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学科主题: 临床医学
题名:
Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols
作者: Liu, Nana1,2,3; Ma, Yanmin4; Li, Rong1,2,3; Jin, Hongyan1,2,3; Li, Min1,2,3; Huang, Xiang1,2,3; Feng, Huai L.1,5; Qiao, Jie1,2,3
关键词: Amphiregulin ; EGF ; Human follicular fluid ; GnRH analog ; COS ; IVF
刊名: ENDOCRINE
发表日期: 2012-12-01
DOI: 10.1007/s12020-012-9706-z
卷: 42, 期:3, 页:708-716
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: EPIDERMAL-GROWTH-FACTOR ; IN-VITRO-FERTILIZATION ; CUMULUS-OOCYTE COMPLEXES ; VESICLE-STAGE OOCYTES ; HUMAN GRANULOSA-CELLS ; PREOVULATORY FOLLICLES ; CULTURE-MEDIUM ; FACTOR-ALPHA ; RECEPTOR ; MATURATION
英文摘要:

Epidermal growth factor (EGF)-like growth factors, such as amphiregulin (AR) and EGF, have emerged as mediators to propagate Luteinizing hormone (LH) stimulus for the oocyte maturation throughout the preovulatory follicle, because cumulus cells and oocytes express few or no LH receptors. This study was to compare AR and EGF concentrations in follicular fluid (FF) among four controlled ovary stimulation (COS) protocols and to investigate the relationship between FF EGF-like growth factors and COS outcomes. Ninety-five patients who underwent in vitro fertilization-embryo transfer (IVF-ET) were treated by four different COS protocols, including gonadotropin-releasing hormone agonist (GnRH-a) long protocol, GnRH-a ultra-long protocol, GnRH-a short protocol, and GnRH antagonist protocol. FF was taken on oocyte retrieval day. FF AR and EGF concentrations were measured and their correlations with COS outcomes were analyzed. FF AR concentration was significantly different from each other among four COS protocol groups (GnRH-a ultra-long protocol group, 186.12 ng/ml; GnRH-a long protocol group, 128.35 ng/ml; GnRH antagonist protocol group, 108.23 ng/ml; GnRH-a short protocol group, 77.13 ng/ml, p < 0.05). FF AR concentrations were higher in GnRH-a ultra-long and long protocol groups, while number of oocytes retrieval, available embryos, and good quality embryos in these two groups were also significantly higher than GnRH-a short protocol group and GnRH antagonist protocol group. FF AR concentration was positively correlated with available embryos, but negatively correlated with serum LH level on hCG day. FF EGF concentration had no relationship with COS parameters. Different COS protocols might have variable effects on AR synthesis. FF AR might be a good indicator to predict the number of oocytes and embryos. FF AR elevation may result in increasing the number of oocyte retrieval and embryo generation, consequently increased cumulative pregnancy rate.

语种: 英语
所属项目编号: 30825038 ; 81170538
项目资助者: National Natural Science Foundation for Distinguished Young Scholar ; National Natural Science Foundation of China
WOS记录号: WOS:000312073500036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51002
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China
4.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Reprod Med Ctr, Beijing 100026, Peoples R China
5.Cornell Univ, Weill Med Coll, New York Hosp Queens, Dept Obstet & Gynecol, New York, NY 11355 USA

Recommended Citation:
Liu, Nana,Ma, Yanmin,Li, Rong,et al. Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols[J]. ENDOCRINE,2012,42(3):708-716.
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