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学科主题: 药学
题名:
Development of a local vasodilator delivery system using fibrin glue to prevent arterial graft from spasm
作者: Qi, Xian-Rong1; Yan, Ying1; Ma, Xu-Dong1; Li, Tao-Yuan1; Nie, Xiao-Yan1; Yang, Bi-Bo1
关键词: fibrin glue ; papaverine ; sustained release ; vasospasm ; carriers
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2007-07-01
DOI: 10.1002/jbm.a.31076
卷: 82A, 期:1, 页:139-144
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: INTERNAL MAMMARY ARTERY ; RADIAL ARTERY ; PAPAVERINE ; VASOSPASM ; PHENOXYBENZAMINE ; CONTRACTION
英文摘要:

The clinical benefits of coronary artery bypass graft operations can be compromised by postoperative vasospasm. Traditionally, local papaverine (PPV) has been employed during the procedure to prevent and counteract vasospasm. But the relatively short action period limited its application. Fibrin glue (FG) might be a potential carrier of PPV for counteracting vasospasm in a longer action period than PPV solution. After FG incorporated with PPV (PPV-FG) was locally administrated in axillary and femoral arteries of dogs, PPV concentrations in artery vessels surrounding the administration sites were compared with the concentrations at the same sites in dogs given PPV solution. The properties of PPV′s release in vitro and maintenance in vessel as well as the influence on the mean peripheral blood pressure and drug concentration in peripheral vein after the introduction PPV-FG on the surface of artery in dogs were evaluated. FG was considered to provide a sustained release of PPV and could maintain a high PPV concentration in artery vessel around the administration site. The results suggested that FG was an effective substrate for reserving PPV in the administrated site in a defined period. (c) 2007 Wiley Periodicals, Inc.

语种: 英语
WOS记录号: WOS:000247089500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50944
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiac Surg, Beijing 100083, Peoples R China

Recommended Citation:
Qi, Xian-Rong,Yan, Ying,Ma, Xu-Dong,et al. Development of a local vasodilator delivery system using fibrin glue to prevent arterial graft from spasm[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2007,82A(1):139-144.
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