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学科主题临床医学
Association Between the XRCC1 Arg399Gln Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis Based on Case-Control Studies
Liu, Chuan1; Yin, Qinghua2; Jiao, Guangjun3; Zhou, Xue4; Ying, Mingzhen1; Gao, Wei1; Hu, Jiangbing2; Wei, Li5; Wang, Ning1; Wang, Yajie1
刊名DNA AND CELL BIOLOGY
2014-06-01
DOI10.1089/dna.2013.2269
33期:6页:378-387
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Genetics & Heredity
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; DNA-REPAIR GENES ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; POLISH POPULATION ; ORAL-CANCER ; RISK ; XPD ; FREQUENCY ; SMOKING ; STATISTICS
英文摘要

Published data regarding the association between the XRCC1 Arg399Gln polymorphism and head and neck cancer (HNC) susceptibility showed inconsistent results. This meta-analysis of eligible literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science with a time limit of Oct 28, 2013. Summary odds ratios (ORs) with 95% CIs were used to assess the strength of association between XRCC1 Arg399Gln polymorphism and HNC susceptibility using random-effect model. A total of 27 case-control studies including 5942 cases and 9041 controls were included for analysis. Meta-analysis of total studies showed that the XRCC1 Arg399Gln variant carriers were not susceptible to HNC (AA vs. GG: OR = 0.92, 95% CI = 0.77-1.11; AG vs. GG: OR = 1.05, 95% CI = 0.76-1.44; the dominant model AA + AG vs. GG: OR = 1.00, 95% CI = 0.78-1.29; the recessive model AA vs. AG + GG: OR = 0.91, 95% CI = 0.71-1.16). Further, subgroup analyses by ethnicity and source of controls did not identify any significant associations of XRCC1 Arg399Gln polymorphism with head and neck susceptibility in any populations. Our meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was not a risk factor for HNC susceptibility.

语种英语
WOS记录号WOS:000337166900006
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50893
专题北京大学第二临床医学院_骨肿瘤科
作者单位1.First Peoples Hosp Yueyang, Dept Oncol, Yueyang, Peoples R China
2.401 Hosp PLA, Dept Oncol, Qingdao, Peoples R China
3.Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai 200433, Peoples R China
4.Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100871, Peoples R China
5.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 1, Dept Gynecol & Obstet, Shanghai 200030, Peoples R China
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Liu, Chuan,Yin, Qinghua,Jiao, Guangjun,et al. Association Between the XRCC1 Arg399Gln Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis Based on Case-Control Studies[J]. DNA AND CELL BIOLOGY,2014,33(6):378-387.
APA Liu, Chuan.,Yin, Qinghua.,Jiao, Guangjun.,Zhou, Xue.,Ying, Mingzhen.,...&Wang, Yajie.(2014).Association Between the XRCC1 Arg399Gln Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis Based on Case-Control Studies.DNA AND CELL BIOLOGY,33(6),378-387.
MLA Liu, Chuan,et al."Association Between the XRCC1 Arg399Gln Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis Based on Case-Control Studies".DNA AND CELL BIOLOGY 33.6(2014):378-387.
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