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学科主题: 临床医学
题名:
Intrahepatic biliary injuries associated with radiofrequency ablation of hepatic malignancies
作者: Fu Ying1; Yang Wei1; Wu Jin-yu1; Yan Kun1; Wu Wei1; Xing Bao-cai2; Chen Min-hua1
关键词: hepatic malignancy ; radiofrequency ablation ; biliary tract ; injury ; complications
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-07-05
DOI: 10.3760/cma.j.issn.0366-6999.2011.13.007
卷: 124, 期:13, 页:1957-1963
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: LIVER-TUMORS ; HEPATOCELLULAR-CARCINOMA ; COMPLICATIONS ; CANCER ; MODEL
英文摘要:

Background Biliary injury after radiofrequency ablation can cause serious consequences including death. However, there are limited data regarding bile duct changes with or without complications associated with radiofrequency ablation of hepatic malignancies. This study aimed to assess the incidence, prognosis and risk factors of intrahepatic biliary injury associated with radiofrequency ablation.

Methods Between June 2001 and January 2009, 638 patients with hepatic malignancies (405 with hepatocellular carcinoma, and 233 with liver metastasis) who had 955 treatment sessions were enrolled in this study. Imaging and laboratory data, the course of treatment, and patient outcomes were reviewed retrospectively. The risk factors of biliary injury and the impact on overall survival of patients were analyzed. The chi-square test, Fisher′s exact test, Kaplan-Meier curves and stepwise Logistic regression model were used for statistical analysis where appropriate.

Results Biliary injury was observed in 17 patients after 17 ablation sessions based on imaging findings. The overall incidence of biliary injury was 1.8% (17/955) with an average onset time of 12 weeks (2-36 weeks). Mild, moderate and severe complications of biliary injury were identified in 9, 6 and 2 cases, respectively. The median survival time after detection of biliary injury was 40 months. There seemed no notable difference in overall survival between patients with and those without biliary injuries. By multivariate analysis, vessel infiltration (P=0.034) and treatment session NI times (P=0.025) were independent risk factors for biliary injury of hepatocellular carcinoma; while tumor located centrally was the only independent risk factor in the metastasis group (P=0.043).

Conclusions The incidence of biliary injury was not frequent (1.8%). Through appropriate treatment, intrahepatic bile duct injuries seemed not affect the patients′ long-term survival. Additionally, risk factors may be helpful for selecting radiofrequency ablation candidates and predicting biliary complications. Chin Med J 2011;124(13):1957-1963

语种: 英语
所属项目编号: 2007AA02Z4B8
项目资助者: National High Technology Research and Development Program "863 Program" of China
WOS记录号: WOS:000293491000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50920
Appears in Collections:北京大学临床肿瘤学院_超声科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Ultrasound, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Surg Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Fu Ying,Yang Wei,Wu Jin-yu,et al. Intrahepatic biliary injuries associated with radiofrequency ablation of hepatic malignancies[J]. CHINESE MEDICAL JOURNAL,2011,124(13):1957-1963.
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