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学科主题: 基础医学
题名:
Psammoma bodies in two types of human ovarian tumours: a mineralogical study
作者: Meng Fanlu1; Wang Changqiu1; Li Yan1; Lu Anhuai1; Mei Fang2; Liu Jianying2; Du Jingyun3; Zhang Yan1
刊名: MINERALOGY AND PETROLOGY
发表日期: 2015-06-01
DOI: 10.1007/s00710-014-0342-6
卷: 109, 期:3, 页:357-365
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Geochemistry & Geophysics ; Mineralogy
研究领域[WOS]: Geochemistry & Geophysics ; Mineralogy
关键词[WOS]: CANCER ; COLLAGEN ; NANOBACTERIA ; NUCLEATION ; CRYSTAL ; SITES ; BODY
英文摘要:

Psammoma body (PB) is a common form of calcification in pathological diagnosis and closely relevant to tumours. This paper focuses on the mineralogical characteristics of PBs in ovarian serous cancer and teratoma by using polarization microscope (POM), environmental scanning electron microscope (ESEM), micro-Fourier transform infrared spectroscopy (micro-FT-IR), transmission electron microscope (TEM), micro-area synchrotron radiation X-ray powder diffraction (mu-SRXRD) and fluorescence (mu-SRXRF). Both the PBs in tissues and separated from eight typical cases were investigated. POM and ESEM observation revealed the inside-out growth pattern of PBs. mu-SRXRD and micro-FT-IR results demonstrated the dominant mineral phase of PBs in ovarian serous cancer and teratoma was AB-type carbonate hydroxyapatite (Ca-10[(PO4)(6-x-y)(CO3)(x)(HPO4 (2-))(y)][(OH)(2-u)(CO3)(u)] with 0 a parts per thousand currency signaEuro parts per thousand x,y,u a parts per thousand currency signaEuro parts per thousand 2). As observed by ESEM and TEM, the layer-rich PBs in teratoma were up to 70 mu m and mainly consisted of 5 nm-wide, 5-12 nm-long columnar crystals; the PBs in ovarian serous cancer with a maximum diameter of 35 mu m were composed of slightly longer columnar crystals and granulates with 20-100 nm in diameter. The selected area electron diffraction patterns showed dispersed polycrystalline diffraction rings with arching behavior of (002) diffraction, indicating the aggregated nanocrystals grew in the preferred orientation of (002) face. The EDX and mu-SRXRF results together indicated the existence of Na, Mg, Zn and Sr in PBs. These detailed mineralogical characteristics may help uncover the nature of the pathological PBs in ovary.

语种: 英语
所属项目编号: 41272048 ; 40872196
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000355220800010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50986
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Earth & Space Sci, Key Lab Orogen Belts & Crustal Evolut, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China
3.Chaihu Hlth Ctr Zhongxiang, Dept Pathol, Zhongxiang, Hubei, Peoples R China

Recommended Citation:
Meng Fanlu,Wang Changqiu,Li Yan,et al. Psammoma bodies in two types of human ovarian tumours: a mineralogical study[J]. MINERALOGY AND PETROLOGY,2015,109(3):357-365.
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