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学科主题临床医学
Intrahepatic biliary injuries associated with radiofrequency ablation of hepatic malignancies
Fu Ying1; Yang Wei1; Wu Jin-yu1; Yan Kun1; Wu Wei1; Xing Bao-cai2; Chen Min-hua1
关键词Hepatic Malignancy Radiofrequency Ablation Biliary Tract Injury Complications
刊名CHINESE MEDICAL JOURNAL
2011-07-05
DOI10.3760/cma.j.issn.0366-6999.2011.13.007
124期:13页:1957-1963
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]LIVER-TUMORS ; HEPATOCELLULAR-CARCINOMA ; COMPLICATIONS ; CANCER ; MODEL
英文摘要

Background Biliary injury after radiofrequency ablation can cause serious consequences including death. However, there are limited data regarding bile duct changes with or without complications associated with radiofrequency ablation of hepatic malignancies. This study aimed to assess the incidence, prognosis and risk factors of intrahepatic biliary injury associated with radiofrequency ablation.

Methods Between June 2001 and January 2009, 638 patients with hepatic malignancies (405 with hepatocellular carcinoma, and 233 with liver metastasis) who had 955 treatment sessions were enrolled in this study. Imaging and laboratory data, the course of treatment, and patient outcomes were reviewed retrospectively. The risk factors of biliary injury and the impact on overall survival of patients were analyzed. The chi-square test, Fisher′s exact test, Kaplan-Meier curves and stepwise Logistic regression model were used for statistical analysis where appropriate.

Results Biliary injury was observed in 17 patients after 17 ablation sessions based on imaging findings. The overall incidence of biliary injury was 1.8% (17/955) with an average onset time of 12 weeks (2-36 weeks). Mild, moderate and severe complications of biliary injury were identified in 9, 6 and 2 cases, respectively. The median survival time after detection of biliary injury was 40 months. There seemed no notable difference in overall survival between patients with and those without biliary injuries. By multivariate analysis, vessel infiltration (P=0.034) and treatment session NI times (P=0.025) were independent risk factors for biliary injury of hepatocellular carcinoma; while tumor located centrally was the only independent risk factor in the metastasis group (P=0.043).

Conclusions The incidence of biliary injury was not frequent (1.8%). Through appropriate treatment, intrahepatic bile duct injuries seemed not affect the patients′ long-term survival. Additionally, risk factors may be helpful for selecting radiofrequency ablation candidates and predicting biliary complications. Chin Med J 2011;124(13):1957-1963

语种英语
WOS记录号WOS:000293491000007
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50920
专题北京大学临床肿瘤学院_超声科
北京大学临床肿瘤学院_肝胆胰外一科
北京大学第三临床医学院_超声影像科
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Ultrasound, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Surg Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Fu Ying,Yang Wei,Wu Jin-yu,et al. Intrahepatic biliary injuries associated with radiofrequency ablation of hepatic malignancies[J]. CHINESE MEDICAL JOURNAL,2011,124(13):1957-1963.
APA Fu Ying.,Yang Wei.,Wu Jin-yu.,Yan Kun.,Wu Wei.,...&Chen Min-hua.(2011).Intrahepatic biliary injuries associated with radiofrequency ablation of hepatic malignancies.CHINESE MEDICAL JOURNAL,124(13),1957-1963.
MLA Fu Ying,et al."Intrahepatic biliary injuries associated with radiofrequency ablation of hepatic malignancies".CHINESE MEDICAL JOURNAL 124.13(2011):1957-1963.
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