IR@PKUHSC  > 北京大学第二临床医学院  > 血管外科
学科主题临床医学
Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty
Ma, Bingbing1; Liang, Gangzhu1; Zhang, Fuxian1; Chen, Yizhi2; Zhang, Huan1
关键词Hydrogen Sulfide Atherosclerosis Peripheral Artery Disease Percutaneous Transluminal Angioplasty Smooth Muscle Cell Neointimal Hyperplasia Restenosis
刊名MOLECULAR MEDICINE REPORTS
2012-06-01
DOI10.3892/mmr.2012.853
5期:6页:1497-1502
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]CELL-PROLIFERATION ; ATHEROSCLEROSIS ; MODEL ; DISEASE ; H2S
英文摘要

Peripheral artery disease (PAD) may lead to a poor quality of life. Although percutaneous transluminal angioplasty (PTA) is widely used for the treatment of PAD, restenosis remains a major drawback. Hydrogen sulfide (H,S) plays potential roles in many physiological processes, such as vasodilatation and inhibition of smooth muscle cell proliferation. However, little is known regarding its role in arterial restenosis. In this study, we induced atherosclerotic-like lesions in rabbits, and we treated the rabbits with balloon angioplasty (BA) in a similar manner as PTA performed in the clinic. The rabbits were treated with sodium hydrosulfide (NaHS, a donor of H,S) or DL-propargylglycine (PPG, an inhibitor of H,S synthase). Treatment with NaHS significantly inhibited arterial restenosis following BA by reducing the intimal area and the intima/media ratio, while PPG treatment had a tendency to result in more severe restenosis. NaHS treatment significantly reduced smooth muscle cell (SMC) proliferation and elevated SMC apoptosis in the neointima. In contrast, PPG induced a significant increase in SMC proliferation. In conclusion, H2S attenuates the progression of neointimal hyperplasia and inhibits restenosis after BA. This discovery may lead to potential novel therapies, which can improve the prognosis of PAD patients.

语种英语
WOS记录号WOS:000304182300024
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50990
专题北京大学第二临床医学院_血管外科
北京大学第一临床医学院_普通外科
作者单位1.Peking Univ, Clin Hosp 9, Beijing Shijitan Hosp, Dept Vasc Surg, Beijing 100038, Peoples R China
2.Peking Univ, Clin Hosp 9, Beijing Shijitan Hosp, Dept Pathol, Beijing 100038, Peoples R China
推荐引用方式
GB/T 7714
Ma, Bingbing,Liang, Gangzhu,Zhang, Fuxian,et al. Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty[J]. MOLECULAR MEDICINE REPORTS,2012,5(6):1497-1502.
APA Ma, Bingbing,Liang, Gangzhu,Zhang, Fuxian,Chen, Yizhi,&Zhang, Huan.(2012).Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty.MOLECULAR MEDICINE REPORTS,5(6),1497-1502.
MLA Ma, Bingbing,et al."Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty".MOLECULAR MEDICINE REPORTS 5.6(2012):1497-1502.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ma, Bingbing]的文章
[Liang, Gangzhu]的文章
[Zhang, Fuxian]的文章
百度学术
百度学术中相似的文章
[Ma, Bingbing]的文章
[Liang, Gangzhu]的文章
[Zhang, Fuxian]的文章
必应学术
必应学术中相似的文章
[Ma, Bingbing]的文章
[Liang, Gangzhu]的文章
[Zhang, Fuxian]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。