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学科主题: 临床医学
题名:
Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery
作者: Wang, Hong-Yi2; Zhang, Jing-Yu1; Cui, Jian-Tao1; Tan, Xiao-Hui1; Li, Wen-Mei1; Gu, Jin2; Lu, You-Yong1
关键词: S100A14 ; S100A4 ; colorectal cancer
刊名: ONCOLOGY REPORTS
发表日期: 2010
DOI: 10.3892/or_00000604
卷: 23, 期:1, 页:45-52
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CALCIUM-BINDING PROTEIN ; SQUAMOUS-CELL CARCINOMA ; PROGNOSTIC-SIGNIFICANCE ; GASTRIC-CANCER ; BREAST-CANCER ; COLON-CARCINOMA ; POOR SURVIVAL ; E-CADHERIN ; FAMILY ; GENE
英文摘要:

To investigate whether S100A14 and S100A4 expression correlates with metastatic potential and prognosis in colorectal cancer (CRC), we firstly used RT-PCR analysis to detect mRNA expression of S100A14 and S100A4 in 40 pairs of fresh tumor samples matched with adjacent normal tissues. We then evaluated the clinical significance of our findings with immunohistochemistry on 115 samples of formalin-fixed and paraffin-embedded tumors on tissue microarrays. Typically, we identified decreased S100A14 mRNA levels (52.5%, 21/40), and increased S100A4 mRNA levels (70.0%, 28/40) in primary CRC samples. In addition, down-regulated or absent S100A14 expression was detected in 56.5% of samples (65/115) and was correlated with poor differentiation (P=0.010). In contrast, overexpressed S100A4 was detected in 57.4% of samples (66/115) and was associated with lymph node metastasis (P=0.001). Simultaneous S100A14 low-expression and S100A4 high-expression was correlated with high CRC metastatic potential (P<0.001). Taken together, the signature derived from the combined expression status of S100A14 and S100A4 could be a valuable prognostic indicator in CRC.

语种: 英语
所属项目编号: 2004 CB518708 ; 2006AA02A402 ; 2006BAI02A14
项目资助者: State Key Basic Research Program ; National Bio-Tech 86-3 ; National Science &amp ; Technology Pillar Program
WOS记录号: WOS:000274133800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50948
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Mol Oncol Lab,Key Lab Carcinogenesis & Translat R, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Surg,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

Recommended Citation:
Wang, Hong-Yi,Zhang, Jing-Yu,Cui, Jian-Tao,et al. Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery[J]. ONCOLOGY REPORTS,2010,23(1):45-52.
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