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学科主题临床医学
Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer
Xing, Xiao-Fang1; Li, Hong2; Zhong, Xi-Yao1; Zhang, Lian-Hai1; Wang, Xiao-Hong1; Liu, Yi-Qiang1,2; Jia, Shu-Qin1; Shi, Tao1; Niu, Zhao-Jian3; Peng, Yong1; Du, Hong4; Zhang, Gui-Guo4; Hu, Ying4; Lu, Ai-Ping5; Li, Ji-You5; Chen, She2; Ji, Jia-Fu1
关键词Intestinal Metaplasia Phospholipase A2 Group Iia Prognosis Stomach Neoplasms
刊名HISTOPATHOLOGY
2011-08-01
DOI10.1111/j.1365-2559.2011.03913.x
59期:2页:198-206
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; SECRETORY PHOSPHOLIPASE-A2 ; COLORECTAL-CARCINOMA ; PANETH CELLS ; PLA2G2A ; TUMORIGENESIS ; NSAIDS ; MICE ; A(2) ; ADENOCARCINOMA
英文摘要

Aims: The secreted phospholipase A2 type IIA (PLA2G2A) gene has been identified as a modifier of intestinal adenoma multiplicity in Apc(Min/+) mice. The aim of the present study was to analyse the clinical significance of PLA2G2A expression in human gastric cancer.

Methods and results: Using immunohistochemistry, cytoplasmic immunoreactivity of PLA2G2A was observed in 27% (40 of 149) of gastric cancer tissues compared with negative staining in normal mucosa. The PLA2G2A expression rate in well-differentiated carcinoma was elevated significantly compared with that in poorly differentiated carcinoma (46% versus 19%, P = 0.001). Statistical analysis also revealed that PLA2G2A expression correlated negatively with depth of mural invasion, lymph node metastasis and tumour-node-metastasis (TNM) stage (P < 0.05). Patients with positive PLA2G2A expression showed higher 5-year overall survival than those with negative expression (P = 0.0004). In intestinal metaplasia, PLA2G2A was found to be abundant in Paneth cells. The coexistence of PLA2G2A and lysozyme was observed in Paneth cell-rich gastric cancer (P < 0.0001).

Conclusions: PLA2G2A may predict survival and might be a potential biomarker for early detection and individualized therapy.

语种英语
WOS记录号WOS:000294786300005
项目编号30471677 ; D0905001040631
资助机构National Natural Science Foundation of China ; Foundation of Beijing Municipal Committee of Science and Technology
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50971
专题北京大学临床肿瘤学院_肿瘤外科
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_标本库
作者单位1.Natl Inst Biol Sci, Beijing, Peoples R China
2.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Surg, Minist Educ, Beijing, Peoples R China
3.Shandong Univ, Qilu Hosp, Dept Gen Surg, Jinan 250100, Shandong, Peoples R China
4.Peking Univ Canc Hosp & Inst, Tissue Bank, Beijing, Peoples R China
5.Peking Univ Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China
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Xing, Xiao-Fang,Li, Hong,Zhong, Xi-Yao,et al. Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer[J]. HISTOPATHOLOGY,2011,59(2):198-206.
APA Xing, Xiao-Fang.,Li, Hong.,Zhong, Xi-Yao.,Zhang, Lian-Hai.,Wang, Xiao-Hong.,...&Ji, Jia-Fu.(2011).Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer.HISTOPATHOLOGY,59(2),198-206.
MLA Xing, Xiao-Fang,et al."Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer".HISTOPATHOLOGY 59.2(2011):198-206.
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