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学科主题: 口腔医学
题名:
BMP-SHH Signaling Network Controls Epithelial Stem Cell Fate via Regulation of Its Niche in the Developing Tooth
作者: Li, Jingyuan1,2; Feng, Jifan1; Liu, Yang1,3; Thach-Vu Ho1; Grimes, Weston1; Hoang Anh Ho1; Park, Shery1; Wang, Songlin2; Chai, Yang1
刊名: DEVELOPMENTAL CELL
发表日期: 2015-04-20
DOI: 10.1016/j.devcel.2015.02.021
卷: 33, 期:2, 页:125-135
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Developmental Biology
研究领域[WOS]: Cell Biology ; Developmental Biology
关键词[WOS]: ROOT DEVELOPMENT ; HAIR-FOLLICLES ; MOUSE INCISOR ; SELF-RENEWAL ; SKIN ; GROWTH ; MICE ; DIFFERENTIATION ; PROLIFERATION ; REGENERATION
英文摘要:

During embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal organs, such as teeth, hair follicles, mammary glands, and salivary glands. Interestingly, these ectodermal organs differ in their tissue homeostasis, which leads to differential abilities for continuous growth postnatally. Mouse molars lose the ability to grow continuously, whereas incisors retain this ability. In this study, we found that a BMP-Smad4-SHH-Gli1 signaling network may provide a niche supporting transient Sox2+ dental epithelial stem cells in mouse molars. This mechanism also plays a role in continuously growing mouse incisors. The differential fate of epithelial stem cells in mouse molars and incisors is controlled by this BMP/SHH signaling network, which partially accounts for the different postnatal growth potential of molars and incisors. Collectively, our study highlights the importance of crosstalk between two signaling pathways, BMP and SHH, in regulating the fate of epithelial stem cells during organogenesis.

语种: 英语
所属项目编号: R01 DE022503
项目资助者: National Institute of Dental and Craniofacial Research (NIDCR), NIH
WOS记录号: WOS:000353352300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50904
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Univ So Calif, Ctr Craniofacial Mol Biol, Ostrow Sch Dent, Los Angeles, CA 90033 USA
2.Capital Med Univ Sch Stomatol, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Mol Lab Gene Therapy & Tooth Regenerat, Beijing 100050, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China

Recommended Citation:
Li, Jingyuan,Feng, Jifan,Liu, Yang,et al. BMP-SHH Signaling Network Controls Epithelial Stem Cell Fate via Regulation of Its Niche in the Developing Tooth[J]. DEVELOPMENTAL CELL,2015,33(2):125-135.
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