学科主题 | 药学 |
New triterpene saponins from the roots of Glycyrrhiza yunnanensis and their rapid screening by LC/MS/MS | |
Ji, Shuai1; Wang, Qing1; Qiao, Xue1; Guo, Hong-cheng1; Yang, Yan-fang1; Bo, Tao2; Xiang, Cheng1; Guo, De-an1; Ye, Min1 | |
关键词 | Glycyrrhiza Yunnanensis Glyyunnansapogenin i Lc/ms/ms Triterpene Saponin Yunganoside |
刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2014-03-05 | |
DOI | 10.1016/j.jpba.2013.11.021 |
卷 | 90页:15-26 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Chemistry, Analytical ; Pharmacology & Pharmacy |
资助者 | National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from China Ministry of Education ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from China Ministry of Education |
研究领域[WOS] | Chemistry ; Pharmacology & Pharmacy |
关键词[WOS] | MASS-SPECTROMETRY ; LICORICE ; METABOLITES ; GLYCOSIDES ; STRATEGY ; ESI/MS ; RADIX |
英文摘要 | The roots of Glycyrrhiza yunnanensis Cheng f. et L. K. Dai ex P. C. Li are used as licorice in traditional medicine of Southwest China. Triterpene saponins are the major chemical constituents. In this study, one new oleanane-type triterpenoid, glyyunnansapogenin 1(I), seven new triterpene saponins, yunganosides E3 (II), L (III), M (IV), N1 (V), O (VI), P (VII) and N2 (VIII), together with four known saponins (IX-XII) were isolated from the roots of G. yunnanensis by preparative chromatography. Their structures were identified by spectroscopic analysis including NMR and HR-MS. Based on (-)-ESI-MS/MS fragmentation behaviors of these reference standards, an LC/MS/MS method using neutral loss scan and precursor ion scan on a triple quadrupole mass spectrometer was established to rapidly and comprehensively analyze triterpene saponins in G. yunnanensis. Combined with high-accuracy qTOF mass spectrometry analysis, a total of 50 saponins were detected, and their structures were identified or tentatively characterized. This is the first systematic study on triterpene saponins in G. yunnanensis. (C) 2013 Published by Elsevier B.V. |
语种 | 英语 |
所属项目编号 | 81173644 ; 81222054 ; NCET-11-0019 |
资助者 | National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from China Ministry of Education ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from China Ministry of Education |
WOS记录号 | WOS:000331854600003 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/50958 |
Collection | 北京大学药学院 |
作者单位 | 1.Agilent Technol, Beijing 100102, Peoples R China 2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China |
Recommended Citation GB/T 7714 | Ji, Shuai,Wang, Qing,Qiao, Xue,et al. New triterpene saponins from the roots of Glycyrrhiza yunnanensis and their rapid screening by LC/MS/MS[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2014,90:15-26. |
APA | Ji, Shuai.,Wang, Qing.,Qiao, Xue.,Guo, Hong-cheng.,Yang, Yan-fang.,...&Ye, Min.(2014).New triterpene saponins from the roots of Glycyrrhiza yunnanensis and their rapid screening by LC/MS/MS.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,90,15-26. |
MLA | Ji, Shuai,et al."New triterpene saponins from the roots of Glycyrrhiza yunnanensis and their rapid screening by LC/MS/MS".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 90(2014):15-26. |
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