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学科主题: 临床医学
题名:
Proteomic research of high-glucose-activated endothelial microparticles and related proteins to Alzheimer′s disease
作者: Zu, Lingyun1; Niu, Chenguang2,3,4; Li, Jizhao2,3,4; Shan, Liyang5,6; Li, Ling7; Zhang, Dongmei7; Willard, Belinda7; Zheng, Lemin2,3,4
关键词: Alzheimer&prime ; s disease ; diabetes ; endothelial microparticles ; high glucoses ; proteome
刊名: DIABETES & VASCULAR DISEASE RESEARCH
发表日期: 2015-11-01
DOI: 10.1177/1479164115597865
卷: 12, 期:6, 页:467-470
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Peripheral Vascular Disease
研究领域[WOS]: Endocrinology & Metabolism ; Cardiovascular System & Cardiology
关键词[WOS]: DIABETES-MELLITUS ; OXIDATIVE STRESS ; PLATELETS ; PATTERNS
英文摘要:

The study was designed to discover the biological function of endotheliocyte-derived microparticles in diabetes condition. A quantitative shotgun proteomics methodology was performed to study the proteome of these high-glucose-activated endothelial microparticles. A total of 1428 proteins were identified, containing 1421 and 1423 proteins in control and high-glucose groups, respectively. According to the ExoCarta database, 669 proteins have previously been identified in microparticles. The proteins associated with disease were identified in this study, and notably, 30 proteins have been reported to be associated with Alzheimer′s disease, including amyloid beta A4 protein. Besides, the peptide abundance of amyloid beta A4 protein from control group was much less than that from high-glucose group. In conclusion, this work revealed the proteome of endothelial microparticles in mimic diabetes condition and provided a new proteomic evidence for Alzheimer′s disease to be counted as the type 3 diabetes.

语种: 英语
所属项目编号: 2011CB503900 ; 81170101 ; 81370235 ; 81300076 ; 7122106 ; 7132195 ; 1S10RR031537-01
项目资助者: &prime ; 973&prime ; National ST Major Project ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing, China ; NIH S10 grant from the United States
WOS记录号: WOS:000363460600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50902
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Inst Syst Biomed, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
4.Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Nanjing Med Univ, Key Lab Cardiovasc Dis & Mol Intervent, Nanjing, Jiangsu, Peoples R China
6.Nanjing Med Univ, Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China
7.Cleveland Clin, Lerner Res Inst Prote Lab, Cleveland, OH 44106 USA

Recommended Citation:
Zu, Lingyun,Niu, Chenguang,Li, Jizhao,et al. Proteomic research of high-glucose-activated endothelial microparticles and related proteins to Alzheimer′s disease[J]. DIABETES & VASCULAR DISEASE RESEARCH,2015,12(6):467-470.
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