IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科
学科主题临床医学
Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients
Che, Li; Yuan, Yan-Hua; Jia, Jun; Ren, Jun
关键词Hepatocellular Carcinoma Hedgehog Gli1 Sonic Hedgehog Patched Smoothened Prognosis
刊名CHINESE JOURNAL OF CANCER RESEARCH
2012-12-01
DOI10.3978/j.issn.1000-9604.2012.10.10
24期:4页:323-331
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Basic Research Program of China ("973" Program) ; Capital Development Grant ; National Basic Research Program of China ("973" Program) ; Capital Development Grant
研究领域[WOS]Oncology
关键词[WOS]PRIMARY BILIARY-CIRRHOSIS ; BASAL-CELL CARCINOMA ; BREAST-CANCER ; THERAPEUTIC TARGET ; STROMAL CELLS ; HUMAN HOMOLOG ; LUNG-CANCER ; MUTATIONS ; CYCLOPAMINE ; INHIBITION
英文摘要

Objective: The activation of hedgehog (HH) pathway is implicated in the development of human malignancies including hepatocellular carcinoma (HCC). However, the clinical impact of HH activation in HCC patients is still unclear. This study was conducted to confirm whether the expression of HH pathway components was associated with HCC progression and clinical outcome.

Methods: This study was a sample-expanded and prolonged follow up of one of our previous studies. It included 46 HCC patients who underwent surgical treatment from 2002 to 2005. The expression of sonic HH (SHH), patched-1 (PTCH1), smoothened (SMOH) and glioma-associated oncogene-1 (GLI1) genes in tumor and adjacent normal tissues extracted from the patients were examined by reverse transcription-polymerase chain reaction (RT-PCR) to explore the relationship between these genes and the clinical prognosis of HCC.

Results: The expression levels of SHH, PTCH1, SMOH and GUY in HCC tissues were 60.87%, 50.00%, 32.61% and 54.35%, respectively. The expression levels of SHH-related molecules were relatively intense in cancer tissue, but insignificantly correlated with any clinicopathological factors of tumor. Transcriptional factor GM was the only molecule associated with poor prognosis among the HCC patients. The expression of GLI1 gene in tumor tissues was significantly related with disease-free survival (DFS) (P=0.042) and overall survival (OS) (P=0.030). The simultaneous expression of GLI1 in tumor and adjacent normal liver tissues correlated with DFS (P<0.029) and OS (P<0.025).

Conclusions: HH signaling activation is an important event in the development of human HCC. The expression of GLI1 in SHH pathway is possibly involved in HCC progression, which may be a useful prognostic indicator of HCC.

语种英语
所属项目编号2009CB521700 ; 2007-2053
资助者National Basic Research Program of China ("973" Program) ; Capital Development Grant ; National Basic Research Program of China ("973" Program) ; Capital Development Grant
WOS记录号WOS:000314793100012
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50967
Collection北京大学临床肿瘤学院_肿瘤内科
作者单位Peking Univ Canc Hosp & Inst, Dept Med Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
Recommended Citation
GB/T 7714
Che, Li,Yuan, Yan-Hua,Jia, Jun,et al. Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients[J]. CHINESE JOURNAL OF CANCER RESEARCH,2012,24(4):323-331.
APA Che, Li,Yuan, Yan-Hua,Jia, Jun,&Ren, Jun.(2012).Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients.CHINESE JOURNAL OF CANCER RESEARCH,24(4),323-331.
MLA Che, Li,et al."Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients".CHINESE JOURNAL OF CANCER RESEARCH 24.4(2012):323-331.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Che, Li]'s Articles
[Yuan, Yan-Hua]'s Articles
[Jia, Jun]'s Articles
百度学术
百度学术Similar articles in
[Che, Li]'s Articles
[Yuan, Yan-Hua]'s Articles
[Jia, Jun]'s Articles
必应学术
必应学术Similar articles in
[Che, Li]'s Articles
[Yuan, Yan-Hua]'s Articles
[Jia, Jun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.