IR@PKUHSC  > 北京大学第三临床医学院  > 肾内科
学科主题临床医学
Phospholipids profiling and outcome of peritoneal dialysis patients
Tang, Wen1; Li, Min2; Lu, Xin-Hong1; Liu, Hu-Wei2; Wang, Tao1
关键词Lipidomics Mass Spectrometry Peritoneal Dialysis Phospholipids Sphingomyelin
刊名BIOMARKERS
2014-09-01
DOI10.3109/1354750X.2014.943290
19期:6页:505-508
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]MASS-SPECTROMETRY ; CARDIOVASCULAR-DISEASE ; LIPID-COMPOSITION ; PLASMA ; IDENTIFICATION ; HEMODIALYSIS ; NEPHROPATHY ; BIOMARKERS ; MEMBRANES ; RISK
英文摘要

Objectives: To investigate phospholipids (PLs) biomarkers in predicting outcome of patients undergoing peritoneal dialysis (PD).

Materials and methods: Twenty PD patients were followed using baseline plasma PLs with an improved online two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry system.

Results: Significant differences were observed in eight PL species with sphingomyelin (SM) and glycerophosphocholine between technical survival (n=15) and failure patients (n=5). Cox regression showed SM 21: 0 (adjusted HR 13.7, 95% CI 2.42-77.88, p=0.003) was independently associated with patients technical failure.

Conclusions: PD failure patients had different plasma PLs profiling as compared with survival patients. Elevated plasma SM 21: 0 level may potentially serve as a biomarker of PD patients at risk for adverse outcomes.

语种英语
WOS记录号WOS:000340768500011
项目编号30900681 ; 21175005 ; D131100004713002
资助机构National Natural Science Foundation of China ; Beijing Municipal Science and Technology Foundation
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50952
专题北京大学第三临床医学院_肾内科
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Hosp 3, Div Nephrol, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Tang, Wen,Li, Min,Lu, Xin-Hong,et al. Phospholipids profiling and outcome of peritoneal dialysis patients[J]. BIOMARKERS,2014,19(6):505-508.
APA Tang, Wen,Li, Min,Lu, Xin-Hong,Liu, Hu-Wei,&Wang, Tao.(2014).Phospholipids profiling and outcome of peritoneal dialysis patients.BIOMARKERS,19(6),505-508.
MLA Tang, Wen,et al."Phospholipids profiling and outcome of peritoneal dialysis patients".BIOMARKERS 19.6(2014):505-508.
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