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学科主题: 基础医学
题名:
Hepatitis E virus seroprevalence and molecular study among blood donors in China
作者: Ren, Furong1; Zhao, Chenyan2,3; Wang, Ling4,5; Wang, Zhuoyan1; Gong, Xiaoyan1; Song, Meilan1; Zhuang, Hui4,5; Huang, Yi6; Shan, Hua7; Wang, Jingxing6; Liu, Qiang2; Ness, Paul7; Nelson, Kenrad E.8; Wang, Youchun2
刊名: TRANSFUSION
发表日期: 2014-03-01
DOI: 10.1111/trf.12530
卷: 54, 期:3, 页:910-917
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: ELEVATED ALANINE AMINOTRANSFERASE ; IGG SEROPREVALENCE ; NATIONWIDE SURVEY ; PREVALENCE ; INFECTION ; ANTIBODIES ; JAPAN ; HEV ; DIVERSITY ; DIAGNOSIS
英文摘要:

BACKGROUND: The risk of hepatitis E virus (HEV) infection from blood transfusion has aroused increasing concern in many countries. The aim of this study was to analyze the potential risk of HEV infection through blood transfusion in China.

STUDY DESIGN AND METHODS: Qualified blood donations and donations with isolated alanine aminotransferase (ALT) elevations from five geographically diverse Chinese regions were tested for anti-HEV immunoglobulin (Ig)M and IgG and HEV antigen. The positive samples for anti-HEV IgM and HEV antigen were tested for HEV RNA. HEV open reading frame (ORF)2 partial sequences were analyzed from HEV RNA-positive samples.

RESULTS: The seroprevalence rates of HEV antigen and anti-HEV IgM and IgG among qualified donations were 0.06% (6/10,741), 1.02% (109/10,741), and 27.42% (2945/10,741), respectively. Samples with isolated ALT elevations had higher prevalence of HEV markers, namely, HEV antigen of 0.25% (2/797), anti-HEV IgM of 2.76% (22/797), and anti-HEV IgG of 40.02% (319/797). The HEV antibody prevalence varied significantly by age, sex, and geographic region. All 131 samples that were anti-HEV IgM positive were negative for HEV RNA, whereas four of eight (50%) samples positive for HEV antigen were HEV RNA positive. HEV ORF2 sequences from three of four HEV RNA-positive samples were determined and grouped with Genotype 4.

CONCLUSION: Qualified donations after routine blood donor screening still carry potential risk for transmitting HEV. HEV antigen screening could be one measure to reduce the risk of HEV transmission by blood transfusion.

语种: 英语
项目资助者: Novartis
WOS记录号: WOS:000340188500023
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50901
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Beijing Red Cross Blood Ctr, Beijing, Peoples R China
2.Jilin Univ, Coll Life Sci, Changchun 130023, Peoples R China
3.Minist Hlth Res Qual & Standardizat Biotech Prod, Div HIV & Sexual Transmitted Virus Vaccine, Natl Inst Food & Drug Control, Key Lab, Beijing 100050, Peoples R China
4.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
5.Peking Univ, Ctr Infect Dis, Hlth Sci Ctr, Sch Basic Med Sci, Beijing 100871, Peoples R China
6.Chinese Acad Med Sci, Inst Blood Transfus, Chengdu, Peoples R China
7.Johns Hopkins Med Inst, Dept Pathol, Div Blood Transfus, HIV Specialty Testing Lab, Baltimore, MD 21205 USA
8.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

Recommended Citation:
Ren, Furong,Zhao, Chenyan,Wang, Ling,et al. Hepatitis E virus seroprevalence and molecular study among blood donors in China[J]. TRANSFUSION,2014,54(3):910-917.
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