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学科主题: 临床医学
题名:
Effects of Ibutilide on Inhibiting Heart Rate and Rapidly Terminating Atrial Flutter in Canine
作者: Sun, Jianling1; Li, Xiaoying2; Guo, Jihong3; Liu, Peng3; Zhang, Ping3
关键词: Ibutilide ; Canine ; Electrophysiological character ; Atrial flutter
刊名: CELL BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2011-04-01
DOI: 10.1007/s12013-010-9126-8
卷: 59, 期:3, 页:153-158
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: IONIC MECHANISM ; CONVERSION ; FIBRILLATION ; CHANNEL ; CELLS
英文摘要:

Ibutilide is a newer class-III antiarrhythmic agent approved for clinical use. We sought to investigate its electrophysiological effects in canines and also the underlying mechanism of conversion of atrial flutter (AFL). For this purpose, 15 male mongrel dogs were anesthetized, intubated with tracheal tube, and heart was exposed and connected to electrodes. Electrophysiologic variables were measured with and without ibutilide (10-min infusion-dose: 0.10 mg/kg; 30-min later, maintaining dose: 0.01 mg/min) which included heart rate, conduction of intra- and inter-atrium, conduction ratio of isthmus, and ERP. Ibutilide had a significant inhibitory effect on sinus atrial node, peak response time was 20-30 min, and heart rate returned to the baseline after 2 h. One canine had 5 s sinus pause, and the other had 2:1 atrioventricular conduction post-administration. Atrial, ventricular, and pulmonary vein ERP was significantly prolonged (P < 0.05). No significant differences were observed regarding conduction of intra-atrium, inter-atrium, and isthmus. It was, therefore, concluded that ibutilide had suppressive effect on sinus atrial and atrioventricular nodes. Ibutilide rapidly terminated AFL due to the reentrant wave front′s inability to proceed as the refractory period was protracted and hence caused the whole excitable gap of the reentrant circuit to be affected by refractoriness.

语种: 英语
WOS记录号: WOS:000288388600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50924
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Aviat Ind Cent Hosp, Dept Cardiol, Beijing 100012, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China
3.Peking Univ, Dept Cardiol, Peoples Hosp, Electrophysiol Grp, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Jianling,Li, Xiaoying,Guo, Jihong,et al. Effects of Ibutilide on Inhibiting Heart Rate and Rapidly Terminating Atrial Flutter in Canine[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2011,59(3):153-158.
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