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学科主题基础医学
Hepatitis E virus seroprevalence and molecular study among blood donors in China
Ren, Furong1; Zhao, Chenyan2,3; Wang, Ling4,5; Wang, Zhuoyan1; Gong, Xiaoyan1; Song, Meilan1; Zhuang, Hui4,5; Huang, Yi6; Shan, Hua7; Wang, Jingxing6; Liu, Qiang2; Ness, Paul7; Nelson, Kenrad E.8; Wang, Youchun2
刊名TRANSFUSION
2014-03-01
DOI10.1111/trf.12530
54期:3页:910-917
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
资助者Novartis ; Novartis
研究领域[WOS]Hematology
关键词[WOS]ELEVATED ALANINE AMINOTRANSFERASE ; IGG SEROPREVALENCE ; NATIONWIDE SURVEY ; PREVALENCE ; INFECTION ; ANTIBODIES ; JAPAN ; HEV ; DIVERSITY ; DIAGNOSIS
英文摘要

BACKGROUND: The risk of hepatitis E virus (HEV) infection from blood transfusion has aroused increasing concern in many countries. The aim of this study was to analyze the potential risk of HEV infection through blood transfusion in China.

STUDY DESIGN AND METHODS: Qualified blood donations and donations with isolated alanine aminotransferase (ALT) elevations from five geographically diverse Chinese regions were tested for anti-HEV immunoglobulin (Ig)M and IgG and HEV antigen. The positive samples for anti-HEV IgM and HEV antigen were tested for HEV RNA. HEV open reading frame (ORF)2 partial sequences were analyzed from HEV RNA-positive samples.

RESULTS: The seroprevalence rates of HEV antigen and anti-HEV IgM and IgG among qualified donations were 0.06% (6/10,741), 1.02% (109/10,741), and 27.42% (2945/10,741), respectively. Samples with isolated ALT elevations had higher prevalence of HEV markers, namely, HEV antigen of 0.25% (2/797), anti-HEV IgM of 2.76% (22/797), and anti-HEV IgG of 40.02% (319/797). The HEV antibody prevalence varied significantly by age, sex, and geographic region. All 131 samples that were anti-HEV IgM positive were negative for HEV RNA, whereas four of eight (50%) samples positive for HEV antigen were HEV RNA positive. HEV ORF2 sequences from three of four HEV RNA-positive samples were determined and grouped with Genotype 4.

CONCLUSION: Qualified donations after routine blood donor screening still carry potential risk for transmitting HEV. HEV antigen screening could be one measure to reduce the risk of HEV transmission by blood transfusion.

语种英语
资助者Novartis ; Novartis
WOS记录号WOS:000340188500023
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50901
专题基础医学院_病原生物学系
作者单位1.Beijing Red Cross Blood Ctr, Beijing, Peoples R China
2.Jilin Univ, Coll Life Sci, Changchun 130023, Peoples R China
3.Minist Hlth Res Qual & Standardizat Biotech Prod, Div HIV & Sexual Transmitted Virus Vaccine, Natl Inst Food & Drug Control, Key Lab, Beijing 100050, Peoples R China
4.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
5.Peking Univ, Ctr Infect Dis, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
6.Chinese Acad Med Sci, Inst Blood Transfus, Chengdu, Peoples R China
7.Johns Hopkins Med Inst, Dept Pathol, Div Blood Transfus, HIV Specialty Testing Lab, Baltimore, MD 21205 USA
8.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
推荐引用方式
GB/T 7714
Ren, Furong,Zhao, Chenyan,Wang, Ling,et al. Hepatitis E virus seroprevalence and molecular study among blood donors in China[J]. TRANSFUSION,2014,54(3):910-917.
APA Ren, Furong.,Zhao, Chenyan.,Wang, Ling.,Wang, Zhuoyan.,Gong, Xiaoyan.,...&Wang, Youchun.(2014).Hepatitis E virus seroprevalence and molecular study among blood donors in China.TRANSFUSION,54(3),910-917.
MLA Ren, Furong,et al."Hepatitis E virus seroprevalence and molecular study among blood donors in China".TRANSFUSION 54.3(2014):910-917.
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