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Quantitative cerebral blood flow mapping and functional connectivity of postherpetic neuralgia pain: A perfusion fMRI study
Liu, Jing1; Hao, Ying2; Du, Minyi3; Wang, Xiaoying1,2; Zhang, Jue2,4; Manor, Brad2,5; Jiang, Xuexiang1; Fang, Wenxue3; Wang, Dongxin3
关键词Arterial Spin Label Cerebral Blood Flow Postherpetic Neuralgia Regional Cbf Seed-based Correlation Analysis Striatum
刊名PAIN
2013
DOI10.1016/j.pain.2012.09.016
154期:1页:110-118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]Anesthesiology ; Neurosciences & Neurology
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; SOMATOSENSORY CORTEX ; BRAIN RESPONSES ; MRI ; STATE ; FIBROMYALGIA ; METAANALYSIS ; STIMULATION ; PERCEPTION ; DYNAMICS
英文摘要

This article investigates the effects of postherpetic neuralgia (PHN) on resting-state brain activity utilizing arterial spin labeling (ASL) techniques. Features of static and dynamic cerebral blood flow (CBF) were analyzed to reflect the specific brain response to PHN pain. Eleven consecutive patients suffering from PHN and 11 age- and gender-matched control subjects underwent perfusion functional magnetic resonance imaging brain scanning during the resting state. Group comparison was conducted to detect the regions with significant changes of CBF in PHN patients. Then we chose those regions that were highly correlated with the self-reported pain intensity as "seeds" to calculate the functional connectivity of both groups. Absolute CBF values of these regions were also compared across PHN patients and control subjects. Significant increases in CBF of the patient group were observed in left striatum, right thalamus, left primary somatosensory cortex (S1), left insula, left amygdala, left primary somatomotor cortex, and left inferior parietal lobule. Significant decreases in CBF were mainly located in the frontal cortex. Regional CBF in the left caudate, left insula, left S1, and right thalamus was highly correlated with the pain intensity, and further comparison showed that the regional CBF in these regions is significantly higher in PHN groups. Functional connectivity results demonstrated that the reward circuitry involved in striatum, prefrontal cortex, amygdala, and parahippocampal gyrus and the circuitry among striatum, thalamus, and insula were highly correlated with each element in PHN patients. In addition, noninvasive brain perfusion imaging at rest may provide novel insights into the central mechanisms underlying PHN pain. (C) 2012 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved.

语种英语
WOS记录号WOS:000312818800018
资助机构Fundamental Research Funds for the Central Universities
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50934
专题北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_麻醉科
北京大学第一临床医学院_医学影像科
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Anesthesiol, Beijing 100871, Peoples R China
5.Harvard Univ, Beth Israel Deaconess Med Ctr, Div Gerontol, Sch Med, Boston, MA 02215 USA
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Liu, Jing,Hao, Ying,Du, Minyi,et al. Quantitative cerebral blood flow mapping and functional connectivity of postherpetic neuralgia pain: A perfusion fMRI study[J]. PAIN,2013,154(1):110-118.
APA Liu, Jing.,Hao, Ying.,Du, Minyi.,Wang, Xiaoying.,Zhang, Jue.,...&Wang, Dongxin.(2013).Quantitative cerebral blood flow mapping and functional connectivity of postherpetic neuralgia pain: A perfusion fMRI study.PAIN,154(1),110-118.
MLA Liu, Jing,et al."Quantitative cerebral blood flow mapping and functional connectivity of postherpetic neuralgia pain: A perfusion fMRI study".PAIN 154.1(2013):110-118.
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