|Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients|
|Che, Li; Yuan, Yan-Hua; Jia, Jun; Ren, Jun|
|关键词||Hepatocellular Carcinoma Hedgehog Gli1 Sonic Hedgehog Patched Smoothened Prognosis|
|刊名||CHINESE JOURNAL OF CANCER RESEARCH|
|WOS标题词||Science & Technology|
|关键词[WOS]||PRIMARY BILIARY-CIRRHOSIS ; BASAL-CELL CARCINOMA ; BREAST-CANCER ; THERAPEUTIC TARGET ; STROMAL CELLS ; HUMAN HOMOLOG ; LUNG-CANCER ; MUTATIONS ; CYCLOPAMINE ; INHIBITION|
Objective: The activation of hedgehog (HH) pathway is implicated in the development of human malignancies including hepatocellular carcinoma (HCC). However, the clinical impact of HH activation in HCC patients is still unclear. This study was conducted to confirm whether the expression of HH pathway components was associated with HCC progression and clinical outcome.
Methods: This study was a sample-expanded and prolonged follow up of one of our previous studies. It included 46 HCC patients who underwent surgical treatment from 2002 to 2005. The expression of sonic HH (SHH), patched-1 (PTCH1), smoothened (SMOH) and glioma-associated oncogene-1 (GLI1) genes in tumor and adjacent normal tissues extracted from the patients were examined by reverse transcription-polymerase chain reaction (RT-PCR) to explore the relationship between these genes and the clinical prognosis of HCC.
Results: The expression levels of SHH, PTCH1, SMOH and GUY in HCC tissues were 60.87%, 50.00%, 32.61% and 54.35%, respectively. The expression levels of SHH-related molecules were relatively intense in cancer tissue, but insignificantly correlated with any clinicopathological factors of tumor. Transcriptional factor GM was the only molecule associated with poor prognosis among the HCC patients. The expression of GLI1 gene in tumor tissues was significantly related with disease-free survival (DFS) (P=0.042) and overall survival (OS) (P=0.030). The simultaneous expression of GLI1 in tumor and adjacent normal liver tissues correlated with DFS (P<0.029) and OS (P<0.025).
Conclusions: HH signaling activation is an important event in the development of human HCC. The expression of GLI1 in SHH pathway is possibly involved in HCC progression, which may be a useful prognostic indicator of HCC.
|项目编号||2009CB521700 ; 2007-2053|
|资助机构||National Basic Research Program of China ("973" Program) ; Capital Development Grant|
|作者单位||Peking Univ Canc Hosp & Inst, Dept Med Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China|
|Che, Li,Yuan, Yan-Hua,Jia, Jun,et al. Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients[J]. CHINESE JOURNAL OF CANCER RESEARCH,2012,24(4):323-331.|
|APA||Che, Li,Yuan, Yan-Hua,Jia, Jun,&Ren, Jun.(2012).Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients.CHINESE JOURNAL OF CANCER RESEARCH,24(4),323-331.|
|MLA||Che, Li,et al."Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients".CHINESE JOURNAL OF CANCER RESEARCH 24.4(2012):323-331.|