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学科主题: 临床医学
题名:
Long-term outcomes of unmanipulated haploidentical HSCT for paediatric patients with acute leukaemia
作者: Liu, D-H; Xu, L-P; Liu, K-Y; Wang, Y.; Chen, H.; Han, W.; Zhang, X-H; Yan, C-H; Zhang, Y-Y; Wang, J-Z; Chen, Y-H; Wang, F-R; Huang, X-J
关键词: transplantation ; haploidentical ; paediatric ; acute leukaemia
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2013-11-01
DOI: 10.1038/bmt.2013.99
卷: 48, 期:12, 页:1519-1524
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: STEM-CELL TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; RISK ACUTE-LEUKEMIA ; CHILDREN ; MALIGNANCIES ; RELAPSE ; IMPACT
英文摘要:

Allogeneic hematopoietic SCT is indicated for children whose disease demonstrates dismal prognosis with chemotherapy. This study aims to analyse the most recent outcomes of unmanipulated haploidentical (HID) HSCT for paediatric patients with acute leukaemia. Those from matched sibling donors (MSD) HSCT provided a parallel cohort to illustrate the benefits of HID. Conditioning regimen was modified BuCy2. Anti-thymoglobulin was used for HID. Mobilised marrow and blood stem cells were used as the grafts. All patients in HID achieved neutrophil recovery and 96.7% platelet recovery. In HID, the incidences of acute GVHD 3-4 and extensive chronic GVHD were 14.3 and 26.6%. Play-performance score 90-100% was recorded in 79.7% of all survivors. The 5-year leukaemia-free survival (LFS) in CR1, CR2, beyond CR2 or non-remission were 68.9%, 56.6%, 22.2% and 82.5%, 59.4%, 42.9% for ALL and AML, respectively. In MSD group, LFS for ALL and AML in CR1 were 62.5 and 71.7%. Outcomes of the HID HSCT for paediatric patients with acute leukaemia showed benefits that were similar to those of the parallel cohort of MSD HSCT.

语种: 英语
所属项目编号: 30971292 ; 2008BAI61B01
项目资助者: National Natural Science Foundation of China ; National Clinical Priority Specialty of Ministry of Health of China ; National Science &amp ; Technology Pillar Program
WOS记录号: WOS:000328051000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50917
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Dept Bone Marrow Transplantat, Beijing 100044, Peoples R China

Recommended Citation:
Liu, D-H,Xu, L-P,Liu, K-Y,et al. Long-term outcomes of unmanipulated haploidentical HSCT for paediatric patients with acute leukaemia[J]. BONE MARROW TRANSPLANTATION,2013,48(12):1519-1524.
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