北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 呼吸和危重症医学科  > 期刊论文
学科主题: 临床医学
题名:
Comparative study of clinical pulmonary surfactants using atomic force microscopy
作者: Zhang, Hong1,2; Fan, Qihui1; Wang, Yi E.1; Neal, Charles R.3; Zuo, Yi Y.1
关键词: Surfactant replacement therapy ; Dipalmitoyl phosphatidylcholine ; Cholesterol ; Domain formation ; Surface tension ; Monolayer
刊名: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
发表日期: 2011-07-01
DOI: 10.1016/j.bbamem.2011.03.006
卷: 1808, 期:7, 页:1832-1842
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: RESPIRATORY-DISTRESS-SYNDROME ; ANIMAL-DERIVED SURFACTANTS ; CHRONIC LUNG-DISEASE ; SP-B ; LIPID MONOLAYERS ; SP-C ; INTERFACIAL MONOLAYERS ; LANGMUIR MONOLAYERS ; PHYSICAL-PROPERTIES ; PHOSPHOLIPID FILMS
英文摘要:

Clinical pulmonary surfactant is routinely used to treat premature newborns with respiratory distress syndrome, and has shown great potential in alleviating a number of neonatal and adult respiratory diseases. Despite extensive study of chemical composition, surface activity, and clinical performance of various surfactant preparations, a direct comparison of surfactant films is still lacking. In this study, we use atomic force microscopy to characterize and compare four animal-derived clinical surfactants currently used throughout the world, i.e., Survanta, Curosurf, Infasurf and BLES. These modified-natural surfactants are further compared to dipalmitoyl phosphatidylcholine (DPPC), a synthetic model surfactant of DPPC:palmitoyl-oleoyl phosphatidylglycerol (POPG) (7:3), and endogenous bovine natural surfactant. Atomic force microscopy reveals significant differences in the lateral structure and molecular organization of these surfactant preparations. These differences are discussed in terms of DPPC and cholesterol contents. We conclude that all animal-derived clinical surfactants assume a similar structure of multilayers of fluid phospholipids closely attached to an interfacial monolayer enriched in DPPC, at physiologically relevant surface pressures. This study provides the first comprehensive survey of the lateral structure of clinical surfactants at various surface pressures. It may have clinical implications on future application and development of surfactant preparations. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 44936
项目资助者: University of Hawaii at Manoa ; Hawaii Community Foundation ; Peking University
WOS记录号: WOS:000291172100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50953
Appears in Collections:北京大学第一临床医学院_呼吸和危重症医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Hawaii Manoa, Dept Mech Engn, Honolulu, HI 96822 USA
2.Peking Univ, Hosp 1, Dept Resp Med, Beijing 100034, Peoples R China
3.Univ Hawaii, John A Burns Sch Med, Dept Pediat, Honolulu, HI 96822 USA

Recommended Citation:
Zhang, Hong,Fan, Qihui,Wang, Yi E.,et al. Comparative study of clinical pulmonary surfactants using atomic force microscopy[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2011,1808(7):1832-1842.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Hong]'s Articles
[Fan, Qihui]'s Articles
[Wang, Yi E.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Hong]‘s Articles
[Fan, Qihui]‘s Articles
[Wang, Yi E.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace