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学科主题: 药学
题名:
Preparation, macrophages targeting delivery and anti-inflammatory study of pentapeptide grafted nanostructured lipid carriers
作者: Zhao, Chunyan1; Fan, Tingting1; Yang, Yang1; Wu, Meilin1; Li, Lian1; Zhou, Zhou1; Jian, Yanlin2; Zhang, Qiang3; Huang, Yuan1
关键词: Pentapeptide ; Nanostructured lipid carriers ; Macrophage ; Cellular uptake ; Carrageenan induced air pouch ; inflammation
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2013-06-25
DOI: 10.1016/j.ijpharm.2013.04.030
卷: 450, 期:1-2, 页:11-20
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DRUG-DELIVERY ; NITRIC-OXIDE ; NANOPARTICLES ; INFLAMMATION ; CARRAGEENAN ; SYSTEMS
英文摘要:

\ The targeting ability of pentapeptide (Thr-Lys-Pro-Pro-Arg) grafted nanostructured lipid carriers (Pen-NLCs) to macrophages was investigated in both in vitro and in vivo studies. The results showed the improvement of the anti-inflammatory effect by using this drug delivery system. Firstly, a pentapeptide-polyethylene glycol2000-stearate was synthesized and formulated into Pen-NLCs. Non-grafted nanostructured lipid carriers (Bare-NLCs) and Pen-NLCs were 190.0 + 1.0 and 203.0 + 8.5 nm in size, -8.1 +/- 2.1 and 2.3 +/- 1.2 mV in zeta potential respectively. Meanwhile, they had comparable entrapment efficiency and drug loading efficiency. In vitro and in vivo cellular uptake studies showed increased internalization of Pen-NLCs by macrophages when compared to pure drugs and Bare-NLCs. Animal studies in a carrageenan-treated air pouch model were used to further investigate the anti-inflammatory effects of Pen-NLCs. Through intravenous administration, a single dose of DXM loaded Pen-NLCs showed the strongest inhibition of inflammatory indexes of air pouch fluid weight, leukocyte infiltration, granulation tissue weight and nitric oxide concentration in comparison with free drugs and DXM loaded Bare-NLCs. In conclusion, this study demonstrated the potential of Pen-NLCs as promising drug carriers for anti-inflammatory treatments. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009CB903300 ; 201002046
项目资助者: National Basic Research Program of China (973 Program) ; Shenzhen Science and Technology Projects
WOS记录号: WOS:000319444300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50921
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Sichuan Univ, Key Lab Drug Targeting & Drug Delivery, Minist Educ, West China Sch Pharm, Chengdu 610041, Peoples R China
2.Shenzhen Second Peoples Hosp, Shenzhen 518031, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Chunyan,Fan, Tingting,Yang, Yang,et al. Preparation, macrophages targeting delivery and anti-inflammatory study of pentapeptide grafted nanostructured lipid carriers[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,450(1-2):11-20.
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