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学科主题: 临床医学
题名:
Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty
作者: Ma, Bingbing1; Liang, Gangzhu1; Zhang, Fuxian1; Chen, Yizhi2; Zhang, Huan1
关键词: hydrogen sulfide ; atherosclerosis ; peripheral artery disease ; percutaneous transluminal angioplasty ; smooth muscle cell ; neointimal hyperplasia ; restenosis
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2012-06-01
DOI: 10.3892/mmr.2012.853
卷: 5, 期:6, 页:1497-1502
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Research & Experimental Medicine
关键词[WOS]: CELL-PROLIFERATION ; ATHEROSCLEROSIS ; MODEL ; DISEASE ; H2S
英文摘要:

Peripheral artery disease (PAD) may lead to a poor quality of life. Although percutaneous transluminal angioplasty (PTA) is widely used for the treatment of PAD, restenosis remains a major drawback. Hydrogen sulfide (H,S) plays potential roles in many physiological processes, such as vasodilatation and inhibition of smooth muscle cell proliferation. However, little is known regarding its role in arterial restenosis. In this study, we induced atherosclerotic-like lesions in rabbits, and we treated the rabbits with balloon angioplasty (BA) in a similar manner as PTA performed in the clinic. The rabbits were treated with sodium hydrosulfide (NaHS, a donor of H,S) or DL-propargylglycine (PPG, an inhibitor of H,S synthase). Treatment with NaHS significantly inhibited arterial restenosis following BA by reducing the intimal area and the intima/media ratio, while PPG treatment had a tendency to result in more severe restenosis. NaHS treatment significantly reduced smooth muscle cell (SMC) proliferation and elevated SMC apoptosis in the neointima. In contrast, PPG induced a significant increase in SMC proliferation. In conclusion, H2S attenuates the progression of neointimal hyperplasia and inhibits restenosis after BA. This discovery may lead to potential novel therapies, which can improve the prognosis of PAD patients.

语种: 英语
项目资助者: Capital Medical Development Scientific Research Foundation of China ; Scientific Research Foundation of Peking University Ninth Clinical Hospital, Beijing, China
WOS记录号: WOS:000304182300024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50990
Appears in Collections:北京大学第二临床医学院_血管外科_期刊论文

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作者单位: 1.Peking Univ, Clin Hosp 9, Beijing Shijitan Hosp, Dept Vasc Surg, Beijing 100038, Peoples R China
2.Peking Univ, Clin Hosp 9, Beijing Shijitan Hosp, Dept Pathol, Beijing 100038, Peoples R China

Recommended Citation:
Ma, Bingbing,Liang, Gangzhu,Zhang, Fuxian,et al. Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty[J]. MOLECULAR MEDICINE REPORTS,2012,5(6):1497-1502.
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