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学科主题临床医学
MAPKAP1 rs10118570 Polymorphism Is Associated with Anti-Infection and Anti-Hepatic Fibrogenesis in Schistosomiasis Japonica
Zhu, Xiao1,2; Zhang, Jinfang3; Fan, Wenguo4; Gong, Yunguo5; Yan, Jianhua6; Yuan, Zhidong7; Wu, Lang8; Cui, Hongjing1; Luo, Haiqing1; Kong, Qingming9; Tang, Li10; Leng, Shuilong11; Liao, Yufeng12; Fu, Weiming3,13; Xiao, Qin2; Li, Dongpei1,14
刊名PLOS ONE
2014-08-25
DOI10.1371/journal.pone.0105995
9期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CELL LUNG-CANCER ; HEPATOCELLULAR-CARCINOMA ; CHROMOSOMAL INSTABILITY ; 3&prime ; UTR ; GRP78 ; CHINA ; INFECTION ; RISK ; SUSCEPTIBILITY ; INFLAMMATION
英文摘要

Chronic infection with Schistosoma japonicum is an important cause of hepatic fibrosis (HF). Human 9q33.3 is one of the most important loci for stress-related diseases. We examined the potential associations of 43 single-nucleotide polymorphisms (SNPs) with S. japonicum infection and HF in epidemic region in China. We identified a SNP (rs10118570 GG in mitogen-activated protein kinase associated protein 1, MAPKAP1) contributes to anti-infection (adjusted OR = 0.35) and anti-fibrogenesis (adjusted RR = 0.44) in the discovery study. Replicative and combined studies showed consistent protective quality for this genotype (replicative: adjusted OR = 0.37 for anti-infection, and adjusted RR = 0.40 for anti-fibrogenesis; Combined: adjusted OR = 0.45 for anti-infection, and adjusted RR = 0.42 for anti-fibrogenesis). Univariate and multivariate analysis in the discovery, replicative and combined studies, suggested that durations (years), splenomegaly, serum ALB and rs10118570 were independent predictors influencing the fibrogenesis. The analysis of gene-gene interaction showed rs10118570 functions independently. We conclude that MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica. And rs10118570 may be a potential biomarker and target for the treatment of this life-threatening ancient disease.

语种英语
WOS记录号WOS:000340952200102
项目编号81071697 ; 31100914 ; 30700436 ; 81271166 ; 81201831 ; S2011040003694 ; 2012J4100075 ; 12C22061657 ; XB1382 ; GZ1131-B
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Research Project of Science and Information Technology of Guangzhou City Grant ; Research Project of Initial for Talent Research in Guangdong Medical College
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50909
专题北京大学深圳医院
作者单位1.Hunan Univ Sci & Technol, Sch Life Sci, Xiangtan, Peoples R China
2.Mayo Clin, Ctr Clin & Translat Sci, Rochester, MN USA
3.Ningbo 2 Hosp, Dept Lab Med, Ningbo, Zhejiang, Peoples R China
4.A STAR NUS, Clin Imaging Res Ctr, Singapore, Singapore
5.Guangdong Med Coll, Dept Clin Oncol, Guangdong Prov Key Lab Med Mol Diag, Zhanjiang Dongguan, Peoples R China
6.Peking Univ, Shenzhen Hosp, Shenzhen Peking Univ, Hong Kong Univ Sci & Technol,Med Ctr, Shenzhen, Peoples R China
7.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China
8.Sun Yat Sen Univ, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510275, Guangdong, Peoples R China
9.Univ Texas Houston, Sch Biomed Informat, Houston, TX USA
10.Zhejiang Acad Med Sci, Immun & Biochem Res Lab, Hangzhou, Zhejiang, Peoples R China
11.Hubei Acad Prevent Med, Hubei Prov Ctr Dis Control & Prevent, Schistosomiasis Inst, Wuhan, Peoples R China
12.Guangzhou Med Univ, Dept Human Anat, Guangzhou, Guangdong, Peoples R China
13.Chinese Acad Sci, Guangzhou Inst Adv Technol, Guangzhou, Guangdong, Peoples R China
14.Georgia Regents Univ, Dept Neurosci & Regenerat Med, Inst Mol Med & Genet, Augusta, GA USA
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GB/T 7714
Zhu, Xiao,Zhang, Jinfang,Fan, Wenguo,et al. MAPKAP1 rs10118570 Polymorphism Is Associated with Anti-Infection and Anti-Hepatic Fibrogenesis in Schistosomiasis Japonica[J]. PLOS ONE,2014,9(8).
APA Zhu, Xiao.,Zhang, Jinfang.,Fan, Wenguo.,Gong, Yunguo.,Yan, Jianhua.,...&Li, Dongpei.(2014).MAPKAP1 rs10118570 Polymorphism Is Associated with Anti-Infection and Anti-Hepatic Fibrogenesis in Schistosomiasis Japonica.PLOS ONE,9(8).
MLA Zhu, Xiao,et al."MAPKAP1 rs10118570 Polymorphism Is Associated with Anti-Infection and Anti-Hepatic Fibrogenesis in Schistosomiasis Japonica".PLOS ONE 9.8(2014).
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