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学科主题: 临床医学
题名:
Genetic variability in adapter proteins with APPL1/2 is associated with the risk of coronary artery disease in type 2 diabetes mellitus in Chinese Han population
作者: Ma Xiao-wei; Ding Shan; Ma Xiao-dan; Gu Nan; Guo Xiao-hui
关键词: APPL1 ; APPL2 ; genes ; coronary artery disease ; type 2 diabetes mellitus ; Chinese
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-11-20
DOI: 10.3760/cma.j.issn.0366-6999.2011.22.004
卷: 124, 期:22, 页:3618-3621
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PLASMA-PROTEIN ; ADIPONECTIN ; ACTIVATION ; SIGNAL ; AKT
英文摘要:

Background Adaptor proteins containing PH domain, PTB domain, and leucine zipper motif 1 and 2 (APPL1/2) play a key role in cell proliferation in many tissues. APPL1 or APPL2 as an adaptor for adiponectin receptors mediates the signaling pathway of adiponectin which acts as an anti-atherosclerotic adipokine. This study aimed to investigate whether genetic variations in the APPL1/2 genes affect the risk of coronary artery disease (CAD) in Chinese patients with type 2 diabetes mellitus (T2DM).

Methods Seven haplotype-tagging single nucleotide polymorphisms (tag-SNPs) were selected from CHB HapMap database (Phase II) and total 203 CAD-positive cases and 106 CAD-negative controls with T2DM were genotyped for the 7 tag-SNPs by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.

Results The minor allele G of rs4640525 at APPL1 locus was protective from CAD in patients with T2DM, with the carriers of genotype CC at higher risk of CAD compared with non-carriers (OR=2.830, 95% CI 1.285-6.230, P=0.010; OR′=4.992, 95% CI=1.758-14.173, P′=0.003, after adjustment for the other known CAD risk factors); the homozygotes of AA at rs11112412 in APPL2 gene had higher risk of CAD compared with those of GG (adjusted OR′=5.697, 95% CI 1.006-32.257, P′=0.049).

Conclusion Genetic variation(s) in APPL1/2 may be associated with CAD risk in T2DM in Chinese population. Chin Med J 2011;124(22):3618-3621

语种: 英语
所属项目编号: 2006CB503903 ; 2006CB503908
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000297658300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51001
Appears in Collections:北京大学第一临床医学院_内分泌内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China

Recommended Citation:
Ma Xiao-wei,Ding Shan,Ma Xiao-dan,et al. Genetic variability in adapter proteins with APPL1/2 is associated with the risk of coronary artery disease in type 2 diabetes mellitus in Chinese Han population[J]. CHINESE MEDICAL JOURNAL,2011,124(22):3618-3621.
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