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A-Methylacyl-CoA Racemase (AMACR) and Prostate-Cancer Risk: A Meta-Analysis of 4,385 Participants
Jiang, Ning1; Zhu, Shimiao1; Chen, Jing1; Niu, Yuanjie1; Zhou, Liqun2
刊名PLOS ONE
2013-10-09
DOI10.1371/journal.pone.0074386
8期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]NEEDLE-BIOPSY SPECIMENS ; BASAL-CELL MARKERS ; TISSUE MICROARRAY ; ALPHA ; EXPRESSION ; ADENOCARCINOMA ; DIAGNOSIS ; BIOMARKER ; P504S ; P63
英文摘要

Background: Alpha-methylacyl-CoA racemase (AMACR) is a mitochondrial and peroxisomal enzyme that is overexpressed in prostate cancer. The aim of this study was to confirm and expand the findings that the PCa risk increased in men associated with AMACR expression across various geographic regions.

Methods: A systematic search of databases was carried out and other relevant articles were also identified. Then the meta-analyses were conducted according to the standard guidelines.

Results: A total of 22 studies with 4,385 participants were included on the basis of inclusion criteria. AMACR by IHC was significantly associated with increased diagnosis of PCa (OR = 76.08; 95% CI, 25.53-226.68; P < 0.00001). Subgroup-analysis showed that findings didn′t substantially change when only Caucasians or Asians (OR = 51.23; 95% CI, 19.41-135.24; P < 0.00001) were considered. Expression of AMACR by PCR in relation to PCa risk suggested that AMACR was associated with PCa (OR = 33.60; 95% CI, 4.67-241.77; P < 0.00001). There was also no significant publication bias observed.

Conclusions: Our findings provide further evidences that the expression of AMACR contribute to PCa risk. AMACR protein overexpression was found in prostate cancers, low expression in any of the normal tissues or in benign prostatic tissue. AMACR is potentially an important prostate tumor marker.

语种英语
WOS记录号WOS:000325810900003
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50919
专题北京大学第一临床医学院_泌尿外科
作者单位1.Tianjin Med Univ, Tianjin Inst Urol, Hosp 2, Dept Urol, Tianjin, Peoples R China
2.Peking Univ, Inst Urol, Dept Urol, Peking Univ Hosp 1, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Ning,Zhu, Shimiao,Chen, Jing,et al. A-Methylacyl-CoA Racemase (AMACR) and Prostate-Cancer Risk: A Meta-Analysis of 4,385 Participants[J]. PLOS ONE,2013,8(10).
APA Jiang, Ning,Zhu, Shimiao,Chen, Jing,Niu, Yuanjie,&Zhou, Liqun.(2013).A-Methylacyl-CoA Racemase (AMACR) and Prostate-Cancer Risk: A Meta-Analysis of 4,385 Participants.PLOS ONE,8(10).
MLA Jiang, Ning,et al."A-Methylacyl-CoA Racemase (AMACR) and Prostate-Cancer Risk: A Meta-Analysis of 4,385 Participants".PLOS ONE 8.10(2013).
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