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New triterpene saponins from the roots of Glycyrrhiza yunnanensis and their rapid screening by LC/MS/MS
Ji, Shuai1; Wang, Qing1; Qiao, Xue1; Guo, Hong-cheng1; Yang, Yan-fang1; Bo, Tao2; Xiang, Cheng1; Guo, De-an1; Ye, Min1
关键词Glycyrrhiza Yunnanensis Glyyunnansapogenin i Lc/ms/ms Triterpene Saponin Yunganoside
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2014-03-05
DOI10.1016/j.jpba.2013.11.021
90页:15-26
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]MASS-SPECTROMETRY ; LICORICE ; METABOLITES ; GLYCOSIDES ; STRATEGY ; ESI/MS ; RADIX
英文摘要

The roots of Glycyrrhiza yunnanensis Cheng f. et L. K. Dai ex P. C. Li are used as licorice in traditional medicine of Southwest China. Triterpene saponins are the major chemical constituents. In this study, one new oleanane-type triterpenoid, glyyunnansapogenin 1(I), seven new triterpene saponins, yunganosides E3 (II), L (III), M (IV), N1 (V), O (VI), P (VII) and N2 (VIII), together with four known saponins (IX-XII) were isolated from the roots of G. yunnanensis by preparative chromatography. Their structures were identified by spectroscopic analysis including NMR and HR-MS. Based on (-)-ESI-MS/MS fragmentation behaviors of these reference standards, an LC/MS/MS method using neutral loss scan and precursor ion scan on a triple quadrupole mass spectrometer was established to rapidly and comprehensively analyze triterpene saponins in G. yunnanensis. Combined with high-accuracy qTOF mass spectrometry analysis, a total of 50 saponins were detected, and their structures were identified or tentatively characterized. This is the first systematic study on triterpene saponins in G. yunnanensis. (C) 2013 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000331854600003
项目编号81173644 ; 81222054 ; NCET-11-0019
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from China Ministry of Education
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50958
专题北京大学药学院
作者单位1.Agilent Technol, Beijing 100102, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ji, Shuai,Wang, Qing,Qiao, Xue,et al. New triterpene saponins from the roots of Glycyrrhiza yunnanensis and their rapid screening by LC/MS/MS[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2014,90:15-26.
APA Ji, Shuai.,Wang, Qing.,Qiao, Xue.,Guo, Hong-cheng.,Yang, Yan-fang.,...&Ye, Min.(2014).New triterpene saponins from the roots of Glycyrrhiza yunnanensis and their rapid screening by LC/MS/MS.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,90,15-26.
MLA Ji, Shuai,et al."New triterpene saponins from the roots of Glycyrrhiza yunnanensis and their rapid screening by LC/MS/MS".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 90(2014):15-26.
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