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学科主题: 药物依赖
题名:
Effects of scopolamine and ketamine on reconsolidation of morphine conditioned place preference in rats
作者: Zhai, Haifeng; Wu, Ping; Chen, Suqing; Li, Fangqiong; Liu, Yu; Lu, Lin
关键词: cholinergic transmission ; conditioned place preference ; memory reconsolidation ; N-methyl-D-aspartate receptor ; rat ; relapse
刊名: BEHAVIOURAL PHARMACOLOGY
发表日期: 2008-05-01
卷: 19, 期:3, 页:211-216
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: RECEPTOR ANTAGONIST ; PROTEIN-SYNTHESIS ; INDUCED REINSTATEMENT ; BASOLATERAL AMYGDALA ; NUCLEUS-ACCUMBENS ; MEASURING REWARD ; MEMORY ; INHIBITION ; MICE ; REACTIVATION
英文摘要:

Persistent memory associated with addictive drugs contributes to the relapse of drug abuse. The current study was conducted to examine the effects of scopolamine and ketamine on reconsolidation of morphine-induced conditioned place preference (CPP). In experiment 1, after morphine CPP was acquired, rats were injected with ketamine (60mg/kg, intraperitoneally) and scopolamine (2 mg/kg, intraperitoneally), respectively, after reexposure to an earlier morphine-paired context or in their home cages. The CPP was reassessed 24 and 48 h after reexposure. An additional group of rats received saline following reexposure to the earlier morphine-paired context. In experiment 2, two groups of rats were only given saline during the CPP training and subsequent administration of ketamine or scopolamine during the reexposure. In experiment 1, rats failed to exhibit morphine CPP when ketamine and scopolamine were administered only after reexposure to a morphine-paired context. CPP was not abolished by ketamine or scopolamine administration in the animals′ home cages. Also, the animals receiving only saline injections showed strong morphine CPP 24 h after a short exposure to the morphine-paired context. In experiment 2, ketamine or scopolamine treatment alone did not induce CPP or aversion. Administration of scopolamine and ketamine, after reexposure to a drug-paired context, resulted in the disruption of morphine CPP, suggesting the potential effects of scopolamine and ketamine in disrupting memory associated with environmental cues and addictive drugs.

语种: 英语
WOS记录号: WOS:000256207300005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50932
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Zhai, Haifeng,Wu, Ping,Chen, Suqing,et al. Effects of scopolamine and ketamine on reconsolidation of morphine conditioned place preference in rats[J]. BEHAVIOURAL PHARMACOLOGY,2008,19(3):211-216.
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