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学科主题: 口腔医学
题名:
Improved bioactivity of PAN-based carbon nanofibers decorated with bioglass nanoparticles
作者: Han, Bing1; Zhang, Xuehui2,4; Liu, Haiyang3,4; Deng, Xuliang2; Cai, Qing3; Jia, Xiaolong3; Yang, Xiaoping3; Wei, Yan2; Li, Gang3
关键词: carbon nanofiber ; bioglass ; eletrospinning
刊名: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
发表日期: 2014-03-04
DOI: 10.1080/09205063.2013.861169
卷: 25, 期:4, 页:341-353
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials ; Polymer Science
研究领域[WOS]: Engineering ; Materials Science ; Polymer Science
关键词[WOS]: IN-VITRO ; MECHANICAL-PROPERTIES ; TISSUE REGENERATION ; GLASS ; HYDROXYAPATITE ; MINERALIZATION ; KINETICS ; COATINGS
英文摘要:

Composite nanofibers composed of polyacrylonitrile (PAN)-based carbon nanofibers and bioactive glass (BG) nanoparticles have been prepared by electrospinning and in situ sintering. Morphology observation showed that the BG nanoparticles of size 20-50nm were uniformly distributed on the surface of composite nanofibers with 350nm average diameter after carbonization. Biological mineralization indicated the formation of apatite-like layer on the surface of composite nanofibers, in which the composition of carbonate hydroxyapatite was proved by FTIR and XRD analysis. Cell growth dynamics according to cellular morphology, CCK-8 assay, and alkaline phosphatase activity assay exhibited better cell adhesion, proliferation, and osteogenic induction of bone marrow-derived mesenchymal stem cells cultured on the composite nanofibers, which suggested the higher bioactivity of composite nanofibers compared to pure PAN-based carbon nanofibers.

语种: 英语
所属项目编号: 2012CB933900 ; 2012BAI07B00 ; 2011AA030100 ; Z121100005212007 ; 2011DFA32190 ; YS020212
项目资助者: National Basic Research Program of China ; Key Technologies R&amp ; D Program of China ; National High Technology Research and Development Program of China ; Beijing municipal Science &amp ; Technology Commission Projects ; Key International S&amp ; T Cooperation Projects ; Science Foundation of Peking University School and Hospital of Stomatology
WOS记录号: WOS:000329486600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50991
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Beijing Univ Chem Technol, Minist Educ, Key Lab Carbon Fiber & Funct Polymers, Beijing 100029, Peoples R China
3.Tsinghua Univ, Dept Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China

Recommended Citation:
Han, Bing,Zhang, Xuehui,Liu, Haiyang,et al. Improved bioactivity of PAN-based carbon nanofibers decorated with bioglass nanoparticles[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,2014,25(4):341-353.
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