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学科主题: 临床医学
题名:
Lanthanum Acetate Inhibits Vascular Calcification Induced by Vitamin D3 Plus Nicotine in Rats
作者: Zhou, Ye-Bo1; Jin, Shao-Ju2; Cai, Yan1; Teng, Xu1; Chen, Li3; Tang, Chao-Shu1,3; Qi, Yong-Fen1,3,4
关键词: vascular calcification ; lanthanum acetate ; type III sodium dependent phosphate cotransporter Pit-1 ; matrix Gla-protein
刊名: EXPERIMENTAL BIOLOGY AND MEDICINE
发表日期: 2009-08-01
DOI: 10.3181/0811-RM-346
卷: 234, 期:8, 页:908-917
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; HYPERVITAMINOSIS-D ; CORONARY CALCIUM ; PHOSPHATE ; CARBONATE ; MECHANISM ; BISPHOSPHONATES ; CONTRACTION ; EFFICACY ; THERAPY
英文摘要:

Lanthanum, a rare earth element, has been used to decrease serum phosphorus level in patients with chronic renal disease and hyperphosphatemia. We aimed to observe the effect and mechanism of two doses of lanthanum acetate (375 and 750 mg/kg/day) on vascular calcification induced by vitamin D3 plus nicotine treatment in rats for 4 weeks. As compared with control rats, rats with calcification showed widespread calcified nodules and irregular elastic fibers in calcified aorta on von Kossa calcium staining and increased aortic calcium and phosphorus contents, alkaline phosphatase (ALP) activity and bone-related protein expressions for osteopontin (OPN) and type III sodium dependent phosphate cotransporter Pit-1 (Pit-1). After treatment with either dose of lanthanum acetate, the calcified nodules and degree of irregular elastic fibers decreased in aortas. Lanthanum acetate at 750 mg/kg/day was more effective than 375 mg/kg/day in lessening vascular calcification by significantly reducing plasma phosphorus level, calcium x phosphorus product and ALP activity, by 30.3%, 28.6%, and 68.6%, respectively; reducing aortic phosphorus and calcium contents and ALP activity, by 48%, 53.1%, and 63.5% (all P<0.01), respectively; reducing aortic mRNA level of OPN and Pit-1, by 55.8% (P<0.01) and 38.8% (P<0.05) and protein level of OPN and Pit-1, by 37.2% and 27.2% (both P<0.01), respectively; and increasing carboxylated matrix Gla-protein (MGP) protein expression by 33.7% (P<0.05), as compared with rats treated with vitamin D3 and nicotine alone. Lanthanum acetate could effectively inhibit the pathogenesis of vascular calcification. Exp Biol Med 234:908-917, 2009

语种: 英语
所属项目编号: NCET-05-0016 ; 30470693 ; 30871013 ; 2006CB503807
项目资助者: The Program for New Century Excellent Talents in University, of the Education Ministry of China ; National Natural Science Foundation of China ; State Major Basic Research Development Program of the People&prime ; s Republic of China
WOS记录号: WOS:000268567300005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50966
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.NingXia Med Univ, Dept Pharmacol, Yinchuan 750004, Peoples R China
4.Peking Univ, Hosp 1, Inst Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Ye-Bo,Jin, Shao-Ju,Cai, Yan,et al. Lanthanum Acetate Inhibits Vascular Calcification Induced by Vitamin D3 Plus Nicotine in Rats[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2009,234(8):908-917.
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