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学科主题基础医学
Psammoma bodies in two types of human ovarian tumours: a mineralogical study
Meng Fanlu1; Wang Changqiu1; Li Yan1; Lu Anhuai1; Mei Fang2; Liu Jianying2; Du Jingyun3; Zhang Yan1
刊名MINERALOGY AND PETROLOGY
2015-06-01
DOI10.1007/s00710-014-0342-6
109期:3页:357-365
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geochemistry & Geophysics ; Mineralogy
研究领域[WOS]Geochemistry & Geophysics ; Mineralogy
关键词[WOS]CANCER ; COLLAGEN ; NANOBACTERIA ; NUCLEATION ; CRYSTAL ; SITES ; BODY
英文摘要

Psammoma body (PB) is a common form of calcification in pathological diagnosis and closely relevant to tumours. This paper focuses on the mineralogical characteristics of PBs in ovarian serous cancer and teratoma by using polarization microscope (POM), environmental scanning electron microscope (ESEM), micro-Fourier transform infrared spectroscopy (micro-FT-IR), transmission electron microscope (TEM), micro-area synchrotron radiation X-ray powder diffraction (mu-SRXRD) and fluorescence (mu-SRXRF). Both the PBs in tissues and separated from eight typical cases were investigated. POM and ESEM observation revealed the inside-out growth pattern of PBs. mu-SRXRD and micro-FT-IR results demonstrated the dominant mineral phase of PBs in ovarian serous cancer and teratoma was AB-type carbonate hydroxyapatite (Ca-10[(PO4)(6-x-y)(CO3)(x)(HPO4 (2-))(y)][(OH)(2-u)(CO3)(u)] with 0 a parts per thousand currency signaEuro parts per thousand x,y,u a parts per thousand currency signaEuro parts per thousand 2). As observed by ESEM and TEM, the layer-rich PBs in teratoma were up to 70 mu m and mainly consisted of 5 nm-wide, 5-12 nm-long columnar crystals; the PBs in ovarian serous cancer with a maximum diameter of 35 mu m were composed of slightly longer columnar crystals and granulates with 20-100 nm in diameter. The selected area electron diffraction patterns showed dispersed polycrystalline diffraction rings with arching behavior of (002) diffraction, indicating the aggregated nanocrystals grew in the preferred orientation of (002) face. The EDX and mu-SRXRF results together indicated the existence of Na, Mg, Zn and Sr in PBs. These detailed mineralogical characteristics may help uncover the nature of the pathological PBs in ovary.

语种英语
WOS记录号WOS:000355220800010
项目编号41272048 ; 40872196
资助机构National Natural Science Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50986
专题北京大学基础医学院_病理学系
北京大学基础医学院
作者单位1.Peking Univ, Sch Earth & Space Sci, Key Lab Orogen Belts & Crustal Evolut, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China
3.Chaihu Hlth Ctr Zhongxiang, Dept Pathol, Zhongxiang, Hubei, Peoples R China
推荐引用方式
GB/T 7714
Meng Fanlu,Wang Changqiu,Li Yan,et al. Psammoma bodies in two types of human ovarian tumours: a mineralogical study[J]. MINERALOGY AND PETROLOGY,2015,109(3):357-365.
APA Meng Fanlu.,Wang Changqiu.,Li Yan.,Lu Anhuai.,Mei Fang.,...&Zhang Yan.(2015).Psammoma bodies in two types of human ovarian tumours: a mineralogical study.MINERALOGY AND PETROLOGY,109(3),357-365.
MLA Meng Fanlu,et al."Psammoma bodies in two types of human ovarian tumours: a mineralogical study".MINERALOGY AND PETROLOGY 109.3(2015):357-365.
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