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学科主题: 临床医学
题名:
Genome-wide association study identifies susceptibility loci for IgA nephropathy
作者: Gharavi, Ali G.1; Kiryluk, Krzysztof1; Choi, Murim2; Li, Yifu1; Hou, Ping1,3; Xie, Jingyuan1,4; Sanna-Cherchi, Simone1; Men, Clara J.2; Julian, Bruce A.5,6; Wyatt, Robert J.7,8; Novak, Jan5,6; He, John C.9; Wang, Haiyan3; Lv, Jicheng3; Zhu, Li3; Wang, Weiming4; Wang, Zhaohui4; Yasuno, Kasuhito2; Gunel, Murat2; Mane, Shrikant2,10; Umlauf, Sheila2,10; Tikhonova, Irina2,10; Beerman, Isabel2; Savoldi, Silvana11; Magistroni, Riccardo12; Ghiggeri, Gian Marco13; Bodria, Monica13; Lugani, Francesca1,13; Ravani, Pietro14; Ponticelli, Claudio15; Allegri, Landino16; Boscutti, Giuliano17; Frasca, Giovanni18; Amore, Alessandro19; Peruzzi, Licia19; Coppo, Rosanna19; Izzi, Claudia20,21; Viola, Battista Fabio22; Prati, Elisabetta23; Salvadori, Maurizio24; Mignani, Renzo25; Gesualdo, Loreto26; Bertinetto, Francesca27; Mesiano, Paola27; Amoroso, Antonio27; Scolari, Francesco20,21; Chen, Nan4; Zhang, Hong3; Lifton, Richard P.2
刊名: NATURE GENETICS
发表日期: 2011-04-01
DOI: 10.1038/ng.787
卷: 43, 期:4, 页:321-U68
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: GALACTOSE-DEFICIENT IGA1 ; MACULAR DEGENERATION ; HLA-DR ; RISK ; VARIANTS ; DISEASE ; CFH ; GLOMERULONEPHRITIS ; HAPLOTYPE ; LINKAGE
英文摘要:

We carried out a genome-wide association study of IgA nephropathy, a major cause of kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han ancestry, with targeted follow up in Chinese and European cohorts comprising 1,950 cases and 1,920 controls. We identified three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome 1q32 and a locus at chromosome 22q12 that each surpassed genome-wide significance (P values for association between 1.59 x 10(-26) and 4.84 x 10(-9) and minor allele odds ratios of 0.63-0.80). These five loci explain 4-7% of the disease variance and up to a tenfold variation in interindividual risk. Many of the alleles that protect against IgA nephropathy impart increased risk for other autoimmune or infectious diseases, and IgA nephropathy risk allele frequencies closely parallel the variation in disease prevalence among Asian, European and African populations, suggesting complex selective pressures.

语种: 英语
所属项目编号: RC1DK087445 ; R01DK082753 ; KL2 RR24157
项目资助者: Center for Glomerular Diseases at Columbia University ; Yale Center ; Yale Center for Human Genetics and Genomics
WOS记录号: WOS:000288903700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50989
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Univ Calgary, Calgary, AB T2N 1N4, Canada
2.Spedali Civil Brescia, Div Nephrol, I-25125 Brescia, Italy
3.Osped Desenzano, Dialysis Ctr, Desenzano Del Garda, Italy
4.Careggi Univ Hosp, Renal Unit, Florence, Italy
5.Osped Infermi, Div Nephrol, Rimini, Italy
6.Univ Foggia, Dept Biomed Sci, Foggia, Italy
7.Bonheur Childrens Hosp, Childrens Fdn, Res Ctr, Memphis, TN USA
8.Ist Sci Humanitas, Div Nefrol & Dialisi, Milan, Italy
9.Osped Gorizia, Dept Nephrol, Gorizia, Italy
10.Mt Sinai Sch Med, Dept Med, York, NY USA
11.Osped Riuniti, Nephrol & Dialysis Unit, Ancona, Italy
12.Univ Turin, Dept Genet Biol & Biochem, Turin, Italy
13.Yale Univ, Sch Med, Yale Ctr Genome Anal, New Haven, CT 06510 USA
14.Cirie Hosp, Nephrol & Dialysis Unit, Turin, Italy
15.Uremia Ist Giannina Gaslini, Lab Pathophysiol, Genoa, Italy
16.Regina Margherita Univ Hosp, Turin, Italy
17.Univ Brescia, Montichiari, Italy
18.Montichiari Hosp, Div Nephrol 2, Montichiari, Italy
19.Columbia Univ, Dept Med, Coll Phys & Surg, New York, NY 10027 USA
20.Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, New Haven, CT 06510 USA
21.Peking Univ, Renal Div, Hosp 1, Inst Nephrol,Key Lab Renal Dis,Minist Hlth China, Beijing 100871, Peoples R China
22.Shanghai Jiao Tong Univ, Dept Nephrol, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China
23.Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA
24.Univ Alabama, Dept Med, Birmingham, AL 35294 USA
25.Univ Tennessee, Ctr Hlth Sci, Div Pediat Nephrol, Memphis, TN 38163 USA
26.Univ Policlin Modena, Div Nefrol Dialisi & Trapianto, Azienda Osped, Modena, Italy
27.Univ Parma, Nephrol Sect, Dept Clin Med Nephrol & Hlth Sci, I-43100 Parma, Italy

Recommended Citation:
Gharavi, Ali G.,Kiryluk, Krzysztof,Choi, Murim,et al. Genome-wide association study identifies susceptibility loci for IgA nephropathy[J]. NATURE GENETICS,2011,43(4):321-U68.
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