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学科主题: 临床医学
题名:
Intense pulsed light, near infrared pulsed light, and fractional laser combination therapy for skin rejuvenation in Asian subjects: a prospective multi-center study in China
作者: Tao, Li1; Wu, Jiaqiang1; Qian, Hui1; Lu, Zhong1; Li, Yuanhong2; Wang, Weizhen3; Zhao, Xiaozhong4; Tu, Ping5; Yin, Rui6; Xiang, Leihong1
关键词: Intense pulsed light ; Near infrared light ; Fractional laser ; Skin rejuvenation
刊名: LASERS IN MEDICAL SCIENCE
发表日期: 2015-09-01
DOI: 10.1007/s10103-015-1792-8
卷: 30, 期:7, 页:1977-1983
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Surgery
研究领域[WOS]: Engineering ; Surgery
关键词[WOS]: BLINDED RESPONSE EVALUATION ; SPLIT-FACE TRIAL ; PHOTODAMAGED SKIN ; FACIAL REJUVENATION ; ERBIUM ; PHOTOTHERMOLYSIS ; RHYTIDS
英文摘要:

Ablative skin rejuvenation therapies have limitations for Asian people, including post-inflammatory hyperpigmentation and long down time. Non-ablative lasers are safer but have limited efficacy. This study is to investigate the safety and efficacy of a combination therapy consisting of intense pulsed light (IPL), near infrared (NIR) light, and fractional erbium YAG (Er:YAG) laser for skin rejuvenation in Asian people. This study recruited 113 subjects from six sites in China. Subjects were randomly assigned to a full-face group, who received combination therapy, and split-face groups, in which one half of the face received combination therapy and the other half received IPL monotherapy. Each subject received five treatment sessions during a period of 90 days. Subjects were followed up at 1 and 3 months post last treatment. Three months after last treatment, the full-face group (n = 57) had a global improvement rate of 29 % and 29 % for wrinkles, 32 % for skin texture, 33 % for pigment spots, 28 % for pore size, respectively. For patients in the split-face groups (n = 54), monotherapy side had a global improvement rate of 23 % and 20 % for wrinkles, 27 % for skin texture, 25 % for pigment spots, 25 % for pore size, respectively. Both combination therapy and monotherapy resulted in significant improvements at the follow-up visits compared to baseline (P < 0.001). Combination therapy showed significantly greater improvements compared to monotherapy at two follow-up visits (P < 0.05). Combination therapy is a safe and more effective strategy than IPL monotherapy for skin rejuvenation in Asian people.

语种: 英语
WOS记录号: WOS:000360863300020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50933
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Air Force Hosp, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
3.Fudan Univ, Huashan Hosp, Shanghai 200433, Peoples R China
4.Chinese Med Univ, Hosp 1, Shenyang, Peoples R China
5.Wuhan 1 Hosp, Wuhan, Hubei Province, Peoples R China
6.Third Mil Med Univ, Xinan Hosp, Chongqing, Peoples R China

Recommended Citation:
Tao, Li,Wu, Jiaqiang,Qian, Hui,et al. Intense pulsed light, near infrared pulsed light, and fractional laser combination therapy for skin rejuvenation in Asian subjects: a prospective multi-center study in China[J]. LASERS IN MEDICAL SCIENCE,2015,30(7):1977-1983.
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