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学科主题临床医学
Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols
Liu, Nana1,2,3; Ma, Yanmin4; Li, Rong1,2,3; Jin, Hongyan1,2,3; Li, Min1,2,3; Huang, Xiang1,2,3; Feng, Huai L.1,5; Qiao, Jie1,2,3
关键词Amphiregulin Egf Human Follicular Fluid Gnrh Analog Cos Ivf
刊名ENDOCRINE
2012-12-01
DOI10.1007/s12020-012-9706-z
42期:3页:708-716
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]EPIDERMAL-GROWTH-FACTOR ; IN-VITRO-FERTILIZATION ; CUMULUS-OOCYTE COMPLEXES ; VESICLE-STAGE OOCYTES ; HUMAN GRANULOSA-CELLS ; PREOVULATORY FOLLICLES ; CULTURE-MEDIUM ; FACTOR-ALPHA ; RECEPTOR ; MATURATION
英文摘要

Epidermal growth factor (EGF)-like growth factors, such as amphiregulin (AR) and EGF, have emerged as mediators to propagate Luteinizing hormone (LH) stimulus for the oocyte maturation throughout the preovulatory follicle, because cumulus cells and oocytes express few or no LH receptors. This study was to compare AR and EGF concentrations in follicular fluid (FF) among four controlled ovary stimulation (COS) protocols and to investigate the relationship between FF EGF-like growth factors and COS outcomes. Ninety-five patients who underwent in vitro fertilization-embryo transfer (IVF-ET) were treated by four different COS protocols, including gonadotropin-releasing hormone agonist (GnRH-a) long protocol, GnRH-a ultra-long protocol, GnRH-a short protocol, and GnRH antagonist protocol. FF was taken on oocyte retrieval day. FF AR and EGF concentrations were measured and their correlations with COS outcomes were analyzed. FF AR concentration was significantly different from each other among four COS protocol groups (GnRH-a ultra-long protocol group, 186.12 ng/ml; GnRH-a long protocol group, 128.35 ng/ml; GnRH antagonist protocol group, 108.23 ng/ml; GnRH-a short protocol group, 77.13 ng/ml, p < 0.05). FF AR concentrations were higher in GnRH-a ultra-long and long protocol groups, while number of oocytes retrieval, available embryos, and good quality embryos in these two groups were also significantly higher than GnRH-a short protocol group and GnRH antagonist protocol group. FF AR concentration was positively correlated with available embryos, but negatively correlated with serum LH level on hCG day. FF EGF concentration had no relationship with COS parameters. Different COS protocols might have variable effects on AR synthesis. FF AR might be a good indicator to predict the number of oocytes and embryos. FF AR elevation may result in increasing the number of oocyte retrieval and embryo generation, consequently increased cumulative pregnancy rate.

语种英语
WOS记录号WOS:000312073500036
项目编号30825038 ; 81170538
资助机构National Natural Science Foundation for Distinguished Young Scholar ; National Natural Science Foundation of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51002
专题北京大学第三临床医学院_生殖医学中心
北京大学第三临床医学院_妇产科
作者单位1.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
4.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Reprod Med Ctr, Beijing 100026, Peoples R China
5.Cornell Univ, Weill Med Coll, New York Hosp Queens, Dept Obstet & Gynecol, New York, NY 11355 USA
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GB/T 7714
Liu, Nana,Ma, Yanmin,Li, Rong,et al. Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols[J]. ENDOCRINE,2012,42(3):708-716.
APA Liu, Nana.,Ma, Yanmin.,Li, Rong.,Jin, Hongyan.,Li, Min.,...&Qiao, Jie.(2012).Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols.ENDOCRINE,42(3),708-716.
MLA Liu, Nana,et al."Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols".ENDOCRINE 42.3(2012):708-716.
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