IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Hepatitis E virus seroprevalence and molecular study among blood donors in China
Ren, Furong1; Zhao, Chenyan2,3; Wang, Ling4,5; Wang, Zhuoyan1; Gong, Xiaoyan1; Song, Meilan1; Zhuang, Hui4,5; Huang, Yi6; Shan, Hua7; Wang, Jingxing6; Liu, Qiang2; Ness, Paul7; Nelson, Kenrad E.8; Wang, Youchun2
刊名TRANSFUSION
2014-03-01
DOI10.1111/trf.12530
54期:3页:910-917
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]ELEVATED ALANINE AMINOTRANSFERASE ; IGG SEROPREVALENCE ; NATIONWIDE SURVEY ; PREVALENCE ; INFECTION ; ANTIBODIES ; JAPAN ; HEV ; DIVERSITY ; DIAGNOSIS
英文摘要

BACKGROUND: The risk of hepatitis E virus (HEV) infection from blood transfusion has aroused increasing concern in many countries. The aim of this study was to analyze the potential risk of HEV infection through blood transfusion in China.

STUDY DESIGN AND METHODS: Qualified blood donations and donations with isolated alanine aminotransferase (ALT) elevations from five geographically diverse Chinese regions were tested for anti-HEV immunoglobulin (Ig)M and IgG and HEV antigen. The positive samples for anti-HEV IgM and HEV antigen were tested for HEV RNA. HEV open reading frame (ORF)2 partial sequences were analyzed from HEV RNA-positive samples.

RESULTS: The seroprevalence rates of HEV antigen and anti-HEV IgM and IgG among qualified donations were 0.06% (6/10,741), 1.02% (109/10,741), and 27.42% (2945/10,741), respectively. Samples with isolated ALT elevations had higher prevalence of HEV markers, namely, HEV antigen of 0.25% (2/797), anti-HEV IgM of 2.76% (22/797), and anti-HEV IgG of 40.02% (319/797). The HEV antibody prevalence varied significantly by age, sex, and geographic region. All 131 samples that were anti-HEV IgM positive were negative for HEV RNA, whereas four of eight (50%) samples positive for HEV antigen were HEV RNA positive. HEV ORF2 sequences from three of four HEV RNA-positive samples were determined and grouped with Genotype 4.

CONCLUSION: Qualified donations after routine blood donor screening still carry potential risk for transmitting HEV. HEV antigen screening could be one measure to reduce the risk of HEV transmission by blood transfusion.

语种英语
WOS记录号WOS:000340188500023
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50901
Collection北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Beijing Red Cross Blood Ctr, Beijing, Peoples R China
2.Jilin Univ, Coll Life Sci, Changchun 130023, Peoples R China
3.Minist Hlth Res Qual & Standardizat Biotech Prod, Div HIV & Sexual Transmitted Virus Vaccine, Natl Inst Food & Drug Control, Key Lab, Beijing 100050, Peoples R China
4.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
5.Peking Univ, Ctr Infect Dis, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
6.Chinese Acad Med Sci, Inst Blood Transfus, Chengdu, Peoples R China
7.Johns Hopkins Med Inst, Dept Pathol, Div Blood Transfus, HIV Specialty Testing Lab, Baltimore, MD 21205 USA
8.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
Recommended Citation
GB/T 7714
Ren, Furong,Zhao, Chenyan,Wang, Ling,et al. Hepatitis E virus seroprevalence and molecular study among blood donors in China[J]. TRANSFUSION,2014,54(3):910-917.
APA Ren, Furong.,Zhao, Chenyan.,Wang, Ling.,Wang, Zhuoyan.,Gong, Xiaoyan.,...&Wang, Youchun.(2014).Hepatitis E virus seroprevalence and molecular study among blood donors in China.TRANSFUSION,54(3),910-917.
MLA Ren, Furong,et al."Hepatitis E virus seroprevalence and molecular study among blood donors in China".TRANSFUSION 54.3(2014):910-917.
Files in This Item: Download All
File Name/Size DocType Version Access License
Hepatitis E virus se(136KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Ren, Furong]'s Articles
[Zhao, Chenyan]'s Articles
[Wang, Ling]'s Articles
百度学术
百度学术Similar articles in
[Ren, Furong]'s Articles
[Zhao, Chenyan]'s Articles
[Wang, Ling]'s Articles
必应学术
必应学术Similar articles in
[Ren, Furong]'s Articles
[Zhao, Chenyan]'s Articles
[Wang, Ling]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Hepatitis E virus seroprevalence and molecular study among blood donors in China.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.