang,et al."Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 31.12(2014):1635-1641.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhu, Jinliang]的文章
[Lian, Ying]的文章
[Li, Ming]的文章
百度学术
百度学术中相似的文章
[Zhu, Jinliang]的文章
[Lian, Ying]的文章
[Li, Ming]的文章
必应学术
必应学术中相似的文章
[Zhu, Jinliang]的文章
[Lian, Ying]的文章
[Li, Ming]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。