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学科主题医学信息学
microRNA evolution in a human transcription factor and microRNA regulatory network
Qiu, Chengxiang1; Wang, Juan1; Yao, Pengying1; Wang, Edwin2; Cui, Qinghua1
刊名BMC SYSTEMS BIOLOGY
2010-06-29
DOI10.1186/1752-0509-4-90
4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mathematical & Computational Biology
研究领域[WOS]Mathematical & Computational Biology
关键词[WOS]SIGNALING NETWORK ; PROTEIN EVOLUTION ; GENES ; ROBUSTNESS ; CANCER ; BACTERIA ; DATABASE ; UPDATE ; TARGET ; SITES
英文摘要

Background: microRNAs (miRNAs) are important cellular components. The understanding of their evolution is of critical importance for the understanding of their function. Although some specific evolutionary rules of miRNAs have been revealed, the rules of miRNA evolution in cellular networks remain largely unexplored. According to knowledge from protein-coding genes, the investigations of gene evolution in the context of biological networks often generate valuable observations that cannot be obtained by traditional approaches.

Results: Here, we conducted the first systems-level analysis of miRNA evolution in a human transcription factor (TF)-miRNA regulatory network that describes the regulatory relations among TFs, miRNAs, and target genes. We found that the architectural structure of the network provides constraints and functional innovations for miRNA evolution and that miRNAs showed different and even opposite evolutionary patterns from TFs and other protein-coding genes. For example, miRNAs preferentially coevolved with their activators but not with their inhibitors. During transcription, rapidly evolving TFs frequently activated but rarely repressed miRNAs. In addition, conserved miRNAs tended to regulate rapidly evolving targets, and upstream miRNAs evolved more rapidly than downstream miRNAs.

Conclusions: In this study, we performed the first systems level analysis of miRNA evolution. The findings suggest that miRNAs have a unique evolution process and thus may have unique functions and roles in various biological processes and diseases. Additionally, the network presented here is the first TF-miRNA regulatory network, which will be a valuable platform of systems biology.

语种英语
WOS记录号WOS:000282255800001
项目编号30900829 ; 20090001120040
资助机构Natural Science Foundation of China ; Ministry of Education of China
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50945
专题北京大学基础医学院_医学信息学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100191, Peoples R China
2.Natl Res Council Canada, Biotechnol Res Inst, Computat Chem & Biol Grp, Montreal, PQ H4P 2R2, Canada
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GB/T 7714
Qiu, Chengxiang,Wang, Juan,Yao, Pengying,et al. microRNA evolution in a human transcription factor and microRNA regulatory network[J]. BMC SYSTEMS BIOLOGY,2010,4.
APA Qiu, Chengxiang,Wang, Juan,Yao, Pengying,Wang, Edwin,&Cui, Qinghua.(2010).microRNA evolution in a human transcription factor and microRNA regulatory network.BMC SYSTEMS BIOLOGY,4.
MLA Qiu, Chengxiang,et al."microRNA evolution in a human transcription factor and microRNA regulatory network".BMC SYSTEMS BIOLOGY 4(2010).
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