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学科主题: 临床医学
题名:
High-Dose N-Acetylcysteine in the Prevention of COPD Exacerbations: Rationale and Design of the PANTHEON Study
作者: Zheng, Jin-Ping1; Wen, Fu-Qiang2; Bai, Chun-Xue3; Wan, Huan-Ying4; Kang, Jian5; Chen, Ping6; Yao, Wan-Zhen7; Ma, Li-Jun8; Xia, Qi-kui9; Gao, Yi1; Zhong, Nan-Shan1; PANTHEON Study Comm1
关键词: COPD ; Exacerbation ; N-Acetylcysteine ; ICS ; Quality of Life ; Mucolytics ; Anti-inflammation ; Anti-oxidant
刊名: COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
发表日期: 2013-04-01
DOI: 10.3109/15412555.2012.732628
卷: 10, 期:2, 页:164-171
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Respiratory System
研究领域[WOS]: Respiratory System
关键词[WOS]: OBSTRUCTIVE PULMONARY-DISEASE ; ACETYL-L-CYSTEINE ; IN-VITRO ; TRIAL ; CARBOCISTEINE ; INFLAMMATION ; BRONCHITIS ; RISK
英文摘要:

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation; from a pathophysiological point of view it involves many components, including mucus hypersecretion, oxidative stress and inflammation. N-acetylcysteine (NAC) is a mucolytic agent with antioxidant and anti-inflammatory properties. Long-term efficacy of NAC 600mg/d in COPD is controversial; a dose-effect relationship has been demonstrated, but at present it is not known whether a higher dose provides clinical benefits. The PANTHEON Study is a prospective, ICS stratified, randomized, double-blind, placebo-controlled, parallel-group, multi-center trial designed to assess the efficacy and safety of high-dose (1200 mg/daily) NAC treatment for one year in moderate-to-severe COPD patients. The primary endpoint is the annual exacerbation rate. Secondary endpoints include recurrent exacerbations hazard ratio, time to first exacerbation, as well as quality of life and pulmonary function. The hypothesis, design and methodology are described and baseline characteristics of recruited patients are presented. 1006 COPD patients (444 treated with maintenance ICS, 562 ICS naive, aged 66.27 +/- 8.76 yrs, average post-bronchodilator FEV1 48.95 +/- 11.80 of predicted) have been randomized at 34 hospitals in China. Final results of this study will provide objective data on the effects of high-dose (1200 mg/daily) long-term NAC treatment in the prevention of COPD exacerbations and other outcome variables.

语种: 英语
项目资助者: Hainan Zambon Pharmaceutical Co., Ltd.
WOS记录号: WOS:000316954500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50965
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China
2.China Med Univ, Affiliated Hosp 1, Shenyang, Peoples R China
3.Shenyang PLA Gen Hosp, Shenyang, Peoples R China
4.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
5.Henan Prov Peoples Hosp, Zhengzhou, Peoples R China
6.Fudan Univ, Publ Hlth Univ, Shanghai 200433, Peoples R China
7.Sichuan Univ, Huaxi Hosp, Chengdu 610064, Peoples R China
8.Guangzhou Med Univ, State Key Lab Resp Dis, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
9.Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Shanghai, Peoples R China

Recommended Citation:
Zheng, Jin-Ping,Wen, Fu-Qiang,Bai, Chun-Xue,et al. High-Dose N-Acetylcysteine in the Prevention of COPD Exacerbations: Rationale and Design of the PANTHEON Study[J]. COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,2013,10(2):164-171.
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