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Ultrastructural features and expression of cytoskeleton proteins of podocyte from patients with minimal change disease and focal segmental glomerulosclerosis
Shi, Su-Fang; Wang, Su-Xia; Zhang, You-Kang; Zhao, Ming-Hui; Zou, Wan-Zhong
关键词Proteinuria Podocyte Cytoskeleton Proteins Microscopy Electron Immunogold Labeling
刊名RENAL FAILURE
2008
DOI10.1080/08860220802060497
30期:5页:477-483
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]CHANGE NEPHROTIC SYNDROME ; HUMAN GLOMERULOPATHIES ; ALPHA-ACTININ-4 ; NEPHRIN ; EFFACEMENT ; BIOLOGY ; DAMAGE ; MICE
英文摘要

Focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) have been suggested for the category of podocytopathies. An ultrastructural observation and immunogold labeling for cytoskeleton proteins of podocytes on 11 cases each of FSGS and MCD were performed. Compared to MCD, more severe ultrastructural alterations of podocyte were identified in FSGS, which were characterized by higher frequency of mat-like condensation of microfilaments in the foot process and the detachment of the foot process from glomerular basement membrane. The labeling of alpha-actinin of podocytes in FSGS was significantly higher than MCD, which suggested an abnormal expression of cytoskeleton protein of podocyte in FSGS. The present study demonstrated a much more severe podocyte injury at the ultrastructural level in FSGS than in MCD.

语种英语
WOS记录号WOS:000257070000001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50978
专题北京大学第一临床医学院
北京大学基础医学院
北京大学第一临床医学院_电镜室
北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Hosp 1, Key Lab Renal Dis,Minist Hlth China, Inst Nephrol,Dept Med,Renal Div, Beijing 100034, Peoples R China
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GB/T 7714
Shi, Su-Fang,Wang, Su-Xia,Zhang, You-Kang,et al. Ultrastructural features and expression of cytoskeleton proteins of podocyte from patients with minimal change disease and focal segmental glomerulosclerosis[J]. RENAL FAILURE,2008,30(5):477-483.
APA Shi, Su-Fang,Wang, Su-Xia,Zhang, You-Kang,Zhao, Ming-Hui,&Zou, Wan-Zhong.(2008).Ultrastructural features and expression of cytoskeleton proteins of podocyte from patients with minimal change disease and focal segmental glomerulosclerosis.RENAL FAILURE,30(5),477-483.
MLA Shi, Su-Fang,et al."Ultrastructural features and expression of cytoskeleton proteins of podocyte from patients with minimal change disease and focal segmental glomerulosclerosis".RENAL FAILURE 30.5(2008):477-483.
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