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学科主题: 临床医学
题名:
Ultrastructural features and expression of cytoskeleton proteins of podocyte from patients with minimal change disease and focal segmental glomerulosclerosis
作者: Shi, Su-Fang; Wang, Su-Xia; Zhang, You-Kang; Zhao, Ming-Hui; Zou, Wan-Zhong
关键词: proteinuria ; podocyte ; cytoskeleton proteins ; microscopy electron ; immunogold labeling
刊名: RENAL FAILURE
发表日期: 2008
DOI: 10.1080/08860220802060497
卷: 30, 期:5, 页:477-483
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHANGE NEPHROTIC SYNDROME ; HUMAN GLOMERULOPATHIES ; ALPHA-ACTININ-4 ; NEPHRIN ; EFFACEMENT ; BIOLOGY ; DAMAGE ; MICE
英文摘要:

Focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) have been suggested for the category of podocytopathies. An ultrastructural observation and immunogold labeling for cytoskeleton proteins of podocytes on 11 cases each of FSGS and MCD were performed. Compared to MCD, more severe ultrastructural alterations of podocyte were identified in FSGS, which were characterized by higher frequency of mat-like condensation of microfilaments in the foot process and the detachment of the foot process from glomerular basement membrane. The labeling of alpha-actinin of podocytes in FSGS was significantly higher than MCD, which suggested an abnormal expression of cytoskeleton protein of podocyte in FSGS. The present study demonstrated a much more severe podocyte injury at the ultrastructural level in FSGS than in MCD.

语种: 英语
WOS记录号: WOS:000257070000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50978
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Key Lab Renal Dis,Minist Hlth China, Inst Nephrol,Dept Med,Renal Div, Beijing 100034, Peoples R China

Recommended Citation:
Shi, Su-Fang,Wang, Su-Xia,Zhang, You-Kang,et al. Ultrastructural features and expression of cytoskeleton proteins of podocyte from patients with minimal change disease and focal segmental glomerulosclerosis[J]. RENAL FAILURE,2008,30(5):477-483.
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