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Long-term outcomes of unmanipulated haploidentical HSCT for paediatric patients with acute leukaemia
Liu, D-H; Xu, L-P; Liu, K-Y; Wang, Y.; Chen, H.; Han, W.; Zhang, X-H; Yan, C-H; Zhang, Y-Y; Wang, J-Z; Chen, Y-H; Wang, F-R; Huang, X-J
关键词Transplantation Haploidentical Paediatric Acute Leukaemia
刊名BONE MARROW TRANSPLANTATION
2013-11-01
DOI10.1038/bmt.2013.99
48期:12页:1519-1524
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]STEM-CELL TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; RISK ACUTE-LEUKEMIA ; CHILDREN ; MALIGNANCIES ; RELAPSE ; IMPACT
英文摘要

Allogeneic hematopoietic SCT is indicated for children whose disease demonstrates dismal prognosis with chemotherapy. This study aims to analyse the most recent outcomes of unmanipulated haploidentical (HID) HSCT for paediatric patients with acute leukaemia. Those from matched sibling donors (MSD) HSCT provided a parallel cohort to illustrate the benefits of HID. Conditioning regimen was modified BuCy2. Anti-thymoglobulin was used for HID. Mobilised marrow and blood stem cells were used as the grafts. All patients in HID achieved neutrophil recovery and 96.7% platelet recovery. In HID, the incidences of acute GVHD 3-4 and extensive chronic GVHD were 14.3 and 26.6%. Play-performance score 90-100% was recorded in 79.7% of all survivors. The 5-year leukaemia-free survival (LFS) in CR1, CR2, beyond CR2 or non-remission were 68.9%, 56.6%, 22.2% and 82.5%, 59.4%, 42.9% for ALL and AML, respectively. In MSD group, LFS for ALL and AML in CR1 were 62.5 and 71.7%. Outcomes of the HID HSCT for paediatric patients with acute leukaemia showed benefits that were similar to those of the parallel cohort of MSD HSCT.

语种英语
WOS记录号WOS:000328051000006
项目编号30971292 ; 2008BAI61B01
资助机构National Natural Science Foundation of China ; National Clinical Priority Specialty of Ministry of Health of China ; National Science &amp ; Technology Pillar Program
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50917
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Dept Bone Marrow Transplantat, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Liu, D-H,Xu, L-P,Liu, K-Y,et al. Long-term outcomes of unmanipulated haploidentical HSCT for paediatric patients with acute leukaemia[J]. BONE MARROW TRANSPLANTATION,2013,48(12):1519-1524.
APA Liu, D-H.,Xu, L-P.,Liu, K-Y.,Wang, Y..,Chen, H..,...&Huang, X-J.(2013).Long-term outcomes of unmanipulated haploidentical HSCT for paediatric patients with acute leukaemia.BONE MARROW TRANSPLANTATION,48(12),1519-1524.
MLA Liu, D-H,et al."Long-term outcomes of unmanipulated haploidentical HSCT for paediatric patients with acute leukaemia".BONE MARROW TRANSPLANTATION 48.12(2013):1519-1524.
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