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The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery
Wang, DX1; Wu, XM1; Li, J1; Xiao, F1; Liu, XY1; Meng, MJ1
刊名ANESTHESIA AND ANALGESIA
2002-11-01
DOI10.1213/01.ANE.0000027870.09122.51
95期:5页:1134-1141
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Anesthesiology
研究领域[WOS]Anesthesiology
关键词[WOS]RETROGRADE CEREBRAL PERFUSION ; OPEN-HEART SURGERY ; CARDIAC-SURGERY ; CARDIOPULMONARY BYPASS ; HIPPOCAMPAL SLICES ; VALVE-REPLACEMENT ; PROTECTION ; ISCHEMIA ; DAMAGE ; BRAIN
英文摘要

We investigated the effect of lidocaine on the incidence of cognitive dysfunction in the early postoperative period after cardiac surgery. One-hundred-eighteen patients undergoing elective coronary artery bypass surgery with cardiopulmonary bypass (CPB) were randon-dzed to receive either lidocaine (1.5 mg/kg bolus followed by a 4 mg/min infusion during operation and 4 mg/kg in the priming solution of CPB) or placebo. A battery of nine neuropsychological tests was administered before and 9 days after surgery. A postoperative deficit in any test was defined as a decline by more than or equal to the preoperative SD of that test in all patients. Any patient showing a deficit in two or more tests was defined as having postoperative cognitive dysfunction. Eighty-eight patients completed pre- and postoperative neuropsychological tests. Plasma lidocaine concentrations (mug/mL) were 4.78 +/- 0.52 (mean +/- SD), 5.38 +/- 0.95, 4.52 +/- 0.39, 5.82 +/- 0.76, and 7.10 +/- 1.09 at 10 min before CPB; 10, 30, and 60 min of CPB; and at the end of operation, respectively. The proportion of patients showing postoperative cognitive dysfunction was significantly reduced in the lidocame group compared with that in the placebo group (18.6% versus 40.0%; P = 0.028). We conclude that intraoperative administration of lidocame decreased the occurrence of cognitive dysfunction in the early postoperative period.

语种英语
WOS记录号WOS:000178912600002
引用统计
被引频次:94[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50951
专题北京大学第二临床医学院_重症医学科
北京大学第一临床医学院_麻醉科
北京大学第一临床医学院_心脏外科
作者单位1.Peking Univ, Hosp 1, Dept Anesthesiol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiac Surg, Beijing 100034, Peoples R China
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GB/T 7714
Wang, DX,Wu, XM,Li, J,et al. The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery[J]. ANESTHESIA AND ANALGESIA,2002,95(5):1134-1141.
APA Wang, DX,Wu, XM,Li, J,Xiao, F,Liu, XY,&Meng, MJ.(2002).The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery.ANESTHESIA AND ANALGESIA,95(5),1134-1141.
MLA Wang, DX,et al."The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery".ANESTHESIA AND ANALGESIA 95.5(2002):1134-1141.
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