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学科主题: 基础医学
题名:
QiShenYiQi Pills (R) prevents cardiac ischemia-reperfusion injury via energy modulation
作者: Lin, Se-Qi1,2,3; Wei, Xiao-Hong3; Huang, Ping3; Liu, Yu-Ying3; Zhao, Na3; Li, Quan3; Pan, Chun-Shui3; Hu, Bai-He3; Chang, Xin3; Fan, Jing-Yu3; Yang, Xiao-Yuan3,4; Wang, Chaun-She3,4; Liu, Hong-Ning1; Han, Jing-Yan3,4
关键词: Cardiac function ; Salvia miltiorrhiza ; Mongolian milkvetch root ; ATP synthase subunit ; Cardiac injury
刊名: INTERNATIONAL JOURNAL OF CARDIOLOGY
发表日期: 2013-09-30
DOI: 10.1016/j.ijcard.2012.10.042
卷: 168, 期:2, 页:967-974
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: MYOCARDIAL-ISCHEMIA ; PROTECTS
英文摘要:

Background: QiShenYiQi Pills (R) (QSYQ) is a compound Chinese medicine used in China for alleviating cardiac function. The present study was designed to explore the effect and mechanism of QSYQ on ischemia-reperfusion (I/R)-induced disorders in myocardial structure and function, with particularly focusing on the regulation of energy metabolism.

Methods: Sprague-Dawley rats, with or without QSYQ pretreatment, were subjected to 30 min occlusion of the left anterior descending coronary artery and followed by 90 min or 24 h reperfusion. Myocardial blood flow (MBF) and cardiac function were evaluated at baseline, immediately after ischemia and 30, 60, 90 min, and 24 h after reperfusion. Myocardial infarction, myocardial histology and ultrastructure were assessed. Double staining of alpha-cardiac actinin and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling was conducted to assess myocardial apoptosis. ATP, ADP and AMP content was determined by Enzyme-Linked Immunosorbent Assay, F-actin in myocardial cells determined by immunofluorescence microscopy and expression of ATP synthase alpha, ATP5D, and phosphorylated-Myosin Light Chain (P-MLC) determined by western blotting.

Results: Pre-treatment with QSYQ protected against I/R-induced MBF decrease, myocardial infarction and apoptosis at 90 min and 24 h after reperfusion. Moreover, I/R 90 min caused an impairment on cardiac function, a decrease in the ratio of ADP/ATP and AMP/ATP, accompanying with reduction of ATP 5D expression and increase in the expression of P-MLC, meanwhile, myocardium to exhibit myocardial fiber rupture, interstitial edema, and mitochondria swelling, all of which were significantly ameliorated by pre-treatment with QSYQ.

Conclusions: The results of the present study suggest an involvement of regulation of energy metabolism in the action of QSYQ to protect against myocardial I/R injury. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2008ZX09401 ; 81273637
项目资助者: Production of New Medicine Program of Ministry of Science and Technology of the People&prime ; s Republic of China ; National Natural Science Foundation of China
WOS记录号: WOS:000325412800072
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50905
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Hunan Univ Chinese Med, Grad Sch, Changsha, Hunan, Peoples R China
2.Jiangxi Univ TCM, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Jiangxi, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100871, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Integrat Tradit Chinese & Western Med, Beijing 100871, Peoples R China

Recommended Citation:
Lin, Se-Qi,Wei, Xiao-Hong,Huang, Ping,et al. QiShenYiQi Pills (R) prevents cardiac ischemia-reperfusion injury via energy modulation[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY,2013,168(2):967-974.
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