学科主题临床医学
Comparative study of clinical pulmonary surfactants using atomic force microscopy
Zhang, Hong1,2; Fan, Qihui1; Wang, Yi E.1; Neal, Charles R.3; Zuo, Yi Y.1
关键词Surfactant Replacement Therapy Dipalmitoyl Phosphatidylcholine Cholesterol Domain Formation Surface Tension Monolayer
刊名BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
2011-07-01
DOI10.1016/j.bbamem.2011.03.006
1808期:7页:1832-1842
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]RESPIRATORY-DISTRESS-SYNDROME ; ANIMAL-DERIVED SURFACTANTS ; CHRONIC LUNG-DISEASE ; SP-B ; LIPID MONOLAYERS ; SP-C ; INTERFACIAL MONOLAYERS ; LANGMUIR MONOLAYERS ; PHYSICAL-PROPERTIES ; PHOSPHOLIPID FILMS
英文摘要

Clinical pulmonary surfactant is routinely used to treat premature newborns with respiratory distress syndrome, and has shown great potential in alleviating a number of neonatal and adult respiratory diseases. Despite extensive study of chemical composition, surface activity, and clinical performance of various surfactant preparations, a direct comparison of surfactant films is still lacking. In this study, we use atomic force microscopy to characterize and compare four animal-derived clinical surfactants currently used throughout the world, i.e., Survanta, Curosurf, Infasurf and BLES. These modified-natural surfactants are further compared to dipalmitoyl phosphatidylcholine (DPPC), a synthetic model surfactant of DPPC:palmitoyl-oleoyl phosphatidylglycerol (POPG) (7:3), and endogenous bovine natural surfactant. Atomic force microscopy reveals significant differences in the lateral structure and molecular organization of these surfactant preparations. These differences are discussed in terms of DPPC and cholesterol contents. We conclude that all animal-derived clinical surfactants assume a similar structure of multilayers of fluid phospholipids closely attached to an interfacial monolayer enriched in DPPC, at physiologically relevant surface pressures. This study provides the first comprehensive survey of the lateral structure of clinical surfactants at various surface pressures. It may have clinical implications on future application and development of surfactant preparations. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000291172100008
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50953
专题北京大学第一临床医学院_呼吸和危重症医学科
作者单位1.Univ Hawaii Manoa, Dept Mech Engn, Honolulu, HI 96822 USA
2.Peking Univ, Hosp 1, Dept Resp Med, Beijing 100034, Peoples R China
3.Univ Hawaii, John A Burns Sch Med, Dept Pediat, Honolulu, HI 96822 USA
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GB/T 7714
Zhang, Hong,Fan, Qihui,Wang, Yi E.,et al. Comparative study of clinical pulmonary surfactants using atomic force microscopy[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2011,1808(7):1832-1842.
APA Zhang, Hong,Fan, Qihui,Wang, Yi E.,Neal, Charles R.,&Zuo, Yi Y..(2011).Comparative study of clinical pulmonary surfactants using atomic force microscopy.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1808(7),1832-1842.
MLA Zhang, Hong,et al."Comparative study of clinical pulmonary surfactants using atomic force microscopy".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1808.7(2011):1832-1842.
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