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Preparation, macrophages targeting delivery and anti-inflammatory study of pentapeptide grafted nanostructured lipid carriers
Zhao, Chunyan1; Fan, Tingting1; Yang, Yang1; Wu, Meilin1; Li, Lian1; Zhou, Zhou1; Jian, Yanlin2; Zhang, Qiang3; Huang, Yuan1
关键词Pentapeptide Nanostructured Lipid Carriers Macrophage Cellular Uptake Carrageenan Induced Air Pouch Inflammation
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2013-06-25
DOI10.1016/j.ijpharm.2013.04.030
450期:1-2页:11-20
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]DRUG-DELIVERY ; NITRIC-OXIDE ; NANOPARTICLES ; INFLAMMATION ; CARRAGEENAN ; SYSTEMS
英文摘要

\ The targeting ability of pentapeptide (Thr-Lys-Pro-Pro-Arg) grafted nanostructured lipid carriers (Pen-NLCs) to macrophages was investigated in both in vitro and in vivo studies. The results showed the improvement of the anti-inflammatory effect by using this drug delivery system. Firstly, a pentapeptide-polyethylene glycol2000-stearate was synthesized and formulated into Pen-NLCs. Non-grafted nanostructured lipid carriers (Bare-NLCs) and Pen-NLCs were 190.0 + 1.0 and 203.0 + 8.5 nm in size, -8.1 +/- 2.1 and 2.3 +/- 1.2 mV in zeta potential respectively. Meanwhile, they had comparable entrapment efficiency and drug loading efficiency. In vitro and in vivo cellular uptake studies showed increased internalization of Pen-NLCs by macrophages when compared to pure drugs and Bare-NLCs. Animal studies in a carrageenan-treated air pouch model were used to further investigate the anti-inflammatory effects of Pen-NLCs. Through intravenous administration, a single dose of DXM loaded Pen-NLCs showed the strongest inhibition of inflammatory indexes of air pouch fluid weight, leukocyte infiltration, granulation tissue weight and nitric oxide concentration in comparison with free drugs and DXM loaded Bare-NLCs. In conclusion, this study demonstrated the potential of Pen-NLCs as promising drug carriers for anti-inflammatory treatments. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000319444300002
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50921
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Sichuan Univ, Key Lab Drug Targeting & Drug Delivery, Minist Educ, West China Sch Pharm, Chengdu 610041, Peoples R China
2.Shenzhen Second Peoples Hosp, Shenzhen 518031, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Zhao, Chunyan,Fan, Tingting,Yang, Yang,et al. Preparation, macrophages targeting delivery and anti-inflammatory study of pentapeptide grafted nanostructured lipid carriers[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,450(1-2):11-20.
APA Zhao, Chunyan.,Fan, Tingting.,Yang, Yang.,Wu, Meilin.,Li, Lian.,...&Huang, Yuan.(2013).Preparation, macrophages targeting delivery and anti-inflammatory study of pentapeptide grafted nanostructured lipid carriers.INTERNATIONAL JOURNAL OF PHARMACEUTICS,450(1-2),11-20.
MLA Zhao, Chunyan,et al."Preparation, macrophages targeting delivery and anti-inflammatory study of pentapeptide grafted nanostructured lipid carriers".INTERNATIONAL JOURNAL OF PHARMACEUTICS 450.1-2(2013):11-20.
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