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学科主题临床医学
Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial
Li, Ya-Wei1; Li, Hui-Juan2; Li, Huai-Jin1; Feng, Yi3; Yu, Yao3; Guo, Xiang-Yang4; Li, Yan4; Zhao, Bin-Jiang5; Hu, Xiao-Yun5; Zuo, Ming-Zhang6; Zhang, Hong-Ye6; Wang, Mei-Rong2; Ji, Ping2; Yan, Xiao-Yan2; Wu, Yang-Feng2; Wang, Dong-Xin1
关键词Aged Surgical Procedures Anesthesia Epidural Analgesia Epidural Postoperative Complications Delirium
刊名BMC ANESTHESIOLOGY
2015-10-13
DOI10.1186/s12871-015-0118-5
15
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anesthesiology
研究领域[WOS]Anesthesiology
关键词[WOS]INTENSIVE-CARE-UNIT ; CONFUSION ASSESSMENT METHOD ; CRITICALLY-ILL PATIENTS ; MECHANICALLY VENTILATED PATIENTS ; AGITATION-SEDATION SCALE ; MENTAL-STATE-EXAMINATION ; POPULATION-BASED COHORT ; EPIDURAL-ANESTHESIA ; NONCARDIAC SURGERY ; RISK-FACTORS
英文摘要

Background: Delirium is a common complication in elderly patients after surgery and associated with increased morbidity and mortality. Studies suggest that deep anesthesia and intense pain are important precipitating factors of postoperative delirium. Neuraxial block is frequently used in combination with general anesthesia for patients undergoing major thoracic and abdominal surgery. Compared with general anesthesia alone and postoperative intravenous analgesia, combined epidural-general anesthesia and postoperative epidural analgesia decreases the requirement of general anesthetics during surgery and provided better pain relief after surgery. However, whether combined epidural-general anesthesia plus epidural analgesia is superior to general anesthesia plus intravenous analgesia in decreasing the incidence of postoperative delirium remains unknown.

Methods/design: This is a multicenter, open-label, randomized, parallel-controlled clinical trial. One thousand eight hundred elderly patients (age range 60-90 years) who are scheduled to undergo major thoracic or abdominal surgery are randomized to receive either general anesthesia plus postoperative intravenous analgesia or combined epidural-general anesthesia plus postoperative epidural analgesia. The primary outcome is the 7-day incidence of postoperative delirium. Secondary outcomes include the duration of postoperative delirium, the intensity of pain during the first three days after surgery, the 30-day incidences of postoperative non-delirium complications, the length of stay in hospital after surgery and 30-day all-cause mortality.

Discussion: Results of the present study will provide information to guide clinical practice in choosing appropriate anesthesia-analgesia method for elderly patients undergoing major thoracic and abdominal surgery.

语种英语
WOS记录号WOS:000362535900001
项目编号PUCRP201101
资助机构Fundamental Research Funds for the Central Universities-Peking University Clinical Research Program in Peking University Health Science Center ; Peking University First Hospital
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50879
专题北京大学第一临床医学院
北京大学第一临床医学院_麻醉科
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Clin Res Inst, Beijing 100191, Peoples R China
2.Beijing Shijitan Hosp, Dept Anesthesiol, Beijing 100038, Peoples R China
3.Beijing Hosp, Dept Anesthesiol, Beijing 100730, Peoples R China
4.Peking Univ, Hosp 1, Dept Anesthesiol & Crit Care Med, Beijing 100034, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Anesthesiol, Beijing 100044, Peoples R China
6.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Ya-Wei,Li, Hui-Juan,Li, Huai-Jin,et al. Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial[J]. BMC ANESTHESIOLOGY,2015,15.
APA Li, Ya-Wei.,Li, Hui-Juan.,Li, Huai-Jin.,Feng, Yi.,Yu, Yao.,...&Wang, Dong-Xin.(2015).Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial.BMC ANESTHESIOLOGY,15.
MLA Li, Ya-Wei,et al."Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial".BMC ANESTHESIOLOGY 15(2015).
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