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学科主题: 临床医学
题名:
Phospholipids profiling and outcome of peritoneal dialysis patients
作者: Tang, Wen1; Li, Min2; Lu, Xin-Hong1; Liu, Hu-Wei2; Wang, Tao1
关键词: Lipidomics ; mass spectrometry ; peritoneal dialysis ; phospholipids ; sphingomyelin
刊名: BIOMARKERS
发表日期: 2014-09-01
DOI: 10.3109/1354750X.2014.943290
卷: 19, 期:6, 页:505-508
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]: MASS-SPECTROMETRY ; CARDIOVASCULAR-DISEASE ; LIPID-COMPOSITION ; PLASMA ; IDENTIFICATION ; HEMODIALYSIS ; NEPHROPATHY ; BIOMARKERS ; MEMBRANES ; RISK
英文摘要:

Objectives: To investigate phospholipids (PLs) biomarkers in predicting outcome of patients undergoing peritoneal dialysis (PD).

Materials and methods: Twenty PD patients were followed using baseline plasma PLs with an improved online two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry system.

Results: Significant differences were observed in eight PL species with sphingomyelin (SM) and glycerophosphocholine between technical survival (n=15) and failure patients (n=5). Cox regression showed SM 21: 0 (adjusted HR 13.7, 95% CI 2.42-77.88, p=0.003) was independently associated with patients technical failure.

Conclusions: PD failure patients had different plasma PLs profiling as compared with survival patients. Elevated plasma SM 21: 0 level may potentially serve as a biomarker of PD patients at risk for adverse outcomes.

语种: 英语
所属项目编号: 30900681 ; 21175005 ; D131100004713002
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Science and Technology Foundation
WOS记录号: WOS:000340768500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50952
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Div Nephrol, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100191, Peoples R China

Recommended Citation:
Tang, Wen,Li, Min,Lu, Xin-Hong,et al. Phospholipids profiling and outcome of peritoneal dialysis patients[J]. BIOMARKERS,2014,19(6):505-508.
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