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A cluster of polypyrimidine tracts is involved in the transcription regulation of telomerase transcriptional elements-interacting factor
Sun, Ying; Sun, Qian; McNutt, Michael A.; Gong, Yilei; Wang, Jiaochen; Hou, Lin; Shen, Qi; Ling, Yun; Chi, Yingkai; Zhang, Bo
关键词Transcriptional regulation TEIF PTB1 DNA damage
刊名MOLECULAR AND CELLULAR BIOCHEMISTRY
2009-07-01
DOI10.1007/s11010-009-0043-3
327期:1-2页:65-73
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
资助者National Natural Science Foundation of China ; Doctors Program of Chinese Education Ministry ; National Natural Science Foundation of China ; Doctors Program of Chinese Education Ministry
研究领域[WOS]Cell Biology
关键词[WOS]BINDING-PROTEIN ; G-QUADRUPLEX ; HNRNP-K ; PROMOTER ; TRANSLATION ; GENE
英文摘要

In a previous study, we demonstrated that telomerase transcriptional elements-interacting factor (TEIF) could up-regulate the expression of telomerase and DNA polymerase beta, increasing resistance to genotoxic agents. Here, we further report that TEIF can be stimulated by DNA damage and we have identified a cluster of repeated polypyrimidine tracts in the promoter of TEIF, which mediate both its basal transcription and its response to genotoxic agents. These polypyrimidine tracts are arranged in three types of repeating units and in each of these units there are 14 bp length tandem sequences, which are repeated three times. These sequences are also characteristically separated by an 11 bp interval sequence. Among these units, one type (5′-CCCCCCCATCCCCG-3′) has been found to be involved in the transcriptional regulation of TEIF. At the same time, PTB1 (polypyrimidine tract-binding protein 1) has been shown to repress TEIF expression through interaction with this element. Up-regulation of TEIF may be achieved by PTB1 suppression that is induced by DNA damage, or by an olignucleotide decoy, which mediates reversal of suppression. This study provides new insight into the mechanism through which TEIF is involved in DNA damage response, together with insight into the role of polypyrimidine tracts in transcription regulation.

语种英语
所属项目编号30570691 ; 20040001147
资助者National Natural Science Foundation of China ; Doctors Program of Chinese Education Ministry ; National Natural Science Foundation of China ; Doctors Program of Chinese Education Ministry
WOS记录号WOS:000266385400009
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50891
专题基础医学院_病理学系
作者单位Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Sun, Ying,Sun, Qian,McNutt, Michael A.,et al. A cluster of polypyrimidine tracts is involved in the transcription regulation of telomerase transcriptional elements-interacting factor[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2009,327(1-2):65-73.
APA Sun, Ying.,Sun, Qian.,McNutt, Michael A..,Gong, Yilei.,Wang, Jiaochen.,...&Zhang, Bo.(2009).A cluster of polypyrimidine tracts is involved in the transcription regulation of telomerase transcriptional elements-interacting factor.MOLECULAR AND CELLULAR BIOCHEMISTRY,327(1-2),65-73.
MLA Sun, Ying,et al."A cluster of polypyrimidine tracts is involved in the transcription regulation of telomerase transcriptional elements-interacting factor".MOLECULAR AND CELLULAR BIOCHEMISTRY 327.1-2(2009):65-73.
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